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Synthesis, DNA binding, antioxidant and cytotoxic activities of ruthenium(II) complexes of a Schiff base ligand

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Abstract

Three ruthenium(II) complexes, [Ru(CO)Cl(PPh3)L], [Ru(CO)Cl(AsPh3)L] and [Ru(CO)Cl(Py)L], were synthesized from the reactions of 2-(benzothiazol-2-yliminomethyl)-phenol (HL) with [RuHCl(CO)B(EPh3)2], where B = PPh3, AsPh3 or pyridine, and E = P or As. All the complexes have been characterized by physicochemical and spectroscopic methods. The structure of the free ligand HL was determined by single crystal X-ray diffraction. The binding of the free ligand and its complexes with CT-DNA was studied using electronic absorption spectroscopy. In addition, the free ligand and its complexes were subjected to antioxidant activity tests, which showed that they all possess significant scavenging effects against DPPH and OH radicals. The in vitro cytotoxicities of the compounds were assessed using tumor (HeLa and MCF-7) cell lines.

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Acknowledgments

We sincerely thank University Grants Commission (UGC), New Delhi, for financial support [MRP Scheme. No. 38-222/2009 (SR)].

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Authors and Affiliations

  1. Post Graduate and Research Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore, 641 020, Tamil Nadu, India

    Subbaiyan Sathiyaraj, Krishnan Sampath & Chinnasamy Jayabalakrishnan

  2. Department of Chemistry, Howard University, Washington, DC, 20059, USA

    Ray J. Butcher

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  1. Subbaiyan Sathiyaraj
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  2. Krishnan Sampath
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  3. Ray J. Butcher
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  4. Chinnasamy Jayabalakrishnan
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Correspondence to Chinnasamy Jayabalakrishnan.

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Sathiyaraj, S., Sampath, K., Butcher, R.J. et al. Synthesis, DNA binding, antioxidant and cytotoxic activities of ruthenium(II) complexes of a Schiff base ligand. Transition Met Chem 38, 291–298 (2013). https://doi.org/10.1007/s11243-013-9690-z

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