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Genetic thromobophilia in pregnancy: a case–control study among North Indian women

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Abstract

In the present study, an attempt is made to understand the role of genetic thrombophilias i.e. MTHFR C677T and FVL in the causation of various pregnancy complications like pregnancy induced hypertension (PIH), recurrent abortions, intra-uterine growth retardation (IUGR) and intra-uterine death on the whole and also individually along with the comparative assessment of pathophysiological basis of various pregnancy complications via the genetic proximities. One thousand and eleven (1,011) women of reproductive age group were recruited in the present study comprising various complications and controls. Recruitment criteria for all the pregnancy complications and controls was made and followed strictly. MTHFR C677T and FVL mutation detection was done in all the subjects. Vegetarianism was found to be significant risk factors for all the pregnancy complications and also when assessed individually. With respect to MTHFR C677T polymorphism, higher frequency of 677T allele was found among controls as compared to cases. 677T allele was found to pose decreased risk for various pregnancy complications on the whole and also individually. On adjusting the diet, regression analysis revealed no risk of mutant allele (T) for various pregnancy complications. FVL homozygous mutants were found to be absent among controls. In conclusion, the present study depicts dietary pattern as one of the most important factors in demonstrating the role of MTHFR C677T in various pregnancy complications and is indicative of a relatively deleterious effect of double dose of FVL in the presently studied population. Additionally, these polymorphisms play an important role in the orchestration of PIH to IUGR and vice versa.

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Acknowledgments

We thank Department of Biotechnology, Government of India, India for funding the present study. We also thank all the subjects recruited in the present study.

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Authors and Affiliations

  1. Department of Anthropology, University of Delhi, Delhi, India

    Lovejeet Kaur, Shweta Kaushik, Mohinder Pal Sachdeva & Kallur Nava Saraswathy

  2. Department of Obstetrics and Gynecology, Lady Hardinge Medical College, Delhi, India

    Manju Puri & Shubha Sagar Trivedi

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  1. Lovejeet Kaur
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  2. Manju Puri
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  3. Shweta Kaushik
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  4. Mohinder Pal Sachdeva
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  5. Shubha Sagar Trivedi
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  6. Kallur Nava Saraswathy
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Correspondence to Kallur Nava Saraswathy.

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Kaur, L., Puri, M., Kaushik, S. et al. Genetic thromobophilia in pregnancy: a case–control study among North Indian women. J Thromb Thrombolysis 35, 250–256 (2013). https://doi.org/10.1007/s11239-012-0797-4

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