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Modulation of Antioxidant Enzyme Expression by PTU-Induced Hypothyroidism in Cerebral Cortex of Postnatal Rat Brain

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Abstract

This study aimed to elucidate the effect of 6-n-propylthiouracil (PTU)-induced hypothyroidism on oxidative stress parameters and expression of antioxidant enzymes in cerebral cortex of rat brain during postnatal development. A significant decrease in levels of lipid peroxidation and H2O2 were seen in 7 and 30 days old PTU-treated rats with respect to their controls. Significantly decreased activities of superoxide dismutase (SOD) and catalase (CAT) along with the translated products of SOD1 and SOD2 were observed in 7, 15 and 30 days old PTU-treated rats as compared to their respective controls. However, increase in translated product of CAT was seen in all age groups of PTU-treated rats. Glutathione peroxidase activity was decreased in 7 days and increased in 15 days old PTU-treated rats with respect to their control groups. Histological sections clearly show a decline in neuronal migration with neurons packed together in the hypothyroid group as compared to the control.

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Acknowledgments

Shravani Bhanja and Srikanta Jena are very thankful to the DST and DBT, Government of India, respectively for their financial grants (DST grant No. SL/WOS-A/LS-179/2005 and DBT Ref. No. -JRF/05-06/123). Authors are also extremely grateful to Prof. G.B.N. Chainy, Head (former), Department of Biotechnology, Utkal University, Bhubaneswar, Odisha, India, for extending laboratory facilities and mentoring the authors throughout the tenure of the work.

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  1. Krishnamacharya Healing and Yoga Foundation, Chennai, 600028, India

    Shravani Bhanja

  2. Department of Biotechnology, Utkal University, Bhubaneswar, 751004, Odisha, India

    Srikanta Jena

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  1. Shravani Bhanja
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  2. Srikanta Jena
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Correspondence to Srikanta Jena.

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Bhanja, S., Jena, S. Modulation of Antioxidant Enzyme Expression by PTU-Induced Hypothyroidism in Cerebral Cortex of Postnatal Rat Brain. Neurochem Res 38, 42–49 (2013). https://doi.org/10.1007/s11064-012-0885-z

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  • DOI: https://doi.org/10.1007/s11064-012-0885-z

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