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Characterization and in vivo evaluation of a bio-corrodible nitrided iron stent

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Abstract

A bio-corrodible nitrided iron stent was developed using a vacuum plasma nitriding technique. In the nitrided iron stents, the tensile strength, radial strength, stiffness and in vitro electrochemical corrosion rate were significantly increased compared with those of the control pure iron stent. To evaluate its performance in vivo, the deployment of the nitrided iron stents in juvenile pig iliac arteries was performed. At 3 or 6 months postoperatively, the stented vessels remained patent well; however, slight luminal loss resulting from intimal hyperplasia and relative stenosis of the stented vessel segment with piglets growth were observed by 12 months; no thrombosis or local tissue necrosis was found. At 1 month postoperatively, a nearly intact layer of endothelial cells formed on the stented vessel wall. Additionally, a decreased inflammation scoring, considerably corroded struts and corrosion products accumulation were seen. These findings indicate the potential of this nitrided iron stent as an attractive biodegradable stent.

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Acknowledgments

This program was financially supported by the National 863 Program (Grant No. 2011AA030103), the Provincial Science and Technology Plan Program of Guangdong (Grant No. 2008A030102006), the Municipal Key Technologies R&D Program of Shenzhen (Grant No. ZD200904300071A), the Municipal Special Funds for Industry-University-Research Institute Collaboration (Grant No. SY200806270124A), the Municipal Science and Technology Plan of Shenzhen General Program (Grant No. JSA201006010138A), and the Municipal Education committee of Shanghai-Project in Budget (Grant No. 2011JW54). The authors thank Ke Dai, Ning Ma, Ruidong Zhang, Zuming Jiang, Xiaoqing Yu, and Yiwei Chen from the Heart Center, Shanghai Children’s Medical Center, Shanghai JiaoTong University School of Medicine, China, for their assistance with the animal experiments.

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Authors and Affiliations

  1. Department of Cardiology, Shanghai Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, China

    Qimao Feng

  2. R&D Center, Lifetech Scientific (Shenzhen) Co Ltd, Shenzhen, 518057, China

    Deyuan Zhang, Chaohua Xin, Xiangdong Liu, Wenjiao Lin & Wanqian Zhang

  3. Children’s Heart Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China

    Sun Chen & Kun Sun

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  1. Qimao Feng
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Correspondence to Kun Sun.

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Feng, Q., Zhang, D., Xin, C. et al. Characterization and in vivo evaluation of a bio-corrodible nitrided iron stent. J Mater Sci: Mater Med 24, 713–724 (2013). https://doi.org/10.1007/s10856-012-4823-z

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  • DOI: https://doi.org/10.1007/s10856-012-4823-z

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