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Glycosaminoglycanomics: where we are

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Abstract

Glycosaminoglycans regulate numerous physiopathological processes such as development, angiogenesis, innate immunity, cancer and neurodegenerative diseases. Cell surface GAGs are involved in cell-cell and cell-matrix interactions, cell adhesion and signaling, and host-pathogen interactions. GAGs contribute to the assembly of the extracellular matrix and heparan sulfate chains are able to sequester growth factors in the ECM. Their biological activities are regulated by their interactions with proteins. The structural heterogeneity of GAGs, mostly due to chemical modifications occurring during and after their synthesis, makes the development of analytical techniques for their profiling in cells, tissues, and biological fluids, and of computational tools for mining GAG-protein interaction data very challenging. We give here an overview of the experimental approaches used in glycosaminoglycomics, of the major GAG-protein interactomes characterized so far, and of the computational tools and databases available to analyze and store GAG structures and interactions.

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Acknowledgments

The creation and maintenance of MatrixDB database mentioned in this review was supported in part by the European Commission to SRB (PSIMEx grant FP7-HEALTH-2007-223411), and by the grant n° DBI20141231336 awarded to SRB by the “Fondation pour la Recherche Médicale”.

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  1. Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, UMR 5246 CNRS - Université Lyon 1, INSA Lyon, CPE Lyon, 69622, Villeurbanne Cedex, France

    Sylvie Ricard-Blum

  2. SIB Swiss Institute of Bioinformatics, 1 Rue Michel-Servet, 1211, Geneva, Switzerland

    Frédérique Lisacek

  3. Computer Science Department, University of Geneva, Geneva, Switzerland

    Frédérique Lisacek

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  1. Sylvie Ricard-Blum
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Ricard-Blum, S., Lisacek, F. Glycosaminoglycanomics: where we are. Glycoconj J 34, 339–349 (2017). https://doi.org/10.1007/s10719-016-9747-2

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