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Donor derived malignancy following transplantation: a review

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Abstract

Organ and tissue transplant is now the treatment of choice for many end stage diseases. In the recent years, there has been an increasing demand for organs but not a similar increase in the supply leading to a severe shortage of organs for transplant resulted in increasing wait times for recipients. This has resulted in expanded donor criteria to include older donors and donors with mild disease. In spite of implementation of more stringent criteria for donor selection, there continues to be some risk of donor derived malignancy. Malignancy after transplantation can occur in three different ways: (a) de-novo occurrence, (b) recurrence of malignancy, and (c) donor-related malignancy. Donor related malignancy can be either due to direct transmission of tumor or due to tumor arising in cells of donor origin. We will review donor related malignancies following solid organ transplantation and hematopoeitic progenitor cell transplantation. Further, we will briefly review the methods for detection and management of these donor related malignancies.

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Abbreviations

AML:

Acute myeloid leukemia

B-HCG:

B-human choroinic gonadotrophin

CIS:

Carcinoma in situ

CML:

Chronic myeloid leukemia

CMV:

Cytomegalovirus

CNS:

Central nervous system

CTTR:

Cincinnati Transplant Tumor Registry

EBV:

Epstein Barr Virus

FISH:

Fluorescent in situ hybridization

HBV:

Hepatitis B virus

HCV:

Hepatitis C virus

HHV-8:

Human herpes virus 8

HPCT:

Hematopoeitic progenitor cell transplantation

HPV:

Human papilloma virus

HTLV:

Human T-lymphotropic virus

IPTTR:

Israel Penn Transplant Tumor Registry

MDS:

Myelodysplastic syndrome

NHL:

Non-Hodgkin’s lymphoma

OPTN:

Organ Procurement and Transplantation Network

PTLD:

Post-transplant lymphoproliferative disorder

RFLP:

Restriction fragment length polymorphism

SNP:

Single nucleotide polymorphism

STR:

Repetitive sequence of 2–7 nucleotides long

UNOS:

United Network of Organ Sharing

VNTR:

Repetitive sequence of 9–45 nucleotides long

WHO:

World Health Organization

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  1. Department of Pathology and Immunology, Washington University, 660 S Euclid Ave #8118, St Louis, MO, 63110, USA

    Manish J. Gandhi

  2. Puget Sound Blood Center, Seattle, WA, USA

    D. Michael Strong

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Gandhi, M.J., Strong, D.M. Donor derived malignancy following transplantation: a review. Cell Tissue Banking 8, 267–286 (2007). https://doi.org/10.1007/s10561-007-9036-1

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