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Neuropsychological studies in breast cancer: in search of chemobrain

  • Invited Commentary
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Breast Cancer Research and Treatment Aims and scope Submit manuscript

The Original Article was published on 16 July 2008

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References

  1. Ahles TA, Saykin AJ (2007) Candidate mechanisms for chemotherapy-induced cognitive changes. Nat Rev Cancer 7:192–201. doi:10.1038/nrc2073

    Article  PubMed  CAS  Google Scholar 

  2. Vardy J, Wefel JS, Ahles T, Tannock IF, Schagen SB (2008) Cancer and cancer-therapy related cognitive dysfunction: an international perspective from the Venice cognitive workshop. Ann Oncol 19:623–629. doi:10.1093/annonc/mdm500

    Article  PubMed  CAS  Google Scholar 

  3. Tannock IF, Ahles TA, Ganz PA, van Dam FS (2004) Cognitive impairment associated with chemotherapy for cancer: report of a workshop. J Clin Oncol 22:2233–2239. doi:10.1200/JCO.2004.08.094

    Article  PubMed  Google Scholar 

  4. Quesnel C, Savard J, Ivers H (2008) Cognitive impairments associated with breast cancer treatments: results from a longitudinal study. Breast Cancer Res Treat. doi:10.1007/s10549-008-0114-2

    PubMed  Google Scholar 

  5. Hermelink K, Untch M, Lux MP et al (2007) Cognitive function during neoadjuvant chemotherapy for breast cancer: results of a prospective, multicenter, longitudinal study. Cancer 109:1905–1913. doi:10.1002/cncr.22610

    Article  PubMed  CAS  Google Scholar 

  6. Schagen SB, Muller MJ, Boogerd W, Mellenbergh GJ, van Dam FS (2006) Change in cognitive function after chemotherapy: a prospective longitudinal study in breast cancer patients. J Natl Cancer Inst 98:1742–1745

    Article  PubMed  CAS  Google Scholar 

  7. Schagen SB, Vardy J (2007) Cognitive dysfunction in people with cancer. Lancet Oncol 8:852–853. doi:10.1016/S1470-2045(07)70287-5

    Article  PubMed  Google Scholar 

  8. Jenkins V, Shilling V, Deutsch G et al (2006) A 3 year prospective study of the effects of adjuvant treatments on cognition in women with early stage breast cancer. Br J Cancer 94:828–834. doi:10.1038/sj.bjc.6603029

    Article  PubMed  CAS  Google Scholar 

  9. Singer JD, Willett JB (2003) Applied longitudinal data analysis: modeling change and event occurrence. Oxford University Press, New York

    Google Scholar 

  10. Chelune CJ, Naugle RI, Lueders H, Sedlak J, Awad IIA (1993) Individual change after epilepsy surgery: practice effects and base-rate information. Neuropsychology 7:41–52. doi:10.1037/0894-4105.7.1.41

    Article  Google Scholar 

  11. Heaton RK, Temkin N, Dikmen S et al (2001) Detecting change: a comparison of three neuropsychological methods, using normal and clinical samples. Arch Clin Neuropsychol 16:75–91. doi:10.1016/S0887-6177(99)00062-1

    PubMed  CAS  Google Scholar 

  12. Sherwin BB (2003) Estrogen and cognitive functioning in women. Endocr Rev 24:133–151. doi:10.1210/er.2001-0016

    Article  PubMed  CAS  Google Scholar 

  13. Jenkins V, Shilling V, Fallowfield L, Howell A, Hutton S (2004) Does hormone therapy for the treatment of breast cancer have a detrimental effect on memory and cognition? A pilot study. Psychooncology 13:61–66. doi:10.1002/pon.709

    Article  PubMed  Google Scholar 

  14. Castellon SA, Ganz PA, Bower JE, Petersen LA, Abraham L, Greendale GA (2004) Neurocognitive performance in breast cancer survivors exposed to adjuvant chemotherapy and tamoxifen. J Clin Exp Neuropsychol 26:955–969. doi:10.1080/13803390490510905

    Article  PubMed  Google Scholar 

  15. Silverman DH, Dy CJ, Castellon SA et al (2007) Altered frontocortical, cerebellar, and basal ganglia activity in adjuvant-treated breast cancer survivors 5–10 years after chemotherapy. Breast Cancer Res Treat 103:303–311. doi:10.1007/s10549-006-9380-z

    Article  PubMed  CAS  Google Scholar 

  16. Saykin AJ, Wishart HA, Rabin LA et al (2006) Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology 67:834–842. doi:10.1212/01.wnl.0000234032.77541.a2

    Article  PubMed  CAS  Google Scholar 

  17. Sherwin BB, Henry JF (2008) Brain aging modulates the neuroprotective effects of estrogen on selective aspects of cognition in women: a critical review. Front Neuroendocrinol 29:88–113

    PubMed  CAS  Google Scholar 

  18. Ferguson RJ, Ahles TA, Saykin AJ et al (2007) Cognitive-behavioral management of chemotherapy-related cognitive change. Psychooncology 16:772–777. doi:10.1002/pon.1133

    Article  PubMed  Google Scholar 

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Acknowledgment

Supported in part by the Breast Cancer Research Foundation.

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Correspondence to Patricia A. Ganz.

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This is an invited commentary to doi:10.1007/s10549-005-9114-7.

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Castellon, S., Ganz, P.A. Neuropsychological studies in breast cancer: in search of chemobrain. Breast Cancer Res Treat 116, 125–127 (2009). https://doi.org/10.1007/s10549-008-0211-2

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  • DOI: https://doi.org/10.1007/s10549-008-0211-2

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