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Retinal endothelial cell apoptosis

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Abstract

Retinal endothelial cell (REC) apoptosis occurs in response to a number of stressors, including high glucose, oxidative stress, hypoxia. Because these stressors are common factors in a number of ocular diseases, it is critical to understand the cellular mechanisms by which apoptosis occurs in REC. This review discusses the various models of REC used in ophthalmological research. The mechanisms responsible for REC apoptosis are discussed, as well as potential therapeutics currently under development to prevent REC apoptosis. The primary goal of this review is provide the reader with a background knowledge of the current state of research ongoing in REC apoptosis and potential avenues for future testing.

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Acknowledgments

Supported by National Eye Institute Vision Grant R01EY022045 (JJS); Juvenile Diabetes Research Foundation Grant (2-2011-597 to JJS); Oxnard Foundation (JJS); Research to Prevent Blindness Award (PI:Barrett Haik); and NEI Vision Core Grant: PHS 3P30 EY013080 (PI: Dianna Johnson).

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Authors and Affiliations

  1. Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, 930 Madison Avenue, Suite 768A, Memphis, TN, 38163, USA

    Jena J. Steinle

  2. Department of Anatomy & Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA

    Jena J. Steinle

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  1. Jena J. Steinle
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Correspondence to Jena J. Steinle.

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Steinle, J.J. Retinal endothelial cell apoptosis. Apoptosis 17, 1258–1260 (2012). https://doi.org/10.1007/s10495-012-0777-3

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