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Fast and efficient synthesis of N-substituted β-aminobutyric acids by grinding at room temperature

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Abstract

Green chemistry is gaining increasing interest due to the growing awareness of the chemical community for sustainable development. Green chemistry solutions include synthesis without solvent and catalyst because many solvents and catalysts are toxic and expensive. Herein, we report the solvent and catalyst free method for the synthesis of N-substituted derivatives of β-aminobutyric acid by direct aza-Michael addition of amines to crotonic acid. The protocol involves simple mixing or grinding the reactants at room temperature. The β-amino acid derivatives were obtained in 82–100 % yield with a short reaction time without any tedious workup procedures. Our findings thus reveal a promising alternative to previously used procedures.

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Article Open access 02 December 2021

Baoxin Zhang, Dilver Peña Fuentes & Armin Börner

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Acknowledgments

The authors acknowledge The Director and The HOD (Department of Chemistry), NITK Surathkal for providing the research infrastructure. SIB is thankful to NITK for research fellowship. We are also grateful to CSMCRI Bhavnagar, SAIF Panjab University, and IISc Bangalore for spectral analysis.

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Authors and Affiliations

  1. Supramolecular Chemistry Laboratory, Department of Chemistry, National Institute of Technology Karnataka (NITK), Srinivasnagar, Surathkal, Mangalore, 575025, Karnataka, India

    Subrahmanya Ishwar Bhat & Darshak R. Trivedi

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  1. Subrahmanya Ishwar Bhat
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  2. Darshak R. Trivedi
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Correspondence to Darshak R. Trivedi.

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Bhat, S.I., Trivedi, D.R. Fast and efficient synthesis of N-substituted β-aminobutyric acids by grinding at room temperature. Environ Chem Lett 11, 91–97 (2013). https://doi.org/10.1007/s10311-013-0400-z

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  • DOI: https://doi.org/10.1007/s10311-013-0400-z

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