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A histological evaluation of a low-level laser therapy as an adjunct to periodontal therapy in patients with diabetes mellitus

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Abstract

Diabetes mellitus (DM) and chronic periodontitis are common chronic diseases in adults in the world population. DM has a strong influence on the oral cavity and represents a risk factor for gingivitis and periodontitis. Low-level laser therapy (LLLT) has proven effective in the reduction of inflammation and swelling. The aim of the present study was to evaluate the efficacy of LLLT in diabetic periodontitis through histological analysis. A total of 300 diabetics with chronic periodontal disease and teeth indicated for extraction were assigned into six equal groups. In the groups 1 and 4, indicated teeth were extracted before treatment, and in the rest of the groups upon completion of the entire treatment. All patients received oral hygiene instructions and full-mouth conservative periodontal treatment. In groups 3 and 6, LLLT was applied (670 nm, 5 mW, 2 J/cm2, 16 min, 5 days). Histologic findings of gingival tissue treated with LLLT showed expressed healing, as is evident by the absence of inflammatory cells. Tissue edema could not be seen, and the number of blood vessels was reduced. In the gingival lamina, propria pronounced collagenization and homogenization were present. It can be concluded that LLLT has shown efficacy in the treatment of periodontitis in diabetics. Because of more pronounced alterations of periodontium in diabetics, the use of LLLT is of particular importance.

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Acknowledgments

This research was supported by a grant from the Serbian Ministry of Education and Science, No.175061.

Author disclosure statement

No competing financial interests exist.

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Authors and Affiliations

  1. Department of Periodontology and Oral Medicine, Faculty of Medicine, University of Niš, 45/19 Nikola Tesla Blvd, 18000, Niš, Serbia

    Radmila Obradović & Ljiljana Kesić

  2. Institute of Pathology, Faculty of Medicine, University of Niš, Niš, Serbia

    Dragan Mihailović

  3. Clinic for Endocrinology, Faculty of Medicine, University of Nis, Niš, Serbia

    Slobodan Antić

  4. Department of Oral Surgery, Faculty of Medicine, University of Nis, Niš, Serbia

    Goran Jovanović

  5. Institute of Histology, Faculty of Medicine, University of Niš, Niš, Serbia

    Aleksandar Petrović

  6. Department of Periodontology, Faculty of Dentistry, University “St. Cyril and Methodius”, Skopje, Macedonia

    Snežana Peševska

Authors
  1. Radmila Obradović
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  2. Ljiljana Kesić
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  3. Dragan Mihailović
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  4. Slobodan Antić
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  5. Goran Jovanović
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  6. Aleksandar Petrović
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  7. Snežana Peševska
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Correspondence to Radmila Obradović.

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Obradović, R., Kesić, L., Mihailović, D. et al. A histological evaluation of a low-level laser therapy as an adjunct to periodontal therapy in patients with diabetes mellitus. Lasers Med Sci 28, 19–24 (2013). https://doi.org/10.1007/s10103-012-1058-7

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  • DOI: https://doi.org/10.1007/s10103-012-1058-7

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