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A high-efficiency three-dimensional helical micromixer in fused silica

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Abstract

True three-dimensional (3D) micromixers in fused silica are highly desirable for efficient and compact mixing in microfluidic applications. However, realization of such devices remains technically challenging. Here, we report high-quality fabrication of 3D helical microchannels in fused silica by taking the full advantage of an improved femtosecond laser irradiation followed by chemical etching process, and a glass-PDMS interface structure is introduced for assembling 3D helical micromixer. Highly efficient mixing is achieved in the helical micromixer at low Reynolds numbers, whose excellent mixing performance is approved by the experimental evaluation and computational fluid dynamics simulation.

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References

  • Blazej RG, Kumaresan P, Mathies RA (2006) Microfabricated bioprocessor for integrated nanoliter-scale Sanger DNA sequencing. PNAS 103:7240–7245

    Article  Google Scholar 

  • Chin CD, Laksanasopin T, Cheung YK, Steinmiller D, Linder V, Parsa H, Wang J, Moore H, Rouse R, Umviligihozo G, Karita E, Mwambarangwe L, Braunstein SL, Wijgert JVD, Sahabo R, Justman JE, Sadr WE, Sia SK (2011) Microfluidics-based diagnostics of infectious diseases in the developing world. Nat Med 17:1015–1019

    Article  Google Scholar 

  • Dean WR, Hurst JM (1927) Note on the motion of fluid in a curved pipe. Phil Mag 4:208–223

    MATH  Google Scholar 

  • Dean WR, Hurst JM (1928) The stream-line motion of fluid in a curved pipe. Phil Mag 5:673–695

    Google Scholar 

  • Jang B, Funakoshi M (2009) Chaotic mixing in a helix-like pipe with periodic variations in curvature and torsion. Fluid Dyn Res 42: 035506

    Google Scholar 

  • Jani JM, Wessling M, Lammertink RGH (2011) Geometrical influence on mixing in helical porous membrane microcontactors. J Membr Sci 378:351–358

    Article  Google Scholar 

  • Kim DS, Lee SH, Kwon TH, Ahn CH (2005) A serpentine laminating micromixer combining splitting/recombination and advection. Lab Chip 5:739–747

    Article  Google Scholar 

  • Li Y, Qu SL, Guo ZY (2011) Fabrication of microfluidic devices in silica glass by water-assisted ablation with femtosecond laser pulses. J Micromech Microeng 21:075008

    Google Scholar 

  • Liao Y, Song J, Li E, Luo Y, Shen Y, Chen D, Cheng Y, Xu ZZ, Sugiokad K, Midorikawa K (2012) Rapid prototyping of three-dimensional microfluidic mixers in glass by femtosecond laser direct writing. Lab Chip 12:746–749

    Article  Google Scholar 

  • Liu RH, Stremler MA, Sharp KV, Olsen MG, Santiago JG, Adrian RJ, Aref H, Beebe DJ (2000) Passive mixing in a three-dimensional serpentine microchannel. J Microelectromech S 9:190–197

    Article  Google Scholar 

  • Liu HW, Chen F, Yang Q, Si JH, Hou X (2010) Investigation on femtosecond laser-assisted microfabrication in silica glasses. In: Proceedings of SPIE-The International Society for Optical Engineering 7843. doi:10.1117/12.869845

  • Mansur EA, Ye MX, Wang YD, Dai YY (2008) A state-of-the-art review of mixing in microfluidic mixers. Chin J Chem Eng 16:503–516

    Article  Google Scholar 

  • Manz A, Graber N, Widmer HM (2011) Miniaturized total chemical analysis systems: a novel concept for chemical sensing. Sens Actuat B Chem 1:244–248

    Article  Google Scholar 

  • Marcinkevicius A, Juodkazis S, Watanabe M, Miwa M, Matsuo S, Misawa H, Nishii J (2001) Femtosecond laser-assisted three-dimensional microfabrication in silica. Opt Lett 26:277–279

    Article  Google Scholar 

  • Sasmito P, Kurnia JC, Mujumdar AS (2012) Numerical evaluation of transport phenomena in a T-junction microreactor with coils of different configurations. Ind Eng Chem Res 51:1970–1980

    Article  Google Scholar 

  • Sayah A, Thivolle PA, Parashar VK, Gijs MAM (2010) Three-dimensional mixers with non-planar microchannels in a monolithic glass substrate using oblique powder blasting. J Micromech Microeng 20:085028

    Google Scholar 

  • Schulze P, Ludwig M, Kohler F, Belder D (2005) Deep UV laser-induced fluorescence detection of unlabeled drugs and proteins in microchip electrophoresis. Anal Chem 77:1325–1329

    Article  Google Scholar 

  • Therriault D, White SR, Lewis JA (2003) Chaotic mixing in three-dimensional microvascular networks fabricated by direct-write assembly. Nat Mater 2:265–374

    Article  Google Scholar 

  • Ujiie T, Kikuchi T, Ichiki T, Horiike Y (2000) Fabrication of quartz microcapillary electrophoresis chips using plasma etching. Jpn J Appl Phys 39:3677–3682

    Article  Google Scholar 

  • Verma MKS, Ganneboyina SR, Vinayak RR, Ghatak A (2008) Three-dimensional multihelical microfluidic mixers for rapid mixing of liquids. Langmuir 24:2248–2251

    Article  Google Scholar 

  • Vijayendran RA, Motsegood KM, Beebe DJ, Leckband DE (2003) Evaluation of a three-dimensional micromixer in a surface-based biosensor. Langmuir 19:1824–1828

    Article  Google Scholar 

  • Yasui T, Omoto Y, Osato K, Kaji N, Suzuki N, Naito T, Watanabe M, Okamoto Y, Tokeshi M, Shamoto E, Baba Y (2011) Microfluidic baker’s transformation device for three-dimensional rapid mixing. Lab Chip 11:3356–3360

    Article  Google Scholar 

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Acknowledgments

This work is supported by the National Science Foundation of China under the Grant Nos. 61176113, the Program for Changjiang Scholars and Innovative Research Team in University (IRT1033) and the Fundamental Research Funds for the Central Universities of China.

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Correspondence to Feng Chen.

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Liu, K., Yang, Q., He, S. et al. A high-efficiency three-dimensional helical micromixer in fused silica. Microsyst Technol 19, 1033–1040 (2013). https://doi.org/10.1007/s00542-012-1695-6

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  • DOI: https://doi.org/10.1007/s00542-012-1695-6

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