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Expression patterns of nm23 genes during mouse organogenesis

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Abstract

Nucleoside di-phosphate kinase enzyme (NDPK) isoforms, encoded by the nm23 family of genes, may be involved in various cellular differentiation and proliferation processes. We have therefore analyzed the expression of nm23-M1, -M2, -M3, and -M4 during embryonic mouse development. In situ hybridization data has revealed the differential expression of nm23 mRNA during organogenesis. Whereas nm23-M1 and -M3 are preferentially expressed in the nervous and sensory systems, nm23-M2 mRNA is found ubiquitously. Irrespective of the developmental state studied, nm23-M4 mRNA is only expressed at low levels in a few embryonic organs. In the cerebellum and cerebral cortex, nm23-M1, -M2, and -M3 are present in the neuronal differentiation layer, whereas nm23-M4 mRNA is distributed in the proliferating layer. Thus, nm23 mRNA is differentially expressed, and the diverse NDPK isoforms are sequentially involved in various developmental processes.

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  1. EA DRED 483, Laboratoire de Biologie de la Différenciation et du Développement, Université Victor Ségalen, Bordeaux 2, 33 076, Bordeaux Cedex, France

    Lilian Amrein, Perrine Barraud, Jean-Yves Daniel & Yves Pérel

  2. INSERM E 358, Institut Francois Magendie, Université Bordeaux 2, 146, rue Léo Saignat, 33 077, Bordeaux Cedex, France

    Marc Landry

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  1. Lilian Amrein
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  2. Perrine Barraud
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  3. Jean-Yves Daniel
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Correspondence to Marc Landry.

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Amrein, L., Barraud, P., Daniel, JY. et al. Expression patterns of nm23 genes during mouse organogenesis. Cell Tissue Res 322, 365–378 (2005). https://doi.org/10.1007/s00441-005-0036-9

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