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Association of adipokines with cardiovascular risk factors in low birth weight children: a case–control study

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Abstract

Our aim was to investigate plasma levels of adiponectin, monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in low birth weight (LBW) children and to determine correlations among these adipokines and birth weight and cardiovascular disease risk factors. In a case–control study, the concentrations of adiponectin, MCP-1 and PAI-1 were measured in 180 schoolchildren (ages 6–11 years). MCP-1 and PAI-1 levels were significantly elevated in LBW children. Conversely, adiponectin concentration was significantly reduced in these children. Similar findings were observed after adjustment for current age, gender and abdominal circumference. Because the children with LBW had altered adipokine levels, as well as higher abdominal circumference, HOMA-IR and systolic blood pressure (SBP), we evaluated the correlation among these variables. These analyses showed that adiponectin levels were inversely correlated with systolic blood pressure (SBP) (r = −0.501; P < 0.001), HOMA-IR (r = −0.293; P = 0.023) and waist circumference (r = −0.317; P = 0.014). The proinflammatory markers were positively correlated with HOMA-IR (PAI-1: r = 0.358; P = 0.005) and waist circumference (PAI-1: r = 0.571; P < 0.001 and MCP-1: r = 0.267; P = 0.039). Conclusion: Adipokines levels were correlated with cardiovascular risk factors in LBW children, and these compounds could be involved in the mechanism that links birth weight to the development of cardiovascular diseases in adulthood.

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Acknowledgment

This research has been supported by FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil). Project numbers 08/58963-0 (MWLS) and 07/58044-2 (MCPF).

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None declared.

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Authors and Affiliations

  1. Department of Pediatrics, School of Medicine, Federal University of Sao Paulo, Rua Botucatu, 598, Sao Paulo, Sao Paulo, Brazil, CEP 04023-062

    Maria Wany Louzada Strufaldi, Rosana Fiorini Puccini & Olga Maria Amâncio Silvério

  2. Division of Nephrology, Department of Physiology, School of Medicine, Federal University of São Paulo, Sao Paulo, Brazil

    Maria Carmo do Pinho Franco

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  1. Maria Wany Louzada Strufaldi
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  2. Rosana Fiorini Puccini
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  3. Olga Maria Amâncio Silvério
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  4. Maria Carmo do Pinho Franco
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Correspondence to Maria Wany Louzada Strufaldi.

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Strufaldi, M.W.L., Puccini, R.F., Silvério, O.M.A. et al. Association of adipokines with cardiovascular risk factors in low birth weight children: a case–control study. Eur J Pediatr 172, 71–76 (2013). https://doi.org/10.1007/s00431-012-1846-x

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  • DOI: https://doi.org/10.1007/s00431-012-1846-x

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