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Retinal neurovascular coupling in patients with glaucoma and ocular hypertension and its association with the level of glaucomatous damage

  • Glaucoma
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To analyze neurovascular coupling in the retina of untreated primary open-angle glaucoma (POAG) and ocular hypertension (OHT) patients.

Patients and methods

Maximal vessel dilation in response to flicker light was analyzed with Retinal Vessel Analyzer (RVA) in temporal superior/inferior arterioles and veins in 51 POAG patients, 46 OHT and 59 control subjects. RVA parameters were compared between groups, between contralateral POAG eyes, and correlated to intraocular pressure, visual field mean defect and retinal nerve fiber layer thickness.

Results

POAG eyes demonstrated generally smaller response of all vessels to flicker light than the other two groups (ANOVA p = 0.026; mean arterial flicker response in percent of baseline, averaged superior and inferior was 3.48 ± 2.22 % for controls , 2.35 ± 2.06 % for POAG patients , and 2.97 ± 2.35 % for OHT patients; corresponding values for venules were 3.88 ± 1.98 %, 2.89 ± 1.72 %, 3.45 ± 2.77 %). There was no difference in flicker response between the eye with more and less advanced damage in each patient of the POAG group (ANOVA p = 0.79). Correlation of flicker response to intraocular pressure (IOP) was borderline at best, correlations to the level of glaucomatous damage were not significant. Correlation of flicker response of superior and inferior vessels of the same eye was significant for the arteries (Pearson r = 0.23, p = 0.004), as well as venules (r = 0.52, p < 0.001).

Conclusion

General vessel response to flicker light was decreased in POAG patients, compared to normal controls and OHT patients. In contrast to significant correlation between the two contralateral eyes of the flicker response itself, only its borderline correlation to IOP was seen. There was no correlation to the level of damage, altogether indicating a systemic dysregulation phenomenon.

Grants

Swiss National Foundation Grant 3200B0-113685, Velux Stiftung Grant, Freie Akademische Gesellschaft (FAG) Grant, Pfizer Inc. Grant

Clinical trial registration reference number

ClinicalTrials.gov NCT00430209

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Authors and Affiliations

  1. Department of Ophthalmology, University Hospital Basel, University Basel, Mittlerestrasse 91, CH-4031, Basel, Switzerland

    K. Gugleta, N. Waldmann, A. Polunina, A. Kochkorov, R. Katamay, J. Flammer & S. Orgul

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  1. K. Gugleta
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  2. N. Waldmann
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  3. A. Polunina
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  4. A. Kochkorov
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  5. R. Katamay
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  6. J. Flammer
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  7. S. Orgul
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Correspondence to K. Gugleta.

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Authors have full control of all primary data and agree to allow Graefes Archive for Clinical and Experimental Ophthalmology to review their data upon request.

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Gugleta, K., Waldmann, N., Polunina, A. et al. Retinal neurovascular coupling in patients with glaucoma and ocular hypertension and its association with the level of glaucomatous damage. Graefes Arch Clin Exp Ophthalmol 251, 1577–1585 (2013). https://doi.org/10.1007/s00417-013-2276-9

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  • DOI: https://doi.org/10.1007/s00417-013-2276-9

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