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Morphometry demonstrates loss of cortical thickness in cerebral microangiopathy

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Abstract

Objective

To evaluate the role of MR morphometry in the characterization of cerebral microangiopathy (CMA) in relation to clinical and neuropsychological impairment.

Subjects and Methods

3D MR images of 27 patients and 27 age–matched controls were morphometrically analysed for regional thickness. The normalized values were related to the patients’ clinical and neuropsychological scores. The patients were categorised according to the amount of structural MR signal changes. A ventricle index reflecting internal atrophy was related to MR morphology and cortical thickness as an indicator for external atrophy.

Results

Cortical thickness was significantly reduced in the patients group (3.03mm ± 0.26 vs. 3.22mm ± 0.13 in controls, p = 0.001). The severest loss of cortical thickness occurred in severe CMA. Internal and external atrophy evolved in parallel and both showed a significant relationship with structural MR–abnormalities (p < 0.05; r = –0.7; r = 0.67; r = –0.74, respectively). Neuropsychological performance correlated strongly with the loss of cortical thickness.

Conclusions

Cortical thickness was identified as the most sensitive parameter to characterize CMA. A strong correlation was found of morphometric parameters to the severity of CMA based on a score derived from T2–weighted MRI. The degree of cortical atrophy was directly related to the degree of neuropsychological impairment. Our findings suggest that the cortical thickness is a valid marker in the structural and clinical characterization of CMA.

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Authors and Affiliations

  1. Max-Planck-Institute of Human Cognitive and Brain Sciences, Stephanstraße 1a, 04103, Leipzig, Germany

    C. Preul MD, G. Lohmann PhD, M. Hund–Georgiadis MD & D. Y. von Cramon MD, PhD

  2. Day–Care Clinic of Cognitive Neurology, University Hospital of Leipzig, Leipzig, Germany

    T. Guthke PhD & D. Y. von Cramon MD, PhD

Authors
  1. C. Preul MD
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  2. G. Lohmann PhD
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  3. M. Hund–Georgiadis MD
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  4. T. Guthke PhD
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  5. D. Y. von Cramon MD, PhD
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Correspondence to C. Preul MD.

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Preul, C., Lohmann, G., Hund–Georgiadis, M. et al. Morphometry demonstrates loss of cortical thickness in cerebral microangiopathy. J Neurol 252, 441–447 (2005). https://doi.org/10.1007/s00415-005-0671-9

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  • DOI: https://doi.org/10.1007/s00415-005-0671-9

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