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Influence of abciximab on evolution of left ventricular function in patients with non-ST-segment elevation acute coronary syndromes undergoing PCI after clopidogrel pretreatment: lessons from the ISAR-REACT 2 trial

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Abstract

Background

Abciximab reduced the combined endpoint of death, myocardial infarction (MI) and target vessel revascularization in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) undergoing percutaneous coronary intervention (PCI) with stent implantation after a 600-mg loading dose of clopidogrel. The aim of the present study was to investigate the impact of abciximab on the evolution of left ventricular ejection fraction (LVEF) in these patients.

Methods

The current study included 1,158 patients enrolled in the randomized, double-blind ISAR-REACT 2 (the Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment) trial who had paired angiograms obtained at baseline and 6–8 months after randomization. Of them, 586 patients received abciximab and 572 patients received placebo. The primary outcome analysis was LVEF at 6–8-month follow-up.

Results

Baseline LVEF was comparable in patients assigned to abciximab or placebo (53.2 ± 12.6 vs. 53.7 ± 12.1%; P = 0.393). At 6–8-month follow-up angiography, there was no difference in LVEF between the abciximab and placebo groups (55.4 ± 11.5 vs. 55.8 ± 11.2%; P = 0.743). Subgroup analysis of patients with elevated baseline troponin (>0.03 μg/L) also revealed comparable LVEF at follow-up in both treatment groups (P = 0.527). The multivariate analysis identified age, arterial hypertension, prior MI, prior coronary artery bypass graft surgery, baseline LVEF, MI at 30 days and repeat PCI as independent correlates of follow-up LVEF.

Conclusion

Although abciximab reduced the 30-day and 1-year incidence of major adverse cardiac events in patients with NSTE-ACS undergoing primary PCI after pre-treatment with a 600-mg loading dose of clopidogrel, the agent did not improve or impact on the evolution of LVEF over 6–8 months of follow-up.

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Acknowledgments

The ISAR-REACT 2 trial was supported in part by the grant KKF 04-03 from Deutsches Herzzentrum, Munich, Germany.

Conflict of interest

AK has received honoraria from Eli Lilly, Astra-Zeneca and Bristol-Myers Squibb.

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Authors and Affiliations

  1. Deutsches Herzzentrum, Technische Universität, Lazarettstr. 36, 80636, Munich, Germany

    Stefanie Schulz, Julinda Mehilli, Gjin Ndrepepa, Michael Dommasch, Sebastian Kufner, Kathrin A. Birkmeier, Klaus Tiroch, Robert A. Byrne, Albert Schömig & Adnan Kastrati

  2. 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität, Ismaninger Str. 22, 81675, Munich, Germany

    Albert Schömig

  3. Klinikum Garmisch-Partenkirchen, Zentrum für Innere Medizin/Kardiologie, Auenstraße 6, 82467, Garmisch-Partenkirchen, Germany

    Franz Dotzer

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  1. Stefanie Schulz
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Correspondence to Stefanie Schulz.

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For the Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment 2 (ISAR-REACT 2) Trial Investigators.

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Schulz, S., Mehilli, J., Ndrepepa, G. et al. Influence of abciximab on evolution of left ventricular function in patients with non-ST-segment elevation acute coronary syndromes undergoing PCI after clopidogrel pretreatment: lessons from the ISAR-REACT 2 trial. Clin Res Cardiol 100, 691–699 (2011). https://doi.org/10.1007/s00392-011-0299-y

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