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Transcriptional regulation of mast cell and basophil lineage commitment

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Abstract

Basophils and mast cells have long been known to play critical roles in allergic disease and in immunity against parasitic infection. Accumulated evidence also supports that basophils and mast cells have important roles in immune regulations, host defense against bacteria and viruses, and autoimmune diseases. However, origin and molecular regulation of basophil and mast cell differentiation remain incompletely understood. In this review, we focus on recent advances in the understanding of origin and molecular regulation of mouse and human basophil and mast cell development. A more complete understanding of how basophils and mast cells develop at the molecular level will lead to development of interventions that are more effective in achieving long-term success.

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Abbreviations

BaPs:

Basophil lineage-restricted progenitors

BM:

Bone marrow

BMCPs:

Basophil/mast cell progenitors

C/EBPα:

CCAAT/enhancer binding protein alpha

CMA1:

Mast cell chymase 1

CMPs:

Common myeloid progenitors

CTMCs:

Connective tissue mast cells

EoBPs:

Eosinophil-basophil progenitors

FOG-1:

Friend of GATA protein 1

GATA1:

GATA-binding protein 1

GATA2:

GATA-binding protein 2

GMPs:

Granulocyte-monocyte progenitors

GPs:

Granulocyte progenitors

HSCs:

Hematopoietic stem cells

IL:

Interleukin

ILC2:

Type 2 innate lymphoid cells

IRF8:

Interferon regulatory factor 8

MCPs:

Mast cell lineage-restricted progenitors

MITF:

Microphthalmia-associated transcription factor

MMCs:

Mucosal mast cells

mMCP-1:

Mouse mast cell protease 1

MPPs:

Multiple potential progenitors

P1-RUNX1:

Distal promoter-derived Runt-related transcription factor 1

PB:

Peripheral blood

pre-BMPs:

Pre-basophil/mast cell progenitors

SL-CMPs:

Sca-1 low common myeloid progenitors

SL-GMPs:

Sca-1 low granulocyte-monocyte progenitors

STAT5:

Signal transducer and activator of transcription 5

TC2:

CD8+ cytotoxic type 2 cells

Th2:

CD4+ helper type 2 cells

TSLP:

Thymic stromal lymphopoietin

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Acknowledgments

This work is supported by grant from the National Institutes of Health (5R01AI107022-02).

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Authors and Affiliations

  1. Department of Biomedical Research, National Jewish Health, Denver, CO, 80206, USA

    Hua Huang, Yapeng Li & Bing Liu

  2. Department of Immunology and Microbiology, University of Colorado School of Medicine, Denver, CO, 80206, USA

    Hua Huang

  3. Department of Biomedical Research, National Jewish Health and Department of Immunology and Microbiology, University of Colorado School of Medicine, 1400 Jackson Street, Denver, CO, 80206, USA

    Hua Huang

  4. Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China

    Bing Liu

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  1. Hua Huang
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  2. Yapeng Li
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  3. Bing Liu
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Correspondence to Hua Huang.

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This article is a contribution to the special issue on Basophils and Mast Cells in Immunity and Inflammation - Guest Editor: Hajime Karasuyama

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Huang, H., Li, Y. & Liu, B. Transcriptional regulation of mast cell and basophil lineage commitment. Semin Immunopathol 38, 539–548 (2016). https://doi.org/10.1007/s00281-016-0562-4

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