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Long-Term Outcome of Laparoscopic Surgery for Pancreatic Neuroendocrine Tumors

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Abstract

Background

As most pancreatic neuroendocrine tumors (PNET) are relatively small and solitary, they may be considered well suited for removal by a minimally invasive approach. There are few large series that describe laparoscopic surgery for PNET. The primary aim of this study was to describe the feasibility, outcome, and histopathology associated with laparoscopic pancreatic surgery (LS) of PNET in a large series.

Methods

All patients with PNET who underwent LS at a single hospital from March 1997 to April 2011 were included retrospectively in the study.

Results

A total of 72 patients with PNET underwent 75 laparoscopic procedures, out of which 65 were laparoscopic resections or enucleations. The median operative time of all patients who underwent resections or enucleations was 175 (60–520) min, the median blood loss was 300 (5–2,700) ml, and the median length of hospital stay was 7 (2–27) days. The overall morbidity rate was 42 %, with a surgical morbidity rate of 21 % and postoperative pancreatic fistula (POPF) formation in 21 %. Laparoscopic enucleations were associated with a higher rate of POPF than were laparoscopic resections. Five-year disease-specific survival rate was 90 %. The T stage, R stage, and a Ki-67 cutoff value of 5 % significantly predicted 5-year survival.

Conclusion

LS of PNET is feasible with acceptable morbidity and a good overall disease-specific long-term prognosis.

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Acknowledgments

The authors thank Krzysztof Grzyb, MD, for playing an important role in the histopathological assessment of the surgical specimens. The sources of support behind this study came from Oslo University Hospital. There were no other sources of support.

Conflict of interest

The authors have no conflicts of interest to disclose.

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Authors and Affiliations

  1. Department of Hepato-Pancreato-Biliary Surgery, Rikshospitalet, Oslo University Hospital, Sognsvannsveien 20, 0372, Oslo, Norway

    Sven-Petter Haugvik, Bård Ingvald Røsok, Ewa Pomianowska, Ivar Prydz Gladhaug, Øystein Mathisen & Bjørn Edwin

  2. Institute of Clinical Medicine, University of Oslo, Kirkeveien 166, 0450, Oslo, Norway

    Sven-Petter Haugvik, Ewa Pomianowska, Ivar Prydz Gladhaug & Bjørn Edwin

  3. Interventional Centre, Rikshospitalet, Oslo University Hospital, Sognsvannsveien 20, 0372, Oslo, Norway

    Irina Pavlik Marangos & Bjørn Edwin

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  1. Sven-Petter Haugvik
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Correspondence to Sven-Petter Haugvik.

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Haugvik, SP., Marangos, I.P., Røsok, B.I. et al. Long-Term Outcome of Laparoscopic Surgery for Pancreatic Neuroendocrine Tumors. World J Surg 37, 582–590 (2013). https://doi.org/10.1007/s00268-012-1893-5

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