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The relationship between low bone mass and metabolic syndrome in Korean women

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Abstract

Summary

We examined the relationship between low bond mass and metabolic syndrome in 2,475 Korean women. After adjustment for all covariates, mean vertebral BMD was significantly lower in women with metabolic syndrome. Moreover, age and weight adjusted vertebral BMD was significantly decreased with additional components of the metabolic syndrome.

Introduction

Obesity-induced chronic inflammation is a key component in the pathogenesis of insulin resistance and metabolic syndrome. It has been suggested that proinflammatory cytokines and low-grade systemic inflammation activate bone resorption and may lead to reduced bone mineral density (BMD). The objective of this study was to determine the relationship between low bone mass and metabolic syndrome in Korean women.

Methods

This is a cross-sectional study of 2,548 women aged 18 years and over who had visited the Health Promotion Center. Physical examination and laboratory tests were performed. Vertebral BMD was measured using dual-energy X-ray absorptiometry. Metabolic syndrome was defined by National Cholesterol Education Program—Adult Treatment Panel III criteria.

Results

Among 2,475 women, 511 (21.0%) women had metabolic syndrome. Women with abdominal obesity or hypertriglyceridemia had significantly lower vertebral BMD than women without respective components after adjustment for age, weight, and height. After adjustment for all covariates, mean vertebral BMD was significantly lower in women with metabolic syndrome (p = 0.031). Moreover, age- and weight-adjusted vertebral BMD were significantly decreased with additional components of the metabolic syndrome (p = 0.004).

Conclusions

These findings suggest that metabolic syndrome might be another risk factor for osteoporosis and related fractures.

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Acknowledgements

This work was supported in part by The Korean Society of Menopause Grant.

Conflicts of interest

None.

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Authors and Affiliations

  1. Family Medicine, Eulji University Hospital, Daejeon, South Korea

    D.-K. Hwang

  2. Family Medicine, Eulji University School of Medicine, Daejeon, South Korea

    H.-J. Choi

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  1. D.-K. Hwang
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  2. H.-J. Choi
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Correspondence to H.-J. Choi.

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Hwang, DK., Choi, HJ. The relationship between low bone mass and metabolic syndrome in Korean women. Osteoporos Int 21, 425–431 (2010). https://doi.org/10.1007/s00198-009-0990-2

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  • DOI: https://doi.org/10.1007/s00198-009-0990-2

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