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Linkage disequilibrium and sequence diversity in a 500-kbp region around the adh1 locus in elite maize germplasm

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Abstract

Linkage disequilibrium (LD) at the adh1 locus was examined in two sets of maize inbreds. A set of 32 was chosen to represent most of the genetic diversity in the cultivated North American elite maize breeding pool. A second set of 192 inbreds was chosen to sample more deeply the two major heterotic groups in elite maize germplasm. Analysis of several loci in the vicinity of the adh1 gene shows that LD as measured by D′ and r2 extends greater than 500 kbp in this germplasm. The presence of this exceptionally long segment of high LD may be suggestive of selection acting on one of the genes in the vicinity of adh1 or of a locally reduced rate of recombination.

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Acknowledgements

We thank Steve Wall, Mike Hanafey, Stan Luck, Romeo Hubner, Nancy Caraher, Howie Smith, David Meyer, Marianna Faller, and Michael Gore for helpful advice and analysis support. We also thank Ed Buckler help with data analysis and comments on the manuscript.

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Authors and Affiliations

  1. DuPont Crop Genetics, Experimental Station, P.O. Box 80353, Wilmington, DE, 19880-0353, USA

    Mark Jung, Ada Ching, Maureen Dolan, Scott Tingey, Michele Morgante & Antoni Rafalski

  2. Pioneer Hi-Bred International, Inc., 7300 NW 62nd Avenue, P.O. Box 1004, Johnston, IA, 50131-1004, USA

    Dinakar Bhattramakki

  3. Dipartimento di Produzione Vegetale e Tecnologie Agrarie, Universita’ di Udine, Via delle Scienze 208, 33100, Udine, Italy

    Michele Morgante

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  1. Mark Jung
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  2. Ada Ching
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  3. Dinakar Bhattramakki
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  4. Maureen Dolan
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  5. Scott Tingey
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  6. Michele Morgante
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  7. Antoni Rafalski
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Correspondence to Mark Jung.

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Communicated by F. Salamini

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Jung, M., Ching, A., Bhattramakki, D. et al. Linkage disequilibrium and sequence diversity in a 500-kbp region around the adh1 locus in elite maize germplasm. Theor Appl Genet 109, 681–689 (2004). https://doi.org/10.1007/s00122-004-1695-8

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  • DOI: https://doi.org/10.1007/s00122-004-1695-8

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