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A fat attack occurred in fat city

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References

  1. Olshansky SJ, Passaro DJ, Hershow RC, Layden J, Carnes BA, Brody J, Hayflick L, Butler RN, Allison DB, Ludwig DS (2005) A potential decline in life expectancy in the United States in the 21st century. N Engl J Med 352:1138–1145

    Article  PubMed  Google Scholar 

  2. Berg AH, Scherer PE (2005) Adipose tissue, inflammation, and cardiovascular disease. Circ Res 96:939–949

    Article  PubMed  Google Scholar 

  3. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF (1995) A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270:26746–26749

    Article  PubMed  Google Scholar 

  4. Nawrocki AR, Scherer PE (2005) Keynote review: the adipocyte as a drug discovery target. Drug Discov Today 10:1219–1230

    Article  PubMed  Google Scholar 

  5. Kadowaki T, Yamauchi T (2005) Adiponectin and adiponectin receptors. Endocr Rev 26:439–451

    Article  PubMed  Google Scholar 

  6. Iyengar P, Espina V, Williams TW, Lin Y, Berry D, Jelicks LA, Lee H, Temple K, Graves R, Pollard J, Chopra N, Russell RG, Sasisekharan R, Trock BJ, Lippman M, Calvert VS, Petricoin EF III, Liotta L, Dadachova E, Pestell RG, Lisanti MP, Bonaldo P, Scherer PE (2005) Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment. J Clin Invest 115:1163–1176

    Article  PubMed  Google Scholar 

  7. Combs TP, Nagajyothi, Mukherjee S, de Almeida CJ, Jelicks LA, Schubert W, Lin Y, Jayabalan DS, Zhao D, Braunstein VL, Landskroner-Eiger S, Cordero A, Factor SM, Weiss LM, Lisanti MP, Tanowitz HB, Scherer PE (2005) The adipocyte as an important target cell for Trypanosoma cruzi infection. J Biol Chem 280:24085–24094

    Article  PubMed  Google Scholar 

  8. Pajvani UB, Trujillo ME, Combs TP, Iyengar P, Jelicks L, Roth KA, Kitsis RN, Scherer PE (2005) Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy. Nat Med 11:797–803

    Article  PubMed  Google Scholar 

  9. Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, Lass A, Neuberger G, Eisenhaber F, Hermetter A, Zechner R (2004) Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306:1383–1386

    Article  PubMed  Google Scholar 

  10. Langin D, Dicker A, Tavernier G, Hoffstedt J, Mairal A, Ryden M, Arner E, Sicard A, Jenkins CM, Viguerie N, van Harmelen V, Gross RW, Holm C, Arner P (2005) Adipocyte lipases and defect of lipolysis in human obesity. Diabetes 54:3190–3197

    PubMed  Google Scholar 

  11. Kratky D, Zimmermann R, Wagner EM, Strauss JG, Jin W, Kostner GM, Haemmerle G, Rader DJ, Zechner R (2005) Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue. J Clin Invest 115:161–167

    Article  PubMed  Google Scholar 

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Correspondence to Friedrich C. Luft.

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Luft, F.C. A fat attack occurred in fat city. J Mol Med 84, 1–3 (2006). https://doi.org/10.1007/s00109-005-0725-6

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  • DOI: https://doi.org/10.1007/s00109-005-0725-6

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