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Versorgung einer schwangeren Patientin nach Polytrauma

Seltene Kombination mit thrombotisch-thrombozytopenischer Purpura

Treatment of a pregnant patient after multiple trauma

Rare combination with thrombotic thrombocytopenic purpura

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Zusammenfassung

Der eher seltene Fall einer schwangeren Frau mit Polytrauma stellt eine große Herausforderung für das behandelnde Team dar. Eine begleitende thrombotisch-thrombozytopenische Purpura (TTP), die über die thrombozytäre Gerinnungsstörung deutlich in Behandlungsverlauf und Homöostase eingreift, macht die posttraumatische Versorgung komplex. Im Rahmen eines Polytraumas erlitt die vorgestellte Patientin eine schwere Leberruptur. Nach initialer Stabilisierung über eine Notsectio und ein „Leber-Packing“ kam es nach dem „depacking“ zu einer abdominellen Blutung, die mit der Gabe von rekombinantem Faktor VIIa erfolgreich behandelt werden konnte. Die begleitende Behandlung der TTP erfolgte über die Transfusion von gefrorenem Frischplasma und eine immunsupressive Therapie mit Kortison. Trotz schwerer Thrombozytopenie konnte durch den frühen Therapiebeginn ein schwerer klinischer Verlauf verhindert werden.

Abstract

Multiple trauma during pregnancy is a relatively rare situation which poses a great challenge for the team in charge of treatment. A concomitant disease, such as thrombotic thrombocytopenic purpura (TTP) with thrombocytic coagulopathy increases the complexity of the treatment problems. This article describes the case of a 36-year-old pregnant woman referred to this hospital suffering from multiple trauma with severe liver rupture. Stabilization was achieved after an emergency Caesarean section and packing of the liver. Recurrent massive bleeding from the liver occurred after depacking and was treated successfully with recombinant factor VIIa. The concomitant TTP was treated by transfusion of fresh frozen plasma and corticosteroids. Rapid initiation of therapy was the goal to achieve hemostasis and prevent aggravation of the coagulation disorder and an unfavourable outcome despite severe thrombocytopenia.

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Haffner, E., Pietsch, U., Fösel, T. et al. Versorgung einer schwangeren Patientin nach Polytrauma. Anaesthesist 62, 125–129 (2013). https://doi.org/10.1007/s00101-012-2130-1

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  • DOI: https://doi.org/10.1007/s00101-012-2130-1

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