Abstract
Treatment of 6-alkyl-1-phenyl-4-chloro-(1H)-pyrazolo[3,4-d]pyrimidines, with different amines afforded a series of compounds whose identity and purity were confirmed by spectral and analytical means. The compounds were tested for antibacterial activity against four organisms viz. Staphylococcus aureus (Gram positive), S. epidermidis (Gram positive), Bacillus subtilis (Gram positive), Escherichia coli (Gram negative) using amoxicillin as standard control. Compounds 4d, 6b, 6c have shown best antibacterial activity in the series. The antiproliferative activity was tested against human skin cancer cell line G361. The compounds 3d, 4d, 5b, 5d, 5e, 6c, 7a were found to be the best of the series and showed the activity at micromolar concentration.
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Acknowledgments
Dr. MRP gratefully acknowledges the support rendered by Department of Science and Technology, New Delhi in the form of Fast Track Fellowship for Young Scientists [SR/FTP/CS-59/2007]. Authors thank Shri K. V. Vishnu Raju, Chairman and Shri K. Srinivas Reddy, Dean, Shri Vishnu Educational Society and Dr. D. B. Raju, Principal, Shri Vishnu College of Pharmacy for providing infrastructural facilities to carry out the research work. Authors thank Tata Memorial Centre [Advanced Centre for Treatment Research and Education in Cancer (ACTREC)], Mumbai to carry out anticancer activity.
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Devarakonda, M., Doonaboina, R., Vanga, S. et al. Synthesis of novel 2-alkyl-4-substituted-amino-pyrazolo[3,4-d]pyrimidines as new leads for anti-bacterial and anti-cancer activity. Med Chem Res 22, 1090–1101 (2013). https://doi.org/10.1007/s00044-012-0084-0
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DOI: https://doi.org/10.1007/s00044-012-0084-0