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The Evolutionary Role of the IL-33/ST2 System in Host Immune Defence

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Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

Interleukin (IL)-33 is a recently identified pleiotropic cytokine, which can orchestrate complex innate and adaptive immune responses in immunity and disease. It has been characterized as a cytokine of the IL-1 family and affects a wide range of immune cells by signalling through its receptor ST2L. Accumulating evidence suggests a crucial role of IL-33/ST2 in inducing and modifying host immune responses against a variety of pathogens including parasites, bacteria, viruses and fungi as well as sterile insults of both endogenous and exogenous source. In this review, we endeavour to give a comprehensive overview of the current knowledge about the role of IL-33 and its receptor ST2 in host defence against infections.

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Authors and Affiliations

  1. Department of Medicine, Centre for Complement and Inflammation Research, Imperial College London, Hammersmith Campus, Du Cane Road, W12 0NN, London, UK

    Susanne Sattler & Fang-Ping Huang

  2. Cellular Immunology of Parasitic Infections Group, Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands

    Hermelijn H. Smits

  3. Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK

    Damo Xu

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  1. Susanne Sattler
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  2. Hermelijn H. Smits
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  3. Damo Xu
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  4. Fang-Ping Huang
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Correspondence to Susanne Sattler.

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Sattler, S., Smits, H.H., Xu, D. et al. The Evolutionary Role of the IL-33/ST2 System in Host Immune Defence. Arch. Immunol. Ther. Exp. 61, 107–117 (2013). https://doi.org/10.1007/s00005-012-0208-8

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  • DOI: https://doi.org/10.1007/s00005-012-0208-8

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