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Molecular Biology of Metal Homeostasis and Detoxification

From Microbes to Man

  • Book
  • © 2006

Overview

  • A milestone in metal biology
  • Addresses both essential and toxic metals and looks at their effects in a range of different organisms
  • A must have for postgraduates and researchers alike
  • Includes supplementary material: sn.pub/extras

Part of the book series: Topics in Current Genetics (TCG, volume 14)

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Table of contents (14 chapters)

Keywords

About this book

One of the challenges faced by every cell as well as by whole organisms is to maintain appropriate concentrations of essential nutrient metals while excluding nonessential toxic metals. Toward that end, all organisms have developed mechanisms for metal homeostasis and detoxification to maintain metal levels within physiological limits. This book brings together current knowledge of the molecular basis of metal homeostasis and detoxification in various eukaryotic model systems, including yeasts, plants, and mammals. It focuses on the cellular systems controlling metal transport, intracellular distribution, and immobilization as well as on systems regulating metal-dependent transcription. In addition to environmental aspects (including phytoremediation), the book treats the pathophysiology of metal deficiency and overload in relation to disease.

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