Abstract
In this study, we report the synthesis and antimicrobial evaluation of several new thiazolo[4,5-d] pyrimidine derivatives, namely 7-substituted amino-5-methyl-3-phenylthiazolo[4,5-d]pyrimi-dine-2 (3H)-thiones4a- e,8,13,15, ethyl 2-cyano-2-(7-substituted-5-methyl-3-phenylthiazolo [4,5-d]-pyrimidin-2(3H)-ylidene)acetates5a- b, 2-(7-substituted-5-methyl-3-phenylthiazolo[4,5-d] pyrimidin-2(3H)-ylidene)malononitriles6a- b, 5-methyl-7-morpholino-3-phenylthiazolo[4,5-d] pyrimidine-2(3H)-one 7, and 7-[4-(1-substituted-5-phenyl-4,5-dihydro-1H-pyrazolin-3-yl)anilino]-5-methyl-3-phenylthiazolo[4,5-d]pyrimidine-2(3H)-thiones10- 12. Some of the tested compounds were more active againstC. albicans thanE. coli andP. aeruginosa, and all were inactive against S.aureus.
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Habib, N.S., Soliman, R., El-Tombary, A.A. et al. Synthesis of thiazolo[4,5-d]pyrimidine derivatives as potential antimicrobial agents. Arch Pharm Res 30, 1511–1520 (2007). https://doi.org/10.1007/BF02977319
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DOI: https://doi.org/10.1007/BF02977319