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Zonation of metabolism and gene expression in liver

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Conclusion

The zonation of gene expression resulting in the different cellular equipment of liver cells with enzymes, translocators and subcellular structures is regulated mainly at a pretranslational level. In the dynamic zonation of carbohydrate metabolizing enzymes, gradients in oxygen and in the glucagon/insulin ratio decreasing from the periportal to the perivenous area appear to be major effectors. In the stable zonation of ammonia-metabolizing enzymes local paracrine cell-cell interactions via diffusible mediators could play a major role (Fig. 6).

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  1. Institut für Biochemie und Molekulare Zellbiologie, Georg-August Universität, Humboldtallee 23, D-37073, Göttingen, Germany

    Kurt Jungermann

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Jungermann, K. Zonation of metabolism and gene expression in liver. Histochem Cell Biol 103, 81–91 (1995). https://doi.org/10.1007/BF01454004

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