Summary
Male and female mice were treated with methamphetamine (10.0 mg/kg/injection for four injections) and sacrificed two weeks later. It was observed that the methamphetamine treatment caused depletions in striatal dopamine which were significantly greater in males (74%) than in females (56%). These results indicate that estrogen may have a protective effect against methamphetamine-induced dopamine depletions and may relate to the fact that males are more likely to incur Parkinson's disease than females.
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Wagner, G.C., Tekirian, T.L. & Cheo, C.T. Sexual differences in sensitivity to methamphetamine toxicity. J. Neural Transmission 93, 67–70 (1993). https://doi.org/10.1007/BF01244939
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DOI: https://doi.org/10.1007/BF01244939