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The 5-HT1A receptor: an overview of recent advances

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Abstract

Progress in the field of neuronal receptor research has accelerated during the last few years due to developments in pharmacology and molecular biology. This is particularly true in the case of the serotonin 5-HT1A receptor. In 1983 the very selective, high affinity 5-HT1A agonist 8-OH-DPAT was developed which allowed the pharmacology and distribution of the 5-HT1A receptor in the central nervous system of the rat and man to be extensively characterized. By 1987, the gene encoding this receptor protein was cloned and sequenced, allowing not only elucidation of its structure, but also better insight into the nature of its coupling to transmembrane signal transduction systems. Thus in a short period of time considerable knowledge has accumulated on how serotonin exerts its functions in the central nervous system via the 5-HT1A receptor. In the present review we will briefly discuss some of the latest developments regarding the 5-HT1A receptor.

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Authors and Affiliations

  1. INSERM U288, Neurobiologie cellulaire et fonctionnelle, Facultéde Médecine Pitié-Salpêtrière, Paris, France

    Salah El Mestikawy & Henri Gozlan

  2. Dept. of Medicine (Cardiology), Duke University Medical Center, 27710, Durham, N.C., USA

    Salah El Mestikawy, Annick Fargin & Mark Hnatowich

  3. Department of Medicine (Nephrology), Duke University Medical Center, 27710, Durham, N.C., USA

    John R. Raymond

  4. Department of Veterans Affairs Medical Center, 27710, Durham, N.C., USA

    John R. Raymond

  5. Howard Hughes Medical Institute, 27710, Durham, N.C., USA

    Salah El Mestikawy, Annick Fargin, John R. Raymond & Mark Hnatowich

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Mestikawy, S.E., Fargin, A., Raymond, J.R. et al. The 5-HT1A receptor: an overview of recent advances. Neurochem Res 16, 1–10 (1991). https://doi.org/10.1007/BF00965820

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