Summary
Early detection of ototoxicity is of vital importance in cases in which ototoxic drugs are administered. Ototoxicity as a result of cis-platinum administration is well documented. Auditory damage may be reduced by changes in dose, drugs or methods of treatment. As ototoxicity appears to be most pronounced in the higher frequencies of sound, any changes can be assessed at an earlier stage by using high-frequency audiometry to test patients at frequencies from 8 to 20 kHz. Our present study demonstrates the utility of monitoring auditory function at frequencies higher than conventionally tested in patients receiving cis-platinum.
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References
Bägger-Sjöback D, Filipek CS, Schacht J (1980) Characteristics and drug responses of cochlear and vestibular adenylate cyclase. Arch Otorhinolaryngol 228:217–222
Dreschler WA, Van der Hulst RJAM, Tange RA (1984) Ototoxicity and the role of high-frequency audiometry. J Acoust Soc Am [Suppl 1] 76:74
Fausti SA, Frey RH, Erickson DA, Rappaport BZ, Cleary EJ, Brummett RE (1979) A system for evaluating auditory function from 8000–20000 Hz. J Acoust Soc Am 66 (6):1713–1718
Fausti SA, Schechter MA, Rappaport BZ, Frey RH, Mass RE (1984) Early detection of cis-platinum Ototoxicity. Cancer 53:224–231
Fleischmann RW, Stadnicki SW, Ethier MF, Schaeppi U (1975) Ototoxicity of cis-dichlorodiamimine platinum II in the guinea pig. Toxicol Appl Pharmacol 33:320–332
Hartwig W, Petterson U, Stahle J (1983) Cis-diaminminedichloro platinum: a cytostatic with ototoxic effect. ORL 45:257–261
Helson L, Okonkwo E, Anton L, Cvitkovic E (1978) Cis-platinum Ototoxicity. Clin Toxicol 13 (4):469–478
Jacobson EJ, Downs MP, Fletcher JC (1969) Clinical findings in high-frequency thresholds during ototoxic usage. J Aud Res 9:379–385
Lerner SA, Matz GJ (1979) Suggestions for monitoring patients during treatment with aminoglycosides antibiotics. Otolaryngol Head Neck Surg 87:222–228
Lerner SA, Matz GJ, Hawkins JE Jr (1981) Aminoglycoside Ototoxicity. Little Brown and Company, Boston
Piel IJ, Meyer D, Perla CP, Wolfe V (1974) Effects of cis-diamiminedichloro platinum II on hearing function in man. Cancer Chemother Rep 58:871–875
Tange RA, Huizing EH (1980) Hearing loss and inner ear changes in a patient suffering from severe gentamicin Ototoxicity. Arch Otorhinolaryngol 228:113–121
Tange RA, Vuzevski VD (1984) Changes in the stria vascularis of the guinea pig due to cis-platinum. Arch Otorhinolaryngol 239:1:41–48
Tange RA, Conijn EAJG, Van Zeyl PGPM (1982) The cortitoxic effects of cis-platinum in the guinea pig. Arch Otorhinolaryngol 237:17–26
Van Zeyl LGPM, Conijn EAJG, Rodenburg M, Tange RA, Brocaar MP (1984) Analysis of hearing losses due to cis-diamiminedichloro platinum II. Arch Otorhinolaryngol 239:255–262
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Tange, R.A., Dreschler, W.A. & van der Hulst, R.J.A.M. The importance of high-tone audiometry in monitoring for ototoxicity. Arch Otorhinolaryngol 242, 77–81 (1985). https://doi.org/10.1007/BF00464411
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DOI: https://doi.org/10.1007/BF00464411