Abstract
This symposium focuses on the mechanics of heart muscle contraction, ventricular pump function, and central hemodynamics. Therefore, despite the title, this chapter confines itself to discussions on the mechanical interactions between the heart and the vasculature with special reference to physiological optimizations of their coupling. Such basic knowledge on the interactions is prerequisite for quantitative understanding of the neural and humoral controls of the circulatory system. Take arterial baroreceptor reflex control of ventricular contractility for example. It has repeatedly been observed that reduction of pressure in the isolated baroreceptor does not significantly increase cardiac output even though there is an obvious reflex pressor response. This apparent lack in cardiac response may only be apparent because the reflex augmentation of the contractility may be just enough to overcome the reflex-induced increase in peripheral resistance and hence to maintain cardiac output [1]. Only when the basic mechanics of the interaction between the ventricle and the arterial system are clearly understood, can the true reflex effect on, cardiac contractility be appreciated from the measured change in cardiac output.
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Sagawa, K., Sunagawa, K., Burkhoff, D., Alexander, J. (1987). Control of the circulation. In: Ter Keurs, H.E.D.J., Tyberg, J.V. (eds) Mechanics of the Circulation. Developments in Cardiovascular Medicine, vol 69. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3311-8_23
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DOI: https://doi.org/10.1007/978-94-009-3311-8_23
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