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Stem Cells and Cancer Stem Cells, Volume 11 pp 189–200Cite as

Hematopoietic Stem Cells and Bone Regeneration

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Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 11))

Abstract

The mechanisms of therapeutic regeneration of osseous tissue in field of orthopedics still remain elusive. Not only cytokines, growth factors, terminally differentiated cells, and mechanical factors play role in etiology of bone functioning but also the numbers, and functionality of stem cells play critical role in bone regeneration and maintenance of bone health. Thus, regeneration of bone tissue using stem cells promises an efficient therapeutic approach for lost or traumatized bone tissue. This chapter emphasizes the factors regulating plasticity of hematopoietic stem cells to trans-differentiate into unconventional cell lineages and osteoblastic lineage. We discuss about the therapeutic application of stem cells of hematopoietic and non-hematopoietic origin for regeneration of bones in the preclinical and clinical setting. We also provide evidences of the use of hematopoietic stem cells for bone regeneration, particularly in osteoporotic bone diseases.

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Acknowledgements

This work was supported in part by National Institutes of Health grants, K01 AR054114 (NIAMS), SBIR R44 HL092706-01 (NHLBI), R21 CA143787 (NCI), and The Ohio State University start-up fund for stem cell research. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.

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Authors and Affiliations

  1. Cardiovascular Stem Cell Research Laboratories, Davis Heart and Lung Research Institute, BRT, 460 W 12th Avenue, Columbus, OH, USA

    Reeva Aggarwal, Vincent J. Pompili & Hiranmoy Das

Authors
  1. Reeva Aggarwal
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  2. Vincent J. Pompili
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  3. Hiranmoy Das
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Correspondence to Hiranmoy Das .

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Editors and Affiliations

  1. Department of Biological Sciences, Kean university, Room 213, Library Building, Union, New Jersey, USA

    M.A. Hayat

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Aggarwal, R., Pompili, V.J., Das, H. (2014). Hematopoietic Stem Cells and Bone Regeneration. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 11. Stem Cells and Cancer Stem Cells, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7329-5_16

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