Abstract
The malignancy of tumors is often explained by the presence of cancer stem cells, which are considered resistant to anti-cancer agents and radiation. Cancer stem cells are typically characterized by continuous proliferation and self-renewal as well as by potential of differentiation. Stem cells are considered to differentiate into tissue specific phenotype of mature cells being influenced by the microenvironment. In this context, cancer stem cells should be derived from the stem cells under the influence of a microenvironment, which induces malignant tumors. In this review, we propose this microenvironment as a ‘cancerous niche’ and discuss its importance on the formation and maintenance of cancer stem cells with the recent experimental results to establish cancer stem cell models from induced pluripotent stem cells. These models of cancer stem cell will provide the great advantages in cancer research and its applications in the future.
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Murakami, H. et al. (2014). Cancer Stem Cells Derived from Mouse Induced Pluripotent Stem Cells. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 11. Stem Cells and Cancer Stem Cells, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7329-5_11
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DOI: https://doi.org/10.1007/978-94-007-7329-5_11
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