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Colon Cancer Stem Cells: A Therapeutic Target

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Book cover Stem Cells and Cancer Stem Cells, Volume 8

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 8))

Abstract

Cancer stem cells (CSCs), that are resistant to chemotherapy, are the major obstacle in treatment of different cancers including colorectal cancer. Recently, markers of CSCs have been identified. CD133, CD44, CD166, ALDH1A1, Lgr5, and several other proteins have been proposed as CSC markers. In this review article, we have discussed several therapeutic strategies that may target the self-renewal pathways, miRNAs and other epigenetic modifiers in colon CSCs to arrest and/or regress recurrent colon cancer.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, Wayne State University School of Medicine, John D Dingell VA Medical Centre, 4646 John R Street, Detroit, MI, 48201, USA

    Sanchita Roy

  2. Department of Internal Medicine, Karmanos Cancer Institute, Wayne State University School of Medicine, John D Dingell VA Medical Centre, 4646 John R Street, Detroit, MI, 48201, USA

    Adhip P. N. Majumdar

Authors
  1. Sanchita Roy
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  2. Adhip P. N. Majumdar
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Corresponding author

Correspondence to Adhip P. N. Majumdar .

Editor information

Editors and Affiliations

  1. Biology, Kean University, Union, New Jersey, USA

    M.A. Hayat

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© 2012 Springer Science+Business Media Dordrecht

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Roy, S., Majumdar, A.P.N. (2012). Colon Cancer Stem Cells: A Therapeutic Target. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 8. Stem Cells and Cancer Stem Cells, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4798-2_20

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