Skip to main content
SpringerLink
Log in

Mesenchymal Stem Cells for the Treatment of Cancer

  • Chapter
  • First Online:
Book cover Stem Cells and Cancer Stem Cells, Volume 6

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 6))

  • 1302 Accesses

Abstract

Mesenchymal stem cells (MSCs) may be used for treating patients with cancers. Several groups are developing different strategies exploiting the capacity of intravenously infused MSCs for targeting tumors, and their ability for carrying and delivering anticancer molecules. In this chapter we will present a summary on the works that have addressed the possibilities and potentials of MSCs as therapeutic elements against tumors, underscoring the implications for patients suffering from cancers.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Alm JJ, Koivu HM, Heino TJ, Hentunen TA, Laitinen S, Aro HT (2010) Circulating plastic adherent mesenchymal stem cells in aged hip fracture patients. J Orthop Res 28:1634–1642

    Article  PubMed  CAS  Google Scholar 

  • Barti-Juhasz H, Mihalik R, Nagy K, Grisendi G, Dominici M, Petak I (2011) Bone marrow derived mesenchymal stem/stromal cells transduced with full length human TRAIL repress the growth of rhabdomyosarcoma cells in vitro. Haematologica 96:e21–e22

    Article  PubMed  Google Scholar 

  • Bexell D, Scheding S, Bengzon J (2010) Toward brain tumor gene therapy using multipotent mesenchymal stromal cell vectors. Mol Ther 18:1067–1075

    Article  PubMed  CAS  Google Scholar 

  • Bui KC, Senadheera D, Wang X, Hendrickson B, Friedlich P, Lutzko C (2010) Recovery of multipotent progenitors from the peripheral blood of patients requiring extracorporeal membrane oxygenation support. Am J Respir Crit Care Med 181:226–237

    Article  PubMed  Google Scholar 

  • Choi SA, Hwang SK, Wang KC, Cho BK, Phi JH, Lee JY, Jung HW, Lee DH, Kim SK (2011) Therapeutic efficacy and safety of TRAIL-producing human adipose tissue-derived mesenchymal stem cells against experimental brainstem glioma. Neuro Oncol 13:61–69

    Article  PubMed  CAS  Google Scholar 

  • Ciavarella S, Dominici M, Dammacco F, Silvestris F (2011) Mesenchymal stem cells: a new promise in anticancer therapy. Stem Cells Dev 20:1–10

    Article  PubMed  CAS  Google Scholar 

  • Compte M, Cuesta AM, Sánchez-Martín D, Alonso-Camino V, Vicario JL, Sanz L, Alvarez-Vallina L (2009) Tumor immunotherapy using gene-modified human mesenchymal stem cells loaded into synthetic extracellular matrix scaffolds. Stem Cells 27:753–760

    Article  PubMed  CAS  Google Scholar 

  • Corsten MF, Shah K (2008) Therapeutic stem-cells for cancer treatment: hopes and hurdles in tactical warfare. Lancet Oncol 9:376–384

    Article  PubMed  Google Scholar 

  • Dwyer RM, Potter-Beirne SM, Harrington KA, Lowery AJ, Hennessy E, Murphy JM, Barry FP, O’Brien T, Kerin MJ (2007) Monocyte chemotactic protein-1 secreted by primary breast tumors stimulates migration of mesenchymal stem cells. Clin Cancer Res 13:5020–5027

    Article  PubMed  CAS  Google Scholar 

  • Francois S, Bensidhoum M, Mouiseddine M, Mazurier C, Allenet B, Semont A, Frick J, Sache A, Bouchet S, Thierry D, Gourmelon P, Gorin NC, Chapel A (2006) Local irradiation not only induces homing of human mesenchymal stem cells at exposed sites but promotes their widespread engraftment to multiple organs: a study of their quantitative distribution after irradiation damage. Stem Cells 24:1020–1029

    Article  PubMed  Google Scholar 

  • Friedenstein AJ, Lalykina KS (1970) The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet 3:393–403

    PubMed  CAS  Google Scholar 

  • García-Castro J, Alemany R, Cascalló M, Martínez-Quintanilla J, Arriero Mdel M, Lassaletta A, Madero L, Ramírez M (2010) Treatment of metastatic neuroblastoma with systemic oncolytic virotherapy delivered by autologous mesenchymal stem cells: an exploratory study. Cancer Gene Ther 17:476–483

    Article  PubMed  Google Scholar 

  • García-Gómez I, Elvira G, Zapata AG, Lamana ML, Ramírez M, Castro JG, Arranz MG, Vicente A, Bueren J, García-Olmo D (2010) Mesenchymal stem cells: biological properties and clinical applications. Expert Opin Biol Ther 10:1453–1468

    Article  PubMed  Google Scholar 

  • Goldberg ED, Dygai AM, Zhdanov VV, Zyuzkov GN, Guryantseva LA, Pershina OV, Poveteva TN, Stavrova LA, Khrichkova TY (2006) Participation of mesenchymal precursor cells in wound healing on skin flap model. Bull Exp Biol Med 142:116–118

    Article  PubMed  CAS  Google Scholar 

  • Grisendi G, Bussolari R, Cafarelli L, Petak I, Rasini V, Veronesi E, De Santis G, Spano C, Tagliazzucchi M, Barti-Juhasz H, Scarabelli L, Bambi F, Frassoldati A, Rossi G, Casali C, Morandi U, Horwitz EM, Paolucci P, Conte P, Dominici M (2010) Adipose-derived mesenchymal stem cells as stable source of tumor necrosis factor-related apoptosis-inducing ligand delivery for cancer therapy. Cancer Res 70:3718–3729

    Article  PubMed  CAS  Google Scholar 

  • Gunnarsson S, Bexell D, Svensson A, Siesjö P, Darabi A, Bengzon J (2010) Intratumoral IL-7 delivery by mesenchymal stromal cells potentiates IFNgamma-transduced tumor cell immunotherapy of experimental glioma. J Neuroimmunol 218:140–144

    Article  PubMed  CAS  Google Scholar 

  • Heissig B, Rafii S, Akiyama H, Ohki Y, Sato Y, Rafael T, Zhu Z, Hicklin DJ, Okumura K, Ogawa H, Werb Z, Hattori K (2005) Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization. J Exp Med 202:739–750

    Article  PubMed  CAS  Google Scholar 

  • Ho IA, Chan KY, Ng WH, Guo CM, Hui KM, Cheang P, Lam PY (2009) Matrix metalloproteinase 1 is necessary for the migration of human bone marrow-derived mesenchymal stem cells toward human glioma. Stem Cells 27:1366–1375

    Article  PubMed  CAS  Google Scholar 

  • Houghton J, Stoicov C, Nomura S, Rogers AB, Carlson J, Li H, Cai X, Fox JG, Goldenring JR, Wang TC (2004) Gastric cancer originating from bone marrow-derived cells. Science 306:1568–1571

    Article  PubMed  CAS  Google Scholar 

  • Hung SC, Pochampally RR, Hsu SC, Sanchez C, Chen SC, Spees J, Prockop DJ (2007) Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo. PLoS One 2:e416

    Article  PubMed  Google Scholar 

  • Karp JM, Leng Teo GS (2009) Mesenchymal stem cell homing: the devil is in the details. Cell Stem Cell 4:206–216

    Article  PubMed  CAS  Google Scholar 

  • Klopp AH, Spaeth EL, Dembinski JL, Woodward WA, Munshi A, Meyn RE, Cox JD, Andreeff M, Marini FC (2007) Tumor irradiation increases the recruitment of circulating mesenchymal stem cells into the tumor microenvironment. Cancer Res 67:11687–11695

    Article  PubMed  CAS  Google Scholar 

  • Klopp AH, Gupta A, Spaeth E, Andreeff M, Marini F (2011) Concise review: dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth? Stem Cells 29:11–19

    Article  PubMed  CAS  Google Scholar 

  • Komarova S, Kawakami Y, Stoff-Khalili MA, Curiel DT, Pereboeva L (2006) Mesenchymal progenitor cells as cellular vehicles for delivery of oncolytic adenoviruses. Mol Cancer Ther 5:755–766

    Article  PubMed  CAS  Google Scholar 

  • Kosztowski T, Zaidi HA, Quinones-Hinojosa A (2009) Applications of neural and mesenchymal stem cells in the treatment of gliomas. Expert Rev Anticancer Ther 9:597–612

    Article  PubMed  CAS  Google Scholar 

  • Laconi E (2007) The evolving concept of tumor microenvironments. Bioessays 29:738–744

    Article  PubMed  CAS  Google Scholar 

  • Li Y, Yu X, Lin S, Li X, Zhang S, Song YH (2007) Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells. Biochem Biophys Res Commun 356:780–784

    Article  PubMed  CAS  Google Scholar 

  • Nakamizo A, Marini F, Amano T, Khan A, Studeny M, Gumin J, Chen J, Hentschel S, Vecil G, Dembinski J, Andreeff M, Lang FF (2005) Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res 65:3307–3318

    PubMed  CAS  Google Scholar 

  • Nakamura K, Ito Y, Kawano Y, Kurozumi K, Kobune M, Tsuda H, Bizen A, Honmou O, Niitsu Y, Hamada H (2004) Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model. Gene Ther 11:1155–1164

    Article  PubMed  CAS  Google Scholar 

  • Ponte AL, Marais E, Gallay N, Langonné A, Delorme B, Hérault O, Charbord P, Domenech J (2007) The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Stem Cells 25:1737–1745

    Article  PubMed  CAS  Google Scholar 

  • Ramírez M, Lucia A, Gómez-Gallego F, Esteve-Lanao J, Pérez-Martínez A, Foster C, Andreu AL, Martin MA, Madero L, Arenas J, García-Castro J (2006) Mobilisation of mesenchymal cells into blood in response to skeletal muscle injury. Br J Sports Med 40:719–722

    Article  PubMed  Google Scholar 

  • Roth JC, Curiel DT, Pereboeva L (2008) Cell vehicle targeting strategies. Gene Ther 15:716–729

    Article  PubMed  CAS  Google Scholar 

  • Ryu CH, Park SH, Park SA, Kim SM, Lim JY, Jeong CH, Yoon WS, Oh WI, Sung YC, Jeun SS (2011) Gene therapy of intracranial glioma using interleukin 12-secreting human umbilical cord blood-derived mesenchymal stem cells. Hum Gene Ther 22:733–743

    Article  PubMed  CAS  Google Scholar 

  • Schichor C, Birnbaum T, Etminan N, Schnell O, Grau S, Miebach S, Aboody K, Padovan C, Straube A, Tonn JC, Goldbrunner R (2006) Vascular endothelial growth factor A contributes to glioma-induced migration of human marrow stromal cells (hMSC). Exp Neurol 199:301–310

    Article  PubMed  CAS  Google Scholar 

  • Schmidt A, Ladage D, Schinkothe T, Klausmann U, Ulrichs C, Klinz FJ, Brixius K, Arnhold S, Desai B, Mehlhorn U, Schwinger RH, Staib P, Addicks K, Bloch W (2006) Basic fibroblast growth factor controls migration in human mesenchymal stem cells. Stem Cells 24:1750–1758

    Article  PubMed  CAS  Google Scholar 

  • Seo SH, Kim KS, Park SH, Suh YS, Kim SJ, Jeun SS, Sung YC (2011) The effects of mesenchymal stem cells injected via different routes on modified IL-12-mediated antitumor activity. Gene Ther 18:488–495

    Article  PubMed  CAS  Google Scholar 

  • Spaeth E, Klopp A, Dembinski J, Andreeff M, Marini F (2008) Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells. Gene Ther 15:730–738

    Article  PubMed  CAS  Google Scholar 

  • Studeny M, Marini FC, Champlin RE, Zompetta C, Fidler IJ, Andreeff M (2002) Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors. Cancer Res 62:3603–3608

    PubMed  CAS  Google Scholar 

  • Tomchuck SL, Zwezdaryk KJ, Coffelt SB, Waterman RS, Danka ES, Scandurro AB (2007) Toll-like receptors on human mesenchymal stem cells drive their migration and immunomodulating responses. Stem Cells 26:99–107

    Article  PubMed  Google Scholar 

  • Wang H, Cao F, De A, Cao Y, Contag C, Gambhir SS, Wu JC, Chen X (2009) Trafficking mesenchymal stem cell engraftment and differentiation in tumor-bearing mice by bioluminescence imaging. Stem Cells 27:1548–1558

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Oncohematología y Trasplante, Hospital Universitario Niño Jesús, Avenida Menéndez Pelayo, 65, 28009, Madrid, Spain

    Manuel Ramírez & Javier García Castro

Authors
  1. Manuel Ramírez
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Javier García Castro
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Manuel Ramírez .

Editor information

Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media B.V.

About this chapter

Cite this chapter

Ramírez, M., Castro, J.G. (2012). Mesenchymal Stem Cells for the Treatment of Cancer. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 6. Stem Cells and Cancer Stem Cells, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2993-3_15

Download citation

Publish with us

Policies and ethics

Search

Navigation