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Stem Cells and Human Diseases pp 323–351Cite as

Worth the Weight: Adipose Stem Cells in Human Disease

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Abstract

Adipose Stem Cells (ASCs) are at the forefront of reconstructive and regenerative medicine, currently offering perhaps the most significant utilization of stem cells in the treatment of injured and dysfunctional connective or mesenchymal tissue; be it in bone, cartilage, fat, muscle, or heart tissues. However, these cells are also at the heart of adipogenesis and adipose endocrine function, playing key roles in numerous diseases and disorders relating to obesity, lipidystrophies, diabetes, and metabolic dysfunction. Adipose is an extremely heterogeneous tissue, with research indicating that cross-talk between numerous cells types creates a dynamic niche where cell populations are continually shifting to direct endogenous stem/progenitor cell activity. The study of these dynamics may elucidate additional aspects of stem cell influence over adipose health and dysfunction, as well as other mechanisms of cross-talk and cell differentiation which are mirrored in major ­tissues such as the liver, heart, and brain, thus allowing for new sources of adult stem/progenitor cells.

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Authors and Affiliations

  1. Department of Obstetrics/Gynecology, Medical College of Georgia at Georgia Health Sciences University, Augusta, GA, USA

    Saleh Heneidi

  2. Department of Obstetrics/Gynecology, The David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, 951740, Los Angeles, CA, 90095-1740, USA

    Gregorio Chazenbalk Ph.D.

Authors
  1. Saleh Heneidi
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  2. Gregorio Chazenbalk Ph.D.
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Correspondence to Gregorio Chazenbalk Ph.D. .

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Editors and Affiliations

  1. , Pharmacology and Toxicology, University of Kansas Medical Center, Rainbow Blvd 3901, Kansas City, 66160, Kansas, USA

    Rakesh Srivastava

  2. , Pathology and Laboratory Medicine, University of Kansas Medical Center, Rainbow Blvd 3901, Kansas City, 66160, Kansas, USA

    Sharmila Shankar

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© 2012 Springer Science+Business Media B.V.

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Heneidi, S., Chazenbalk, G. (2012). Worth the Weight: Adipose Stem Cells in Human Disease. In: Srivastava, R., Shankar, S. (eds) Stem Cells and Human Diseases. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2801-1_15

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