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Fertility Preservation Options for Females

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Reproductive Health and Cancer in Adolescents and Young Adults

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 732))

Abstract

Oncofertility is an interdisciplinary field in which providers of oncology and reproductive health care provide patients with options for fertility after cancer treatment. Infertility following cancer treatment occurs for various reasons including the need for removal of reproductive organs as well as the effects of chemotherapy and radiation on gametes and reproductive hormones. Unfortunately, few patients have comprehensive counseling on fertility preservation options prior to undergoing treatment (Schover et al., Cancer 86(4):697–709, 1999). This chapter explains the options for maintenance of fertility including oophoropexy/ovarian transposition, conservative surgical and medical management of gynecologic cancers, embryo cryopreservation via in vitro fertilization, oocyte cryopreservation, use of donor oocytes and donor embryos, gestational surrogacy, ovarian cortex cryopreservation and transplantation, in vitro maturation, ovarian suppression, uterine transplantation, and the potential for generation of gametes from somatic cells.

My health care team had everything coordinated for me like I was royalty. I had the breast cancer surgery in early March, and two weeks later I was starting my treatment for egg retrieval. I started my chemotherapy, as planned, the next month. I thought doing the egg retrieval right after I finished surgery was going to be too intense, but I was so happy to be doing something that was going to take me one step closer to having the baby I always dreamed of. During the dark days of chemo, I often thought about my frozen eggs and how better things lay ahead for me. I am so thankful that I was in a place that knew how to coordinate all this for me. I read horror stories on line about women who weren’t told about infertility or weren’t given options or were told it would delay their treatment and there wasn’t time. I can’t say I’m glad I got cancer, but I am elated with the coordination I had for all aspects of my care.

Courtney, Adult Cancer Patient

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Abbreviations

AMH:

anti-Mullerian hormone

ART:

assisted reproductive technologies

ASRM:

American Society for Reproductive Medicine

cGy:

centigray

FSH:

follicle stimulating hormone

GnRH:

gonadotropin-releasing hormone

Gy:

Gray

hCG:

human chorionic gonadotropin

IVF:

in vitro fertilization

IVM:

in vitro maturation

OHSS:

ovarian hyperstimulation syndrome

PGD:

preimplantation genetic diagnosis

SART:

The Society for Assisted Reproductive Technologies

References

  1. Surveillance Epidemiology and End Results Cancer Statistics http://seer.cancer.gov. Accessed 2 May 2011

  2. Carter J, Sonoda Y, Abu-Rustum N (2007) Reproductive concerns of women treated with radical trachelectomy for cervical cancer. Gynecol Oncol 105:13–16

    PubMed  Google Scholar 

  3. Noyes N, Reh A, Mullin C, Fino ME, Grifo J (2010) Quality-of-life (QOL) assessment at time of fertility preservation (FP) counseling in female cancer patients: results of a university-based registry at two years. J Clin Oncol 28(Supp 15):e1964

    Google Scholar 

  4. Lee SJ, Schover LR, Partridge AH, Patrizio P, Wallace WH, Hagerty K, Beck LN, Brennan LV, Oktay K (2006) American Society of Clinical Oncology Recommendations on Fertility Preservation in Cancer Patients. J Clin Oncol 24(18):2917–2931

    PubMed  Google Scholar 

  5. Nakayama K, Ueno NT (2006) American Society of Clinical Oncology recommendations on fertility preservation should be implemented regardless of disease status or previous treatments. J Clin Oncol 24(33):5334–5335

    PubMed  Google Scholar 

  6. Anchan RM, Ginsburg ES (2010) Fertility concerns and preservation in younger women with breast cancer. Crit Rev Oncol Hematol 74:175–192

    PubMed  Google Scholar 

  7. Ethics Committee of the American Society for Reproductive Medicine (2005) Fertility preservation and reproduction in cancer patients. Fertil Steril 83:1622–1628

    Google Scholar 

  8. Seifer D, Lambert-Messerlian G, Hogan J, Gardiner A, Blazar A, Berk C (1997) Day 3 serum inhibin-B is predictive of assisted reproductive technologies outcome. Fertil Steril 67:110–114

    PubMed  CAS  Google Scholar 

  9. te Velde ER, Pearson PL (2002) The variability of female reproductive ageing. Hum Reprod Update 8:141–154

    Google Scholar 

  10. Noyes N, Knopman J, Long K, Coletta JM, Abu-Rustum NR (2011) Fertility considerations in the management of gynecologic malignancies. Gynecol Oncol 120:326–333

    PubMed  Google Scholar 

  11. Ng E, Yeung W, Fong D, Ho P (2003) Effects of age on hormonal and ultrasound markers of ovarian reserve in Chinese women with proven fertility. Hum Reprod 18:2169–2174

    PubMed  Google Scholar 

  12. Syrop C, Dawson J, Husman K, Sparks A, Van Voorhis B (1999) Ovarian volume may predict assisted reproductive outcomes better than follicle stimulating hormone concentration on day 3. Hum Reprod 14:1752–1756

    PubMed  CAS  Google Scholar 

  13. Chui D, Pugh N, Walker S, Gregory L, Shaw R (1997) Follicular vascularity – the predictive value of transvaginal power Doppler ultrasonography in an in-vitro fertilization programme: a preliminary study. Hum Reprod 12:191–196

    PubMed  CAS  Google Scholar 

  14. WomensHealth.gov: The Federal Government Source for Women’s Health Information http://www.womenshealth.gov/menopause/basics. Accessed 8 June 2011

  15. Noyes N, Hampton BS, Berkeley A, Licciardi F, Grifo J, Krey L (2001) Factors useful in predicting success for oocyte donation cycles: a three-year retrospective analysis. Fertil Steril 76:92–97

    PubMed  CAS  Google Scholar 

  16. Pendse S, Ginsburg E, Singh AK (2004) Strategies for preservation of ovarian and testicular function after immunosuppression. Am J Kidney Dis 43(5):772–781

    PubMed  Google Scholar 

  17. Blumenfeld Z, Avivi I, Ritter M, Rowe JM (1999) Preservation of fertility and ovarian function and minimizing chemotherapy-induced gonadotoxicity in young women. J Soc Gynecol Investig 6(5):229–239

    PubMed  CAS  Google Scholar 

  18. Rosendahl M, Andersen CY, la Cour Freiesleben N, Juul A, Lossl K, Andersen AN (2010) Dynamics and mechanisms of chemotherapy-induced ovarian follicular depletion in women of fertile age. Fertil Steril 94(1):156–166

    PubMed  CAS  Google Scholar 

  19. Ginsburg ES, Yanushpolsky EH, Jackson KV (2001) In vitro fertilization for cancer patients and survivors. Fertil Steril 75(4):705–710

    PubMed  CAS  Google Scholar 

  20. Hodgson DC, Pintilie M, Gitterman L, Dewitt B, Buckley CA, Ahmed S, Smith K, Schwartz A, Tsang RW, Crump M, Wells W, Sun A, Gospodarowicz MK (2007) Fertility among female hodgkin lymphoma survivors attempting pregnancy following ABVD chemotherapy. Hematol Oncol 25(1):11–15

    PubMed  Google Scholar 

  21. Partridge AH, Gelber S, Peppercorn J, Ginsburg E, Sampson E, Rosenberg R, Przypyszny M, Winer EP (2008) Fertility and menopausal outcomes in young breast cancer survivors. Clin Breast Cancer 8(1): 65–69

    PubMed  Google Scholar 

  22. Wallace WH, Thomson AB, Kelsey TW (2003) The radiosensitivity of the human oocyte. Hum Reprod 18:117–121

    PubMed  CAS  Google Scholar 

  23. Brannstrom M, Diaz-Garcia C (2011) Transplantation of female genital organs. J Obstet Gynaecol Res 37(4):271–291

    PubMed  Google Scholar 

  24. Meirow D (2000) Reproduction post-chemotherapy in young cancer patients. Mol Cell Endocrinol 169:123–131

    PubMed  CAS  Google Scholar 

  25. Oktem O, Urman B (2010) Options of fertility preservation in female cancer patients. Obstet Gynecol Surv 65(8):531–542

    PubMed  Google Scholar 

  26. Paris F, Perez GI, Fuks Z, Haimovitz-Friedman A, Nguyen H, Bose M, Ilagan A, Hunt PA, Morgan WF, Tilly JL, Kolesnick R (2002) Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. Nat Med 8(9):901–902

    PubMed  CAS  Google Scholar 

  27. Wallace WH, Thomson AB, Saran F, Kelsey TW (2005) Predicting age of ovarian failure after radiation to a field that includes the ovaries. Int J Radiat Oncol Biol Phys 62:738–744

    PubMed  Google Scholar 

  28. Wallace WH, Anderson RA, Irvine DS (2005) Fertility preservation for young patients with cancer: who is at risk and what can be offered? Lancet Oncol 6(4):209–218

    PubMed  Google Scholar 

  29. Hawkins MM, Smith RA (1989) Pregnancy outcomes in childhood cancer survivors: probable effects of abdominal irradiation. Int J Cancer 43:399–402

    PubMed  CAS  Google Scholar 

  30. Critchley HO, Wallace WH, Shalet SM, Mamtora H, Higginson J, Anderson DC (1992) Abdominal irradiation in childhood; the potential for pregnancy. Br J Obstet Gynaecol 99:392–394

    PubMed  CAS  Google Scholar 

  31. Meirow D, Nugent D (2001) The effects of radiotherapy on female reproduction. Hum Reprod Update 7:535–543

    PubMed  CAS  Google Scholar 

  32. Nussbaum Blask AR, Nicholson HS, Markle BM, Wechsler-Jentzch K, O’Donnell R, Byrne J (1999) Sonographic detection of uterine and ovarian abnormalities in female survivors of Wilms’ tumor treated with radiotherapy. Am J Roentgenol 172:759–763

    CAS  Google Scholar 

  33. Critchley HO, Bath LE, Wallace WH (2002) Radiation damage to the uterus—review of the effects of treatment of childhood cancer. Hum Fertil 5:61–66

    Google Scholar 

  34. Andersen BL, Green DM (2001) Fertility and Sexuality after Cancer Treatment. In: Lenhard RE Jr, Osteen RT, Gansler T (eds) Clinical oncology. American Cancer Society, Atlanta, Georgia

    Google Scholar 

  35. Li FP, Fine W, Jaffe N, Holmes GE, Holmes FF (1979) Offspring of patients treated for cancer in childhood. J Natl Cancer Inst 62:1193–1197

    PubMed  CAS  Google Scholar 

  36. Hawkins MM, Smith RA, Curtice LJ (1988) Childhood cancer survivors and their offspring studied through a postal survey of general practitioners: preliminary results. J R Coll Gen Pract 38:102–105

    PubMed  CAS  Google Scholar 

  37. Byrne J, Rasmussen SA, Steinhorn SC, Connelly RR, Myers MH, Lynch CF, Flannery J, Austin DF, Holmes FF, Holmes GE, Strong LC, Mulvihill JJ (1998) Genetic disease in offspring of long-term survivors of childhood and adolescent cancer. Am J Hum Genet 62(1):45–52

    PubMed  CAS  Google Scholar 

  38. Gershenson DM (2005) Fertility-sparing surgery for malignancies in women. J Natl Cancer Inst Monogr 34:43–47

    PubMed  Google Scholar 

  39. Elizur SE, Tulandi T, Meterissian S, Huang JY, Levin D, Tan SL (2009) Fertility preservation for young women with rectal cancer – a combined approach from one referral center. J Gastrointest Surg 13:1111–1115

    PubMed  Google Scholar 

  40. Williams RS, Littell RD, Mendenhall NP (1999) Laparoscopic oophoropexy and ovarian function in the treatment of Hodgkin disease. Cancer 86(10):2138–2142

    PubMed  CAS  Google Scholar 

  41. Husseinzadeh N, Nahhas WA, Velkley DE, Whitney CW, Mortel R (1984) The preservation of ovarian function in young women undergoing pelvic radiation therapy. Gynecol Oncol 18(3):373–379

    PubMed  CAS  Google Scholar 

  42. Terenziani M, Piva L, Meazza C, Gandola L, Cefalo G, Merola M (2009) Oophoropexy: a relevant role in preservation of ovarian function after pelvic irradiation. Fertil Steril 91(3):935, e15–16

    PubMed  Google Scholar 

  43. Jenninga E, Hilders CG, Louwe LA, Peters AA (2008) Female fertility preservation: practical and ethical considerations of an underused procedure. Cancer 14(5):333–339

    Google Scholar 

  44. Clough KB, Goffinet F, Labib A, Renolleau C, Campana F, de la Rochefordiere A, Durand JC (1996) Laparoscopic unilateral ovarian transposition prior to irradiation: Prospective study of 20 cases. Cancer 77:2638–2645

    PubMed  CAS  Google Scholar 

  45. Damewood MD, Hesla HS, Lowen M, Schultz MJ (1990) Induction of ovulation and pregnancy following lateral oophoropexy for Hodgkin’s disease. Int J Gynaecol Obstet 33:369–371

    PubMed  CAS  Google Scholar 

  46. Zinger M, Liu JH, Husseinzadeh N, Thomas MA (2004) Successful surrogate pregnancy after ovarian transposition, pelvic irradiation and hysterectomy. J Reprod Med 49:573–574

    PubMed  Google Scholar 

  47. Blumenfeld Z (2001) Ovarian rescue/protection from chemotherapeutic agents. J Soc Gynecol Invest 8:S60–S64

    CAS  Google Scholar 

  48. Buekers TE, Anderson B, Sorosky JI, Buller RE (2001) Ovarian function after surgical treatment for cervical cancer. Gynecol Oncol 80:85–88

    PubMed  CAS  Google Scholar 

  49. Pfeifer S, Coutifaris C (1999) Reproductive technologies 1998: options available for the cancer patient. Med Pediatr Oncol 33:34–40

    PubMed  CAS  Google Scholar 

  50. Morice P, Thiam-Ba R, Castaigne D, Haie-Meder C, Gerbaulet A, Pautier P, Duvillard P, Michel G (1998) Fertility results after ovarian transposition for pelvic malignancies treated by external irradiation or brachytherapy. Hum Reprod 13:660–663

    PubMed  CAS  Google Scholar 

  51. Barton SE, Politch JA, Benson CB, Ginsburg ES, Gargiulo AR (2011) Transabdominal follicular aspiration for oocyte retrieval in patients with ovaries inaccessible by transvaginal ultrasound. Fertil Steril 95(5):1773–1776

    PubMed  Google Scholar 

  52. Simon B, Lee SJ, Partridge AH, Runowicz CD (2005) Preserving fertility after cancer. CA Cancer J Clin 55:211–228

    PubMed  Google Scholar 

  53. Gershenson DM (1988) Menstrual and reproductive function after treatment with combination chemotherapy for malignant ovarian germ cell tumors. J Clin Oncol 6:270–275

    PubMed  CAS  Google Scholar 

  54. Zanetta G, Bonazzi C, Cantu MG, Bini S, Locatelli A, Bratina G, Mangioni C (2001) Survival and reproductive function after treatment of malignant germ cell ovarian tumors. J Clin Oncol 19:1015–1020

    PubMed  CAS  Google Scholar 

  55. Lim-Tam S, Cajigas HE, Scully RE (1988) Ovarian cystectomy for serous borderline tumors: a follow-up study of 35 cases. Obstet Gynecol 72:775–781

    Google Scholar 

  56. Zanetta G, Rota S, Chiari S, Bonazzi C, Bratina G, Mangioni C (2001) Behavior of borderline tumors with particular interest to persistence, recurrence, and progression to invasive carcinoma: a prospective study. J Clin Oncol 19:2658–2664

    PubMed  CAS  Google Scholar 

  57. Schilder JM, Thompson AM, DePriest PD, Ueland FR, Cibull ML, Kryscio RJ, Modesitt SC, Lu KH, Geisler JP, Higgins RV, Magtibay PM, Cohn DE, Powell MA, Chu C, Stehman FB, van Nagell J (2002) Outcome of reproductive age women with stage IA or IC invasive epithelial ovarian cancer treated with fertility-sparing therapy. Gynecol Oncol 87:1–7

    PubMed  Google Scholar 

  58. Seracchioli R, Venturoli S, Colombo FM, Govoni F, Missiroli S, Bagnoli A (2001) Fertility and tumor recurrence rate after conservative laparoscopic management of young women with early-stage borderline ovarian tumors. Fertil Steril 76:999–1003

    PubMed  CAS  Google Scholar 

  59. Ungar L, Palfalvi L, Hogg R, Sikos P, Boyle DC, Del Priore G, Smith JR (2005) Abdominal radical trachelectomy: A fertility-preserving option for women with early cervical cancer. BJOG 112:366–369

    PubMed  Google Scholar 

  60. Dargent D, Martin X, Sacchetoni A, Mathevet P (2000) Laparoscopic vaginal radical trachelectomy: A treatment to preserve the fertility of cervical carcinoma patients. Cancer 88:1877–1882

    PubMed  CAS  Google Scholar 

  61. Plante M, Renaud MC, Francois H, Roy M (2004) Vaginal radical trachelectomy: An oncologically safe fertility-preserving surgery. An updated series of 72 cases and review of the literature. Gynecol Oncol 94:614–623

    Google Scholar 

  62. Plante M, Renaud MC, Hoskins IA, Roy M (2005) Vaginal radical trachelectomy: a valuable fertility-preserving option in the management of early-stage cervical cancer. A series of 50 pregnancies and review of the literature. Gynecol Oncol 98:3–10

    Google Scholar 

  63. Plante M (2003) Fertility preservation in the management of cervical cancer. CME J Gynecol Oncol 8:97–107

    Google Scholar 

  64. Koliopoulos G, Sotiriadis A, Kyrgiou M, Martin-Hirsch P, Makrydimas G, Paraskevaidis E (2004) Conservative surgical methods for FIGO stage IA2 squamous cervical carcinoma and their role in preserving women’s fertility. Gynecol Oncol 93:469–473

    PubMed  Google Scholar 

  65. Shepherd JH, Mould T, Oram DH (2001) Radical trachelectomy in early stage carcinoma of the cervix: Outcome as judged by recurrence and fertility rates. BJOG 108:882–885

    PubMed  CAS  Google Scholar 

  66. Dargent D (2001) Radical trachelectomy: an operation that preserves the fertility of young women with invasive cervical cancer. Bull Acad Natl Med 185:1295–1304

    PubMed  CAS  Google Scholar 

  67. Burnett AF, Roman LD, O’Meara AT, Morrow CP (2003) Radical vaginal trachelectomy and pelvic lymphadenectomy for preservation of fertility in early cervical carcinoma. Gynecol Oncol 88:419–423

    PubMed  Google Scholar 

  68. Roy M, Plante M (1998) Pregnancies after radical vaginal trachelectomy for early-stage cervical cancer. Am J Obstet Gynecol 179:1491–1496

    PubMed  CAS  Google Scholar 

  69. Bernardini M, Barrett J, Seaward G, Covens A (2003) Pregnancy outcomes in patients with radical trachelectomy. Am J Obstet Gynecol 189:1378–1382

    PubMed  Google Scholar 

  70. Covens A, Shaw P, Murphy J, DePetrillo D, Lickrish G, Laframboise S, Rosen B (1999) Is radical trachelectomy a safe alternative to radical hysterectomy for patients with stage IA-B carcinoma of the cervix? Cancer 86:2273–2279

    PubMed  CAS  Google Scholar 

  71. Erkanli S, Ayhan A (2010) Fertility-sparing therapy in young women with endometrial cancer: 2010 update. Int J Gynecol Cancer 20(7):1170–1187

    PubMed  Google Scholar 

  72. Masciullo V, Amadio G, Lo Russo D, Raimondo I, Giordano A, Scambia G (2010) Controversies in the management of endometrial cancer. Obstet Gynecol Int 2010:638165

    PubMed  CAS  Google Scholar 

  73. Society for Assisted Reproductive Technology http://www.sart.org. Accessed 6 May 2011

  74. Robertson AD, Missmer SA, Ginsburg ES (2011) Embryo yield after in vitro fertilization in women undergoing embryo banking for fertility preservation before chemotherapy. Fertil Steril 95(2):588–591

    PubMed  Google Scholar 

  75. Schover LR, Rybicki LA, Martin BA, Bringelsen KA (1999) Having children after cancer: A pilot survey of survivors’ attitudes and experiences. Cancer 86(4):697–709

    PubMed  CAS  Google Scholar 

  76. Baynosa J, Westphal L, Madrigrano A, Wapnir I (2009) Timing of breast cancer treatments with oocyte retrieval and embryo cryopreservation. J Am Coll Surg 209:603–607

    PubMed  Google Scholar 

  77. Noyes N, Labella P, Grifo J, Knopman JM (2010) Oocyte cryopreservation: a feasible fertility preservation option for reproductive age cancer survivors. J Assist Reprod Genet 27:495–499

    PubMed  Google Scholar 

  78. Kim SS, Klemp J, Fabian C (2011) Breast cancer and fertility preservation. Fertil Steril 95(5):1535–1541

    PubMed  Google Scholar 

  79. Maman E, Meirow D, Brengauz M, Raanani H, Dor J, Hourvitz A (2011) Luteal phase oocyte retrieval and in vitro maturation is an optional procedure for urgent fertility preservation. Fertil Steril 95(1):64–67

    PubMed  Google Scholar 

  80. Oktay K, Buyuk E, Libertella N, Akar M, Rosenwaks Z (2005) Fertility preservation in breast cancer patients: A prospective controlled comparison of ovarian stimulation with tamoxifen and letrozole for embryo cryopreservation. J Clin Oncol 23(19):4347–4353

    PubMed  CAS  Google Scholar 

  81. Engmann L, DiLuigi A, Schmidt D, Nulsen J, Maier D, Benadiva C (2008) The use of gonadotropin-releasing hormone agonist to induce oocyte maturation after cotreatment with GnRH antagonist in high-risk patients undergoing in vitro fertilization prevents the risk of ovarian hyperstimulation syndrome: a prospective randomized controlled study. Fertil Steril 89(1):84–91

    PubMed  CAS  Google Scholar 

  82. Whittemore AS, Harris R, Itnyre J for the Collaborative Ovarian Cancer Group (1992) Characteristics relating to ovarian cancer risk: collaborative analysis of 12 U.S. case-control studies. II. Invasive epithelial ovarian cancers in white women. Am J Epidemiol 136:1184–1203

    PubMed  CAS  Google Scholar 

  83. Rossing MA, Daling JR, Weiss NS, Moore DE, Self SG (1994) Ovarian tumors in a cohort of infertile women. New Engl J Med 331:771–776

    PubMed  CAS  Google Scholar 

  84. Brinton LA, Lamb EJ, Moghissi KS, Scoccia B, Althuis MD, Mabie JE, Westhoff CL (2004) Ovarian cancer risk after the use of ovulation-stimulating drugs. Obstet Gynecol 103:1194–1203

    PubMed  Google Scholar 

  85. Oktay K (2005) Further evidence on the safety and success of ovarian stimulation with letrozole and tamoxifen in breast cancer patients undergoing in vitro fertilization to cryopreserve their embryos for fertility preservation. J Clin Oncol 23:3858–3859

    PubMed  Google Scholar 

  86. Oktay K, Hourvitz A, Sahin G, Oktem O, Safro B, Cil A, Bang H (2006) Letrozole reduces estrogen and gonadotropin exposure in women with breast cancer undergoing ovarian stimulation before chemotherapy. J Clin Endocrinol Metab 91:3885–3890

    PubMed  CAS  Google Scholar 

  87. Azim AA, Costantini-Ferrando M, Oktay K (2008) Safety of fertility preservation by ovarian stimulation with letrozole and gonadotropins in patients with breast cancer: a prospective controlled study. J Clin Oncol 26:2630–2635

    PubMed  CAS  Google Scholar 

  88. Kondapalli L, Hong F, Gracia C (2010) Clinical cases in oncofertility. Cancer Treat Res 156:55–67

    PubMed  Google Scholar 

  89. von Wolff M, Strowitzki T, van der Ven H, Montag M (2006) In vitro maturation is an efficient technique to generate oocytes and should be considered in combination with cryopreservation of ovarian tissue for preservation of fertility in women. J Clin Oncol 24(33):5336–5337

    Google Scholar 

  90. Smitz JE, Thompson JG, Gilchrist RB (2011) The promise of in vitro maturation in assisted reproduction and fertility preservation. Semin Reprod Med 29(1):24–37

    PubMed  CAS  Google Scholar 

  91. Mosgaard BJ, Lidegaard O, Kjaer SK, Schou G, Andersen AN (1997) Infertility, fertility drugs and invasive ovarian cancer: a case-control study. Fertil Steril 67:1005–1012

    PubMed  CAS  Google Scholar 

  92. Rossing MA, Daling JR, Weiss NS, Moore DE, Self SG (1996) Risk of breast cancer in a cohort in infertile women. Gynecol Oncol 60:3–7

    PubMed  CAS  Google Scholar 

  93. Hawkins MM (1994) Pregnancy outcome and offspring after childhood cancer. BMJ 309:1034

    PubMed  CAS  Google Scholar 

  94. Thomson AB, Campbell AJ, Irvine DC, Anderson RA, Kelnar CJ, Wallace WH (2002) Semen quality and spermatozoal DNA integrity in survivors of childhood cancer: a case-control study. Lancet 360:361–367

    PubMed  CAS  Google Scholar 

  95. Green DM, Whitton JA, Stovall M, Mertens AC, Donaldson SS, Ruymann FB, Pendergrass TW, Robison LL (2002) Pregnancy outcome of female survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Am J Obstet Gynecol 187:1070–1080

    PubMed  Google Scholar 

  96. Sankila R, Olsen JH, Anderson H, Garwicz S, Glattre E, Hertz H, Langmark F, Lanning M, Moller T, Tulinius H (1998) Risk of cancer among offspring of childhood-cancer survivors. Association of the Nordic Cancer Registries and the Nordic Society of Paediatric Haematology. New Engl J Med 338:1339–1344

    PubMed  CAS  Google Scholar 

  97. Green DM, Whitton JA, Stovall M, Mertens AC, Donaldson SS, Ruymann FB, Pendergrass TW, Robison LL (2003) Pregnancy outcome of partners of male survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Clin Oncol 21:716–721

    PubMed  Google Scholar 

  98. Stovall M, Donaldson SS, Weathers RE, Robison LL, Mertens AC, Winther JF, Olsen JH, Boice JD Jr (2004) Genetic effects of radiotherapy for childhood cancer: gonadal dose reconstruction. Int J Radiat Oncol Biol Phys 60:542–552

    PubMed  Google Scholar 

  99. Boice JD Jr, Tawn EJ, Winther JF, Donaldson SS, Green DM, Mertens AC, Mulvihill JJ, Olsen JH, Robison LL, Stovall M (2003) Genetic effects of radiotherapy for childhood cancer. Health Phys 85:65–80

    PubMed  CAS  Google Scholar 

  100. Yang D, Brown SE, Nguyen K, Reddy V, Brubaker C, Winslow KL (2007) Live birth after the transfer of human embryos developed from cryopreserved oocytes harvested before cancer treatment. Fertil Steril 87(6):1469, e1–4

    PubMed  Google Scholar 

  101. Yoon TK, Kim TJ, Park SE, Hong SW, Ko JJ, Chung HM, Cha KY (2003) Live births after vitrification of oocytes in a stimulated in vitro fertilization embryo transfer program. Fertil Steril 79(6):1323–1326

    PubMed  Google Scholar 

  102. Fabbri R, Porcu E, Marsella T, Rocchetta G, Venturoli S, Flamigni C (2001) Human oocyte cryopreservation: new perspectives regarding oocyte survival. Hum Reprod 16(3):411–416

    PubMed  CAS  Google Scholar 

  103. Borini A, Sciajno R, Bianchi V, Sereni E, Flamigni C, Coticchio G (2006) Clinical outcome of oocyte cryopreservation after slow cooling with a protocol utilizing a high sucrose concentration. Hum Reprod 21(2):512–517

    PubMed  CAS  Google Scholar 

  104. Rudick B, Opper N, Paulson R, Bendikson K, Chung K (2010) The status of oocyte cryopreservation in the United States. Fertil Steril 94(7):2642–2646

    PubMed  Google Scholar 

  105. Oktay K, Cil AP, Bang H (2006) Efficiency of oocyte cryopreservation: a meta-analysis. Fertil Steril 86(1):70–80

    PubMed  Google Scholar 

  106. Noyes N, Porcu E, Borini A (2009) With more than 900 babies born, live birth outcomes following oocyte cryopreservation do not appear different from those occurring after conventional IVF. Reprod Biomed Online 18:769–776

    PubMed  CAS  Google Scholar 

  107. ASRM Practice Committee (2009) ASRM Practice Committee response to Rybak and Lieman: elective self-donation of oocytes. Fertil Steril 92:1513–1514

    Google Scholar 

  108. Galbraith M, McLachlan HV, Swales JK (2005) Commercial agencies and surrogate motherhood: a transaction cost approach. Health Care Anal 13(1):11–31

    PubMed  Google Scholar 

  109. Oktay K, Karlikaya G (2000) Ovarian function after transplantation of frozen, banked autologous ovarian tissue. New Engl J Med 342:1919

    PubMed  CAS  Google Scholar 

  110. Donnez J, Dolman MM, Demylle D, Jadoul P, Pirard C, Squifflet J, Martinez-Madrid B, van Langendonckt A (2004) Live birth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet 364:1405–1410

    PubMed  CAS  Google Scholar 

  111. Meirow D, Levron J, Eldar-Geva T, Hardan I, Fridman E, Zalel Y, Schiff E, Dor J (2005) Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy. New Engl J Med 353:318–321

    PubMed  CAS  Google Scholar 

  112. Radford JA, Lieberman BA, Brison DR, Smith AR, Critchlow JD, Russell SA, Watson AJ, Clayton JA, Harris M, Gosden RG, Shalet SM (2001) Orthotopic reimplantation of cryopreserved ovarian cortical strips after high-dose chemotherapy for Hodgkin’s lymphoma. Lancet 357:1172–1175

    PubMed  CAS  Google Scholar 

  113. Tryde Schmidt KL, Yding Andersen C, Starup J, Loft A, Byskov AG, Nyboe Andersen A (2004) Orthotopic autotransplantation of cryopreserved ovarian tissue to a woman cured of cancer-follicular growth, steroid production and oocyte retrieval. Reprod Biomed Online 8:448–453

    PubMed  Google Scholar 

  114. Oktay K, Buyuk E, Rosenwaks Z, Rucinski J (2003) A technique for transplantation of ovarian cortical strips to the forearm. Fertil Steril 80:193–198

    PubMed  Google Scholar 

  115. Oktay K, Economos K, Kan M, Rucinski J, Veeck L, Rosenwaks Z (2001) Endocrine function and oocyte retrieval after autologous transplantation of ovarian cortical strips to the forearm. JAMA 286(12):1490–1493

    PubMed  CAS  Google Scholar 

  116. Wallace WHB, Barr RD (2010) Fertility preservation for girls and young women with cancer: what are the remaining challenges? Hum Reprod Update 16(6):614–616

    PubMed  CAS  Google Scholar 

  117. Oktay K, Buyuk E, Veeck L, Zaninovic N, Xu K, Takeuchi T, Opsahl M, Rosenwaks Z (2004) Embryo development after heterotopic transplantation of cryopreserved ovarian tissue. Lancet 363:837–840

    PubMed  Google Scholar 

  118. Demeestere I, Simon P, Buxant F, Robin V, Fernandez SA, Centner J, Delbaere A, Englert Y (2006) Ovarian function and spontaneous pregnancy after combined heterotopic and orthotopic cryopreserved ovarian tissue transplantation in a patient previously treated with bone marrow transplantation: case report. Hum Reprod 21:2010–2014

    PubMed  Google Scholar 

  119. Andersen CY, Rosendahl M, Byskov AG, Loft A, Ottosen C, Dueholm M, Schmidt KL, Andersen AN, Ernst E (2008) Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue. Hum Reprod 23:2266–2272

    PubMed  Google Scholar 

  120. Silber SJ, DeRosa M, Pineda J, Lenahan K, Grenia D, Gorman K, Gosden RG (2008) A series of monozygotic twins discordant for ovarian failure: ovary transplantation (cortical vs. microvascular) and cryopreservation. Hum Reprod 23:1531–1537

    PubMed  CAS  Google Scholar 

  121. Donnez J, Squifflet J, Jadoul P, Demylle D, Cheron AC, van Langendonckt A, Dolman MM (2011) Pregnancy and live birth after autotransplantation of frozen-thawed ovarian tissue in a patient with metastatic disease undergoing chemotherapy and hematopoietic stem cell transplantation. Fertil Steril 95(5):1787

    PubMed  Google Scholar 

  122. Oktay K, Sonmezer M (2004) Ovarian tissue banking for cancer patients: fertility preservation, not just ovarian preservation. Hum Reprod 19(3):477–480

    PubMed  Google Scholar 

  123. Kim SS (2006) Fertility preservation in female cancer patients: current developments and future directions. Fertil Steril 85(1):1–11

    PubMed  CAS  Google Scholar 

  124. Meirow D, Fasouliotis SJ, Nugent D, Schenker JG, Gosden RG, Rutherford AJ (1999) A laparoscopic technique for obtaining ovarian cortical biopsy specimens for fertility conservation in patients with cancer. Fertil Steril 71:948–951

    PubMed  CAS  Google Scholar 

  125. Poirot C, Vacher-Lavenu MC, Helardot P, Guibert J, Brugieres L, Jouannet P (2002) Human ovarian tissue cryopreservation: indications and feasibility. Hum Reprod 17:1447–1452

    PubMed  Google Scholar 

  126. Newton H, Aubard Y, Rutherford A, Sharma V, Gosden R (1996) Low temperature storage and grafting of human ovarian tissue. Hum Reprod 11:1487–1491

    PubMed  CAS  Google Scholar 

  127. Dolmans MM, Marinescu C, Saussoy P, Van Langendonckt A, Amorim C, Donnez J (2010) Reimplantation of cryopreserved ovarian tissue from patients with acute lymphoblastic leukemia is potentially unsafe. Blood 116(16):2908–2914

    PubMed  CAS  Google Scholar 

  128. Oktay K (2009) Preservation of fertility in patients with cancer. New Engl J Med 360:2680–2683

    Google Scholar 

  129. Huober-Zeeb C, Lawrenz B, Popovici RM, Strowitzki T, Germeyer A, Stute P, von Wolff M (2011) Improving fertility preservation in cancer: ovarian tissue cryobanking followed by ovarian stimulation can be efficiently combined. Fertil Steril 95(1):342–344

    PubMed  Google Scholar 

  130. Blumenfeld Z, von Wolff M (2008) GnRH-analogues and oral contraceptives for fertility preservation in women during chemotherapy. Hum Reprod 14:543–552

    CAS  Google Scholar 

  131. Blumenfeld Z, Avivi I, Linn S, Epelbaum R, Ben-Shahar M, Haim N (1996) Prevention of irreversible chemotherapy-induced ovarian damage in young women with lymphoma by a gonadotrophin-releasing hormone agonist in parallel to chemotherapy. Hum Reprod 11:1620–1626

    PubMed  CAS  Google Scholar 

  132. Waxman JH, Ahmed R, Smith D, Wrigley PF, Gregory W, Shalet S, Crowther D, Rees LH, Besser GM, Malpas JS et al (1987) Failure to preserve fertility in patients with Hodgkin’s disease. Cancer Chemother Pharmacol 19:159–162

    PubMed  CAS  Google Scholar 

  133. Blumenfeld Z (2010) Fertility preservation and GnRH-a for chemotherapy: debate. Arch Gynecol Obstet 282:585–586

    PubMed  Google Scholar 

  134. Fageeh W, Raffa H, Jabbad H, Marzouki A (2002) Transplantation of the human uterus. Int J Gynecol Obstet 76:245–251

    CAS  Google Scholar 

  135. Eraslan S, Hamernik RJ, Hardy JD (1966) Replantation of uterus and ovaries in dogs, with successful pregnancy. Arch Surg 92:9–12

    PubMed  CAS  Google Scholar 

  136. Truta E, Pop I, Popa D, Ionescu M, Truta F (1969) Experimental re- and transplantation of the internal female genital organs. Rom Med Rev 13:53–58

    PubMed  CAS  Google Scholar 

  137. Barzilai A, Paldi E, Gal D, Hampel N (1973) Autotransplantation of the uterus and ovaries in dogs. Isr J Med Sci 9:49–52

    PubMed  CAS  Google Scholar 

  138. Racho El-Akouri R, Kurlberg G, Dindelegan G, Molne J, Wallin A, Brannstrom M (2002) Heterotopic uterine transplantation by vascular anastomosis in the mouse. J Endocrinol 174:157–166

    PubMed  CAS  Google Scholar 

  139. Wranning CA, Marcickiewicz J, Enskog A, Dahm-Kahler P, Hanafy A, Brannstrom M (2010) Fertility after autologous ovine uterine-tubal-ovarian transplantation by vascular anastomosis to the external iliac vessels. Hum Reprod 25:1973–1979

    PubMed  CAS  Google Scholar 

  140. Rideout 3rd WM, Eggan K, Jaenisch R (2001) Nuclear cloning and epigenetic reprogramming of the genome. Science 293(5532):1093–1098

    PubMed  CAS  Google Scholar 

  141. Hubner K, Fuhrmann G, Christenson LK, Kehler J, Reinbold R, De La Fuente R, Wood J, Strauss JF 3rd, Boiani M, Scholer HR (2003) Derivation of oocytes from mouse embryonic stem cells. Science 300(5623):1251–1256

    PubMed  Google Scholar 

  142. Geijsen N, Horoschak M, Kim K, Gribnau J, Eggan K, Daley GQ (2004) Derivation of embryonic germ cells and male gametes from embryonic stem cells. Nature 427(6970):148–154

    PubMed  CAS  Google Scholar 

  143. Friedrich MJ (2005) George Daley, MD, PhD, talks about the clinical promise of stem cell research. JAMA 293(7):787–789

    PubMed  CAS  Google Scholar 

  144. Rideout 3rd WM, Hochedlinger K, Kyba M, Daley GQ, Jaenisch R (2002) Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell 109(1):17–27

    PubMed  CAS  Google Scholar 

  145. Kono T, Obata Y, Wu Q, Niwa K, Ono Y, Yamamoto Y, Park ES, Seo JS, Ogawa H (2004) Birth of parthenogenetic mice that can develop to adulthood. Nature 428(6985):860–864

    PubMed  CAS  Google Scholar 

  146. de Wildt SN, Taguchi N, Koren G (2009) Unintended pregnancy during radiotherapy for cancer. Nat Clin Pract Oncol 6(3):175–178

    PubMed  Google Scholar 

  147. Mazonakis M, Varveris H, Fasoulaki M, Damilakis J (2003) Radiotherapy of Hodgkin’s disease in early pregnancy: embryo dose measurements. Radiother Oncol 66:333–339

    PubMed  Google Scholar 

  148. Nulman I, Laslo D, Fried S, Uleryk E, Lishner M, Koren G (2001) Neurodevelopment of children exposed in utero to treatment of maternal malignancy. Br J Cancer 85:1611–1618

    PubMed  CAS  Google Scholar 

  149. Partridge AH, Garber JE (2000) Long-term outcomes of children exposed to antineoplastic agents in utero. Semin Oncol 27:712–726

    PubMed  CAS  Google Scholar 

  150. Bar J, Davidi O, Goshen Y, Hod M, Yaniv I, Hirsch R (2003) Pregnancy outcome in women treated with doxorubicin for childhood cancer. Am J Obstet Gynecol 189:853–857

    PubMed  CAS  Google Scholar 

  151. Khan A, McNally D, Tutschka PJ, Bilgrami S (1997) Paclitaxel-induced acute bilateral pneumonitis. Ann Pharmacother 31(12):1471–1474

    PubMed  CAS  Google Scholar 

  152. Salooja N, Szydlo RM, Socie G, Rio B, Chatterjee R, Ljungman P, Van Lint MT, Powles R, Jackson G, Hinterberger-Fischer M, Kolb HJ, Apperley JF; Late Effects Working Party of the European Group for Blood and Marrow Transplantation (2001) Pregnancy outcomes after peripheral blood or bone marrow transplantation: A retrospective study. Lancet 358:271–276

    Google Scholar 

  153. Sanders JE, Hawley J, Levy W, Gooley T, Buckner CD, Deeq HJ, Doney K, Storb R, Sullivan K, Witherspoon R, Appelbaum FR (1996) Pregnancies following high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation and bone marrow transplantation. Blood 87:3045–3052

    PubMed  CAS  Google Scholar 

  154. Crane JM (2003) Pregnancy outcome after loop electrosurgical excision procedure: a systematic review. Obstet Gynecol 102:1058–1062

    PubMed  Google Scholar 

  155. Schlaerth JB, Spirtos NM, Schlaerth AC (2003) Radical trachelectomy and pelvic lymphadenectomy with uterine preservation in the treatment of cervical cancer. Am J Obstet Gynecol 188:29–34

    PubMed  Google Scholar 

  156. Fossa SD, Magelssen H, Melve K, Jacobsen AB, Langmark F, Skjaerven R (2005) Parenthood in survivors after adulthood cancer and perinatal health in their offspring: A preliminary report. J Natl Cancer Inst Monogr 34:77–82

    PubMed  Google Scholar 

  157. Partridge AH, Gelber S, Peppercorn J, Sampson E, Knudsen K, Laufer M, Rosenberg R, Przypyszny M, Rein A, Winer EP (2004) Web-based survey of fertility issues in young women with breast cancer. J Clin Oncol 22:4174–4183

    PubMed  Google Scholar 

  158. American Cancer Society http://www.cancer.gov. Accessed 2 May 2011

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Authors and Affiliations

  1. Center for Infertility and Reproductive Surgery, Brigham and Women’s Hospital, Boston, MA, 02115, USA

    Amelia P. Bailey MD

  2. In Vitro Fertilization Program Brigham & Women’s Hospital, Boston, MA, USA

    Elizabeth S. Ginsburg MD

Authors
  1. Amelia P. Bailey MD
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  2. Elizabeth S. Ginsburg MD
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Correspondence to Amelia P. Bailey MD .

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Editors and Affiliations

  1. Moffitt Cancer Center, Magnolia Drive 12902, Tampa, 33612, Florida, USA

    Gwendolyn P. Quinn

  2. Moffitt Cancer Center, Magnolia Drive 12902, Tampa, 33612, Florida, USA

    Susan T. Vadaparampil

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Bailey, A.P., Ginsburg, E.S. (2012). Fertility Preservation Options for Females. In: Quinn, G., Vadaparampil, S. (eds) Reproductive Health and Cancer in Adolescents and Young Adults. Advances in Experimental Medicine and Biology, vol 732. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2492-1_2

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