Abstract
During the twentieth century human life expectancy at birth increased by almost 30 years in developed countries and in the twenty-first century it is continuing to rise about 2 months in every year. Currently this is due mainly to medical advances reducing mortality from cardiovascular disease and cancer. In the twenty-first century the epidemic of obesity caused by overeating and reduced physical exercise is threatening to inhibit this continuing gain in human life expectancy. Life-long calorie restriction (CR) in the rat, mouse and the rhesus monkey retard aging, delay the onset of age-related diseases and significantly prolong life. Human 20% CR studies over 2–6 years reduce the risk factors for cardiovascular disease and diabetes. Okinawans, the longest-lived people on earth have been eating 20–40% less food than the Americans for half their life and live 4 years longer. Thus, calorie restriction has only a small impact on human life expectancy compared with the achievements of medicine, which continue to extend human life.
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References
Alberti, G., Zimmer, P., Shaw, J., Bloomgarten, Z., Kaufman, F. and Silink, M. and Consensus Workshop Group, 2004. Type 2 diabetes in the young: the evolving epidemic. Diabetes Care 27, 1798–1811.
Ayala, V., Naudi, A., Sanz, A., Caro, P., Portero-Otin, M., Barja, G. and Pamplona, R., 2007. Dietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liver. J Gerontol A Biol Sci Med Sci 62, 352–360.
Bartke, A. and Brown-Brog, H., 2004. Life extension in the dwarf mouse. In Current Topics in Developmental Biology, Vol. 63, Academic Press, San Diego, pp. 189–225.
Barzilai, N. and Shildiner, A. R., 2001. Searching for human longevity genes: the future history of gerontology in the post-genomic era. J Gerontol A Biol Sci Med Sci 56, M 83–87.
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V. et al., 2006. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337–342.
Bazzano, L. A., Li, T. Y., Joshipura, K. J. and Hu, F. B., 2008. Intake of fruit, vegetables, and fruit juices and risk of diabetes in women. Diabetes Care 31, 1311–1317.
Bessesen, D. H., 2008. Update on obesity. J Clin Endocr Metab 93, 2027–2034.
Brawer, R., Brisbon, N. and Plumb, J., 2009. Obesity and cancer. Prim Care 36, 509–531.
Catford, J. C. and Caterson, I. D., 2003. Snowballing obesity: Australians will get run over if they just sit there. MJA 179, 577–579.
Christou, N. V., Sampalis, J. S., Liberman, M., Look, D., Auger, S., McLean, P. H. and MacLean, L. D., 2004. Surgery decreases long-term mortality, morbidity and health care use in morbidly obese patients. Ann Surg 240, 416–424.
Chung, H. Y., Kim, H. J., Kim, J. W. and Yu, B. P., 2001. The inflammation hypothesis of aging: molecular modification by calorie restriction. Ann NY Acad Sci 928, 327–335.
Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, S. C., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W. and Weindruch, R., 2009. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325, 201–204.
Dehghan, M., Akhtar-Danesh, N. and Merchant, A. T., 2005. Childhood obesity, prevalence and prevention. Nutr J 4, 24.
Everitt, A. V., 1971. The hormonal control of ageing and longevity. Proc Aust Assoc Gerontol 1, 127–132.
Flachsbart, F., Caliebe, A., Kleindorp, R., Blanche, H., von Eller-Eberstein, H., Nikolaus, S., Schreiber, S. and Nebel, A., 2009. Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc Natl Acad Sci USA 106, 2700–2705.
Fontana, L., Meyer, T., Klein, S. and Holloszy, J. O., 2004. Long-term caloric restriction is highly effective in reducing the risk of atherosclerosis in humans. Proc Natl Acad Sci USA 101, 6659–6663.
Fontana, L., Weiss, E. P., Villareal, D. T., Klein, S. and Holloszy, J. O., 2008. Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell 7, 681–687.
Genedani, S., Filaferro, M., Carone, C., Ostan, R., Bucci, L., Cervenini, E., Franceschi, C. and Monti, D., 2008. Influence of f-MLP, ACTH(1-24) and CRH on in vitro chemotaxis of monocytes from centenarians. Neuroimmunomodulation 15, 285–289.
Goodwin, J. S. and Brodwick, M., 1995. Diet, aging and cancer. Clin Geriatric Med 11, 577–589.
Holloszy, J. O. and Fontana, L., 2007. Caloric restriction in humans. Exp Gerontol 42, 709–712.
Hunt, N. D., Hyun, D. H., Allard, J. S., Minor, R. K., Mattson, M. P., Ingram, D. K. and de Cabo, R., 2006. Bioenergetics of aging and calorie restriction. Ageing Res Rev 5, 125–143.
Hursting, S. D., Lavigne, J. A. and Berrigan, D., 2003. Calorie restriction, aging, and cancer Prevention: mechanisms of action and applicability to humans. Annu Rev Med 54, 131–152.
Le Couteur, D. G., Everitt, A. V. and Lebel, M., 2009. The aging liver. Geriatr Aging 12, 319–322.
Masoro, E. J., 1998. Hormesis and the antiaging action of dietary restriction. Exp Gerontol 31, 61–66.
Masoro, E. J., 2005. Overview of calorie restriction and ageing. Mech Ageing Dev 126, 913–922.
McCay, C. M., Crowell, M. and Maynard, L. A., 1935. The effect of retarded growth upon length of the lifespan and ultimate body size. J Nutr 10, 63–79.
Mirmiran, P., Noori, N., Zavarih, M. B. and Azizi, F., 2009. Fruit and vegetable consumption and risk factors for cardiovascular disease. Metabolism 58, 460–468.
Olshansky, S. L., Passoro, D. J., Hershoy, R. C., Layden, J., Carnes, B. A., Brody, J., Hayflick, A., Butler, R. N., Allison, D. B. and Ludwig, D. S., 2005. A potential decline in life expectancy in the United States in the 21st century. N Engl J Med 352, 1138–1145.
Renehan, A. G., Tyson, M., Egger, M., Heller, R. F. and Zwallen, M., 2008. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371, 569–578.
Riboli, E. and Norat, T., 2003. Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am J Clin Nutr 78, 559S–569S.
Sjostrom, L., Lindroos, A. K., Peltonen, M., Torgerson, J., Bouchard, C., Carlsson, B., Dahlgren, S., Larsson, B., Narbro, K., Sjostrom, C. D., Sullivan, M. and Wedel, H. and Swedish Obese Subjects Study Scientific Group, 2004. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med 351, 2683–2693.
Sohal, R. S., Mockett, R. J. and Orr, W. C., 2002. Mechanisms of aging: an appraisal of the oxidative stress hypothesis. Free Radic Biol Med 33, 575–586.
Tiffen, R. and Gittins, R., 2004. How Australia Compares. Cambridge University Press, Cambridge.
Treadwell, J. R., Sun, F. and Schoelles, K., 2008. Systematic review and meta-analysis of bariatric surgery for pediatric obesity. Ann Surg 248, 763–776.
Tuomilehto, J., Lindstrom, J., Eriksson, J. G., Valle, T. T., Hamalainen, H., Ilanne-Parikka, P. et al., 2001. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344, 1343–1350.
Van Dam, R. M., Li, T., Spiegelman, D., Franco, O. H. and Hu, F. B., 2008. Combined impact of lifestyle factors on mortality. Prospective cohort study in US women. BMJ 337, a1440.
Vaupel, J. W., 1997. The remarkable improvements in survival at older ages. Philos Trans R Soc Lond B Biol Sci 352, 1799–1804.
Walford, R. L., Mock, D., Verdery, R. and MacCallum, T., 2002. Calorie restriction in Biosphere 2: alterations in physiologic, hematologic, and biochemical parameters in humans restricted for a 2 year period. J Gerontol A Biol Sci Med Sci 57, B211–B222.
Waters, E. B. and Baur, L. A., 2003. Childhood obesity: modernity’s scourge. MJA 178, 422–423.
Weindruch, R. and Walford, R. L., 1988. The Retardation of Aging and Disease by Dietary Restriction. CC Thomas, Springfield IL.
Whalley, L. J., Starr, J. M. and Deary, I. J., 2004. Review. Diet and dementia. Menopause Int 10, 113–117.
Willcox, D. C., Willcox, B. J., Todoriki, H., Curb, J. D. and Suzuki, M., 2006. Caloric restriction and human longevity: what can we learn from the Okinawans?. Biogerontology 7, 173–177.
Willi, S. M., Martin, K., Datko, F. M. and Braut, B. P., 2004. Treatment of type 2 diabetes in childhood using a very low-calorie diet. Diabetes Care 27, 348–353.
Yates, L. B., Djousse, L., Kurth, T., Buring, J. E. and Gaziano, J. M., 2008. Exceptional longevity in men. Modifiable facrors associated with survival and function to age 90 years. Arch Intern Med 168, 284–290.
Yuan, R., Tsaih, S. W., Petkova, S. B., de Evsikova, C. M., Xing, S., Marion, M. A. et al., 2009. Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell 8, 277–287.
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Everitt, A.V. et al. (2010). Conclusion: Human Calorie Restriction and Anti-aging Therapy. In: Everitt, A., Rattan, S., le Couteur, D., de Cabo, R. (eds) Calorie Restriction, Aging and Longevity. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8556-6_18
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DOI: https://doi.org/10.1007/978-90-481-8556-6_18
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