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ω-3 PUFAs and Other Cancers

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Book cover Dietary Omega-3 Polyunsaturated Fatty Acids and Cancer

Part of the book series: Diet and Cancer ((DICA,volume 1))

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Abstract

ω-3 Polyunsaturated fatty acids (ω-3 PUFAs)-rich fish oil is thought to suppress the pathogenesis of several human diseases including cancer. Although systemic reviews of epidemiological and cohort studies on cancer prevention of fish oil have provided controversial results, many preclinical studies convincingly demonstrate preventive and therapeutic efficacies of ω-3 PUFAs on cancer growth, angiogenesis, and metastasis through diverse mechanisms. This chapter summarizes the mechanisms of anticancer action of ω-3 PUFAs in pancreatic cancer, lung cancer, skin cancer, cholangiocarcinoma, and leukemia. By understanding these mechanisms we will be able to recommend the utilization of ω-3 PUFAs, alone or in combination with standard anticancer drugs, as an effective and safe therapeutic approach for the chemoprevention and treatment of these human cancers.

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Acknowledgment

This work was supported by the Korea Science & Engineering Foundation through the Infection Signaling Network Research Center (R13-2007-020-01000-0) and the Korea government (MEST) (#2009-0073970).

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  1. Department of Biochemistry Cancer Research Institute and Infection Signaling Network Research Center College of Medicine, Chungnam National University, Daejeon, Korea

    Kyu Lim

  2. Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Tong Wu

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    Gabriella Calviello

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    Simona Serini

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Lim, K., Wu, T. (2010). ω-3 PUFAs and Other Cancers. In: Calviello, G., Serini, S. (eds) Dietary Omega-3 Polyunsaturated Fatty Acids and Cancer. Diet and Cancer, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3579-0_8

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