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Major Surgery in BIONJ

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Abstract

Major surgery in BIONJ should be considered only for patients with stage III disease and large lesions. In this chapter, the characteristics of patients who are candidates for major surgery are described. We also discuss the methods used in jawbone resection, reconstruction of secondary defects, and the resolution of complications in advanced-stage disease.

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References

  1. Vieillard MH, Maes JM, Penel G et al (2008) Thirteen cases of jaw osteonecrosis in patients on bisphosphonate therapy. Jt Bone Spine 75:34–40

    Article  Google Scholar 

  2. Ruggiero SL, Fantasia J, Carlson E (2006) Bisphosphonate-related osteonecrosis of the jaw: background and guidelines for diagnosis, staging and management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:433–441

    Article  PubMed  Google Scholar 

  3. Kademani D, Koka S, Lacy MQ, Rajkuma SV (2006) Primary surgical therapy for osteonecrosis of the jaw secondary to bisphosphonate therapy. Mayo Clin Proc 81(8):1100–1103

    Article  PubMed  Google Scholar 

  4. Bedogni A, Saia G, Ragazzo M et al (2007) Bisphosphonate-associated osteonecrosis can hide jaw metastases. Bone 41:942–945

    Article  PubMed  CAS  Google Scholar 

  5. Ferrari S, Bianchi B, Savi A et al (2008) Fibula free flap with endosseous implants for reconstructing a resected mandible in bisphosphonate osteonecrosis. J Oral Maxillofac Surg 66:999–1003

    Article  PubMed  Google Scholar 

  6. Longobardi G, Boniello R, Gasparini G, Pagano I, Pelo S (2007) Surgical therapy for osteonecotic lesions of the jaws in patients in therapy with bisphosphonates. J Craniofac Surg 18(5):1012–1017

    Article  PubMed  Google Scholar 

  7. Krueger CD, West PM, Sargent M, Lodolce AE, Pickard AS (2007) Bisphosphonate-induced osteonecrosis of the jaw. Ann Pharmacother 41(2):276–284

    Article  PubMed  CAS  Google Scholar 

  8. Tirelli G, Biasotto M, Chiandussi S et al (2009) Bisphosphonate-associated osteonecrosis of the jaws: the limits of a conservative approach. Head Neck. doi:10.1002/hed

  9. Vassiliou V, Tselis N, Kardamakis D (2010) Osteonecrosis of the jaws: clinicopathologic and radiologic characteristics, preventive and therapeutic strategies. Strahlenther Onkol 186(7):367–373

    Article  PubMed  Google Scholar 

  10. Williamson RA (2010) Surgical management of bisphosphonate induced osteonecrosis of the jaws. Int J Oral Maxillofac Surg 39(3):251–255

    Article  PubMed  CAS  Google Scholar 

  11. Rustemeyer J, Bremerich A (2010) Bisphosphonate-associated osteonecrosis of the jaw: what do we currently know? A survey of knowledge given in the recent literature. Clin Oral Investig 14(1):59–64

    Article  PubMed  Google Scholar 

  12. Stockmann P, Vairaktaris E, Wehrhan F et al (2010) Osteotomy and primary wound closure in bisphosphonate-associated osteonecrosis of the jaw: a prospective clinical study with 12 months follow-up. Support Care Cancer 18(4):449–460

    Article  PubMed  Google Scholar 

  13. Khan AA, Sándor GK, Dore E et al (2009) Bisphosphonate associated osteonecrosis of the jaw. J Rheumatol 36(3):478–490

    Article  PubMed  Google Scholar 

  14. Alons K, Kuijpers SC, de Jong E, van Merkesteyn JP (2009) Treating low- and medium-potency bisphosphonate-related osteonecrosis of the jaws with a protocol for the treatment of chronic suppurative osteomyelitis: report of 7 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107(2):e1–e7

    Article  PubMed  Google Scholar 

  15. Diego R, D’Orto O, Pagani D et al (2007) Bisphosphonate-associated osteonecrosis of the jaws: a therapeutic dilemma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103(3):e1–e5

    Article  PubMed  Google Scholar 

  16. Neumann B, Gregersen H (2006) Bisphosphonates and osteonecrosis of the jaws in patients with myelomatosis. Ugeskr Laeger 168(21):2078–2079

    PubMed  Google Scholar 

  17. Engroff SL, Coletti D (2008) Bisphosphonate related osteonecrosis of the palate: report of a case managed with free tissue transfer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:580–582

    Article  PubMed  Google Scholar 

  18. Stanton DC, Balasanian E (2009) Outcome of surgical management of bisphosphonate-related osteonecrosis of the jaws: review of 33 surgical cases. J Oral Maxillofac Surg 67:943–950

    Article  PubMed  Google Scholar 

  19. Nocini PF, Saia G, Bettini G, Ragazzo M, Blandamura S, Chiarini L, Bedogni A (2009) Vascularized fibula flap reconstruction of the mandible in bisphosphonate-related osteonecrosis. Eur J Surg Oncol 35:373–379

    Article  PubMed  CAS  Google Scholar 

  20. Bedogni A, Bettini G, Totola A, Saia G, Nocini PF (2010) Oral bisphosphonate-associated osteonecrosis of the jaw after implant surgery: a case report and literature review. J Oral Maxillofac Surg 68:1662–1666

    Article  PubMed  Google Scholar 

  21. Wongchuensoontorn C, Liebehenschel N, Wagner K et al (2009) Pathological fractures in patients caused by bisphosphonate-related osteonecrosis of the jaws: report of 3 cases. J Oral Maxillofac Surg 67:1311–1316

    Article  PubMed  Google Scholar 

  22. Vaszilkó M, Barabás J, Szabó G, Velich N, Cséplo K, Ujpál M (2007) Osteonecrosis of the jaws by using bisphosphonates. Fogorv Sz 100(3):115–119

    PubMed  Google Scholar 

  23. Farrugia MC, Summerlin DJ, Krowiak E et al (2006) Osteonecrosis of the mandible or maxilla associated with the use of new generation bisphosphonates. Laryngoscope 116(1):115–120

    Article  PubMed  Google Scholar 

  24. Carlson ER, Basile JD (2009) The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg 67(Suppl 1):85–95

    Article  PubMed  Google Scholar 

  25. McLeod NM, Davies BJ, Brennan PA (2009) Management of patients at risk of bisphosphonate osteonecrosis in maxillofacial surgery units in the UK. Surgeon 7(1):18–23

    Article  PubMed  CAS  Google Scholar 

  26. Wutzl A, Biedermann E, Wanschitz F et al (2008) Treatment results of bisphosphonate-related osteonecrosis of the jaws. Head Neck 30(9):1224–1230

    Article  PubMed  Google Scholar 

  27. Marx RE (2009) Reconstruction of defects caused by bisphosphonate-induced osteonecrosis of the jaws. J Oral Maxillofac Surg 67(Suppl 1):107–119

    Article  PubMed  Google Scholar 

  28. Coletti D, Ord RA (2008) Treatment rationale for pathological fractures of the mandible: a series of 44 fractures. Int J Oral Maxillofac Surg 37:216

    Article  Google Scholar 

  29. Adornato MC, Morcos I, Rozanski J (2007) The treatment of bisphosphonate-associated osteonecrosis of the jaws with bone resection and autologous platelet-derived growth factors. J Am Dent Assoc 138:971–977

    PubMed  Google Scholar 

  30. Pirih FQ, Zablotsky M, Cordell K, McCauley LK (2009) Case report of implant placement in a patient with Paget’s disease on bisphosphonate therapy. J Mich Dent Assoc 91(5):38–43

    PubMed  Google Scholar 

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Correspondence to Francesco Saverio De Ponte .

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© 2012 Springer Milan

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Catalfamo, L., Nava, C., Lombardo, G., De Ponte, F.S. (2012). Major Surgery in BIONJ. In: De Ponte, F. (eds) Bisphosphonates and Osteonecrosis of the Jaw: A Multidisciplinary Approach. Springer, Milano. https://doi.org/10.1007/978-88-470-2083-2_14

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  • DOI: https://doi.org/10.1007/978-88-470-2083-2_14

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  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2082-5

  • Online ISBN: 978-88-470-2083-2

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