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Diagnostica per immagini: TC ed ecografia

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Tumori della testa e del collo

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Nei tumori del distretto testa-collo, l’impiego della tomografia computerizzata (TC) e dell’ecografia (US) consente l’acquisizione di informazioni critiche nella diagnosi, nella stadiazione, nel monitoraggio della risposta al trattamento e nel follow-up.

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Bibliografia

  1. Richards PS, Peacock TE (2007) The role of ultrasound in the detection of cervical lymph node metastases in clinically N0 squamous cell carcinoma of the head and neck. Cancer Imaging 7:167–178

    Article  PubMed  CAS  Google Scholar 

  2. van Gils AP, van den Berg R et al (1994) MR diagnosis of paraganglioma of the head and neck: value of contrast enhancement. AJR Am J Roentgenol 162:147–153

    PubMed  Google Scholar 

  3. Keberle M, Tschammler A et al (2002) Single-bolus technique for spiral CT of laryngopharyngeal squamous cell carcinoma: comparison of different contrast material volumes, flow rates, and start delays. Radiology 224:171–176

    Article  PubMed  Google Scholar 

  4. Surlan-Popovic K, Bisdas S et al Changes in perfusion CT of advanced squamous cell carcinoma of the head and neck treated during the course of concomitant chemoradiotherapy. AJNR Am J Neuroradiol 31:570–575

    Google Scholar 

  5. Bisdas S, Rumboldt Z et al Perfusion CT in squamous cell carcinoma of the upper aerodigestive tract: long-term predictive value of baseline perfusion CT measurements. AJNR Am J Neuroradiol 31:576–581

    Google Scholar 

  6. Bisdas S, Rumboldt Z et al (2009) Response and progression-free survival in oropharynx squamous cell carcinoma assessed by pretreatment perfusion CT: comparison with tumor volume measurements. AJNR Am J Neuroradiol 30:793–799

    Article  PubMed  CAS  Google Scholar 

  7. Baatenburg de Jong RJ, Rongen RJ (1993) Ultrasound of the head and neck. ORL J Otorhinolaryngol Relat Spec 55:250–257

    Article  Google Scholar 

  8. Krestan C, Herneth AM et al (2006) Modern imaging lymph node staging of the head and neck region. Eur J Radiol 58:360–366

    Article  PubMed  CAS  Google Scholar 

  9. Takashima S, Fukuda H et al (1995) Thyroid nodules: reevaluation with ultrasound. J Clin Ultrasound 23:179–184

    Article  PubMed  CAS  Google Scholar 

  10. Zenk J, Bozzato A et al (2005) Metastatic and inflammatory cervical lymph nodes as analyzed by contrast-enhanced color-coded Doppler ultrasonography: quantitative dynamic perfusion patterns and histopathologic correlation. Ann Otol Rhinol Laryngol 114:43–47

    PubMed  Google Scholar 

  11. van den Brekel MW, Castelijns JA et al (1991) Occult metastatic neck disease: detection with US and US-guided fine-needle aspiration cytology. Radiology 180:457–461

    PubMed  Google Scholar 

  12. Colnot DR, Nieuwenhuis EJ et al (2001) Head and neck squamous cell carcinoma: US-guided fine-needle aspiration of sentinel lymph nodes for improved staging—initial experience. Radiology 218:289–293

    PubMed  CAS  Google Scholar 

  13. Kraft M, Laeng H et al (2008) Comparison of ultrasoundguided core-needle biopsy and fine-needle aspiration in the assessment of head and neck lesions. Head Neck 30:1457–1463

    Article  PubMed  Google Scholar 

  14. Chan JM, Shin LK et al (2007) Ultrasonography of abnormal neck lymph nodes. Ultrasound Q 23:47–54

    Article  PubMed  Google Scholar 

  15. Johansen J, Buus S et al (2008) Prospective study of 18FDG-PET in the detection and management of patients with lymph node metastases to the neck from an unknown primary tumor. Results from the DAHANCA-13 study. Head Neck 30:471–478

    Article  PubMed  Google Scholar 

  16. Hamoir M, Bernheim N et al (2005) Initial assessment of a neck mass in children. B-ENT Suppl 1:126–128

    Google Scholar 

  17. Zielke AM, Swischuk LE et al (2007) Ectopic cervical thymic tissue: can imaging obviate biopsy and surgical removal? Pediatr Radiol 37:1174–1177

    Article  PubMed  Google Scholar 

  18. Gritzmann N (2005) Sonography of the neck: current potentials and limitations. Ultraschall Med 26:185–196

    Article  PubMed  CAS  Google Scholar 

  19. Venema HW, den Heeten GJ (2003) Subtraction helical CT angiography of intra-and extracranial vessels: technical considerations and preliminary experience—rediscovery of matched mask bone elimination? AJNR Am J Neuroradiol 24:1491

    PubMed  Google Scholar 

  20. Kim JJ, Dillon WP et al Sixty-four-section multidetector CT angiography of carotid arteries: a systematic analysis of image quality and artifacts. AJNR Am J Neuroradiol 31:91–99

    Google Scholar 

  21. Chong VF, Khoo JB et al (2004) Imaging of the nasopharynx and skull base. Neuroimaging Clin N Am 14:695–719

    Article  PubMed  Google Scholar 

  22. Maroldi R, Ambrosi C et al (2005) Metastatic disease of the brain: extra-axial metastases (skull, dura, leptomeningeal) and tumour spread. Eur Radiol 15:617–626

    Article  PubMed  Google Scholar 

  23. Lee CC, Huang TT et al Clinical application of tumor volume in advanced nasopharyngeal carcinoma to predict outcome. Radiat Oncol 5:20

    Google Scholar 

  24. Rasch CR, Steenbakkers RJ et al Decreased 3D observer variation with matched CT-MRI, for target delineation in Nasopharynx cancer. Radiat Oncol 5:21

    Google Scholar 

  25. Manavis J, Sivridis L et al (2005) Nasopharyngeal carcinoma: the impact of CT-scan and of MRI on staging, radiotherapy treatment planning, and outcome of the disease. Clin Imaging 29:128–133

    PubMed  Google Scholar 

  26. Guido A, Fuccio L et al (2009) Combined 18F-FDG-PET/CT imagingin radiotherapy target delineation for headand-neck cancer. Int J Radiat Oncol Biol Phys 73:759–763

    Article  PubMed  Google Scholar 

  27. Gardner M, Halimi P et al (2009) Use of single MRI and 18F-FDG PET-CT scans in both diagnosis and radiotherapy treatment planning in patients with head and neck cancer: advantage on target volume and critical organ delineation. Head Neck 31:461–467

    Article  PubMed  Google Scholar 

  28. Comoretto M, Balestreri L et al (2008) Detection and restaging of residual and/or recurrent nasopharyngeal carcinoma after chemotherapy and radiation therapy: comparison of MR imaging and FDG PET/CT. Radiology 249:203–211

    Article  PubMed  Google Scholar 

  29. Lenz M, Greess H et al (2000) Oropharynx, oral cavity, floor of the mouth: CT and MRI. Eur J Radiol 33:203–215

    Article  PubMed  CAS  Google Scholar 

  30. Tshering Vogel DW, Zbaeren P et al Cancer of the oral cavity and oropharynx. Cancer Imaging 10:62–72

    Google Scholar 

  31. Seitz O, Chambron-Pinho N et al (2009) 18F-Fluorodeoxyglucose-PET/CT to evaluate tumor,nodal disease, and gross tumor volume of oropharyngeal and oral cavity cancer: comparison with MR imaging and validation with surgical specimen. Neuroradiology 51:677–686

    Article  PubMed  Google Scholar 

  32. Maroldi R, Farina D et al (2008) Perineural tumor spread. Neuroimaging Clin N Am 18:413–429

    Article  PubMed  Google Scholar 

  33. Keberle M, Jenett M et al (2000) [New possibilities in the diagnosis and documentation using 3D power doppler ultrasound with carcinoma of the floor of the mouth as illustration]. Ultraschall Med 21:26–31

    Article  PubMed  CAS  Google Scholar 

  34. Mukherji SK, Weeks SM et al (1996) S quamous cell carcinomas that arise in the oral cavity and tongue base: can CT help predict perineural or vascular invasion? Radiology 198:157–162

    PubMed  CAS  Google Scholar 

  35. Mukherji SK, Isaacs DL et al (2001) CT detection of mandibular invasion by squamous cell carcinoma of the oral cavity. AJR Am J Roentgenol 177:237–243

    PubMed  CAS  Google Scholar 

  36. Bolzoni A, Cappiello J et al (2004) Diagnostic accuracy of magnetic resonance imaging in the assessment of mandibular involvement in oral-oropharyngeal squamous cell carcinoma: a prospective study. Arch Otolaryngol Head Neck Surg 130:837–843

    Article  PubMed  Google Scholar 

  37. Maroldi R, Battaglia G et al (1999) Tumours of the oropharynx and oral cavity: perineural spread and bone invasion. JBR-BTR 82:294–300

    PubMed  CAS  Google Scholar 

  38. Lell MM, Greess H et al (2004) Multiplanar functional imaging of the larynx and hypopharynx with multislice spiral CT. Eur Radiol 14:2198–2205

    Article  PubMed  Google Scholar 

  39. Keberle M, Kenn W et al (2002) Current concepts in imaging of laryngeal and hypopharyngeal cancer. Eur Radiol 12:1672–1683

    Article  PubMed  CAS  Google Scholar 

  40. Schmalfuss IM (2004) Imaging of the hypopharynx and cervical esophagus. Neuroimaging Clin N Am 14:647–662

    Article  PubMed  Google Scholar 

  41. Pameijer FA, Mukherji SK et al (1998) Imaging of squamous cell carcinoma of the hypopharynx. Semin Ultrasound CT MR 19:476–491

    Article  PubMed  CAS  Google Scholar 

  42. Chen SW, Yang SN et al (2006) Value of computed tomography-based tumor volume as a predictor of outcomes in hypopharyngeal cancer after treatment with definitive radiotherapy. Laryngoscope 116:2012–2017

    Article  PubMed  Google Scholar 

  43. Bisdas S, Nguyen SA et al (2009) Outcome prediction after surgery and chemoradiation of squamous cell carcinoma in the oral cavity, oropharynx, and hypopharynx: use of baseline perfusion CT microcirculatory parameters vs. tumor volume. Int J Radiat Oncol Biol Phys 73:1313–1318

    Article  PubMed  Google Scholar 

  44. Ng SH, Chan SC et al (2008) Distant metastases and synchronous second primary tumors in patients with newly diagnosed oropharyngeal and hypopharyngeal carcinomas: evaluation of (18)F-FDG PET and extended-field multi-detector row CT Neuroradiology 50:969–979

    Google Scholar 

  45. Conessa C, Hervé S et al (2004) FDG-PET scan in local follow-up of irradiated head and neck squamous cell carcinomas. Ann Otol Rhinol Laryngol 113:628–635

    PubMed  Google Scholar 

  46. Maroldi R, Battaglia G et al (1996) Computed tomography scanning of supraglottic neoplasms: its cost-effective use in preoperative staging. Acad Radiol 3Suppl 1:S57–59

    Article  PubMed  Google Scholar 

  47. Remacle M, Hantzakos A et al (2009) Endoscopic supraglottic laryngectomy: a proposal for a classification by the working committee on nomenclature, European Laryngological Society. Eur Arch Otorhinolaryngol 266:993–998

    Article  PubMed  Google Scholar 

  48. Zbaren P, Becker M et al (1996) Pretherapeutic staging of laryngeal carcinoma. Clinical findings, computed tomography, and magnetic resonance imaging compared with histopathology. Cancer 77:1263–1273

    CAS  Google Scholar 

  49. Loev ner LA, Yousem DM et al (1997) Can radiologists accurately predict preepiglottic space invasion with MR imaging? AJR Am J Roentgenol 169:1681–1687

    CAS  Google Scholar 

  50. Freeman DE, Maneuso AA et al (1990) Irradiation alone for supraglottic larynx carcinoma: can CT findings predict treatment results? Int J Radiat Oncol Biol Phys 19:485–490

    Article  PubMed  CAS  Google Scholar 

  51. Barbosa MM, Araujo VJ, Jr et al (2005) Anterior vocal commissure invasion in laryngeal carcinoma diagnosis. Laryngoscope 115:724–730

    Article  PubMed  CAS  Google Scholar 

  52. Becker M, Burkhardt K et al (2008) Imaging of the larynx and hypopharynx. Eur J Radiol 66:460–479

    Article  PubMed  Google Scholar 

  53. Becker M, Zbaren P et al (2008) Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. Radiology 249:551–559

    Article  PubMed  Google Scholar 

  54. Becker M, Burkhardt K et al (2009) Pra-und posttherapeutische Larynxbildgebung. Radiologe 49:43–58

    Article  PubMed  CAS  Google Scholar 

  55. Becker M (2000) Neoplastic invasion of laryngeal cartilage: radiologic diagnosis and therapeutic implications. Eur J Radiol 33:216–229

    Article  PubMed  CAS  Google Scholar 

  56. Beitier JJ, Muller S et al Prognostic accuracy of computed tomography findings for patients with laryngeal cancer undergoing laryngectomy. J Clin Oncol 28:2318–2322

    Google Scholar 

  57. Gordin A, Daitzchman M et al (2006) Fluorodeoxyglucose-positron emission tomography/computed tomography imaging in patients with carcinoma of the larynx: diagnostic accuracy and impact on clinical management. Laryngoscope 116:273–278

    Article  PubMed  Google Scholar 

  58. Brouwer J, Hooft L et al (2008) Systematic review: accuracy of imaging tests in the diagnosis of recurrent laryngeal carcinoma after radio therapy. Head Neck 30:889–897

    Article  PubMed  Google Scholar 

  59. de Bree R, van der Putten L et al (2009) Detection of locoregional recurrent head and neck cancer after (chemo)radiotherapy using modern imaging. Oral Oncol 45:386–393

    Article  PubMed  Google Scholar 

  60. Pameijer FA, Hermans R et al (1999) Pre-and post-radiotherapy computed tomography in laryngeal cancer: imaging-based prediction of local failure. Int J Radiat Oncol Biol Phys 45:359–366

    PubMed  CAS  Google Scholar 

  61. Bely-Toueg N, Halimi P et al (2001) Normal laryngeal CT findings after supracricoid partial laryngectomy. AJNR Am J Neuroradiol 22:1872–1880

    PubMed  CAS  Google Scholar 

  62. Maroldi R, Battaglia G et al (1997) CT appearance of the larynx after conservative and radical surgery for carcinomas. Eur Radiol 7:418–431

    Article  PubMed  CAS  Google Scholar 

  63. Ferreiro-Arguelles C, Jimenez-Juan L et al (2008) CT findings after laryngectomy. Radiographics 28:869–882

    Article  PubMed  Google Scholar 

  64. Lee JH, Sohn JE et al (2000) Sonographic findings of the neopharynx after total laryngectomy: comparison with CT. AJNR Am J Neuroradiol 21:823–827

    PubMed  CAS  Google Scholar 

  65. Lund VJ, Stammberger H et al European position paper on endoscopic management of tumours of the nose, paranasal sinuses and skull base. Rhinol: 1-143

    Google Scholar 

  66. Maroldi R, Farina D et al (1997) MR of malignant nasos-inusal neoplasms. Frequently asked questions. Eur J Radiol 24:181–190

    Article  PubMed  CAS  Google Scholar 

  67. Kim HJ, Lee TH et al (2006) Periorbita: computed tomography and magnetic resonance imaging findings. Am J Rhinol 20:371–374

    Article  PubMed  Google Scholar 

  68. Nicolai P, Battaglia P et al (2008) Endoscopic surgery for malignant tumors of the sinonasal tract and adjacent skull base: a 10-year experience. Am J Rhinol 22:308–316

    Article  PubMed  Google Scholar 

  69. Nicolai P, Castelnuovo P et al (2007) Role of endoscopic surgery in the management of selected malignant epithelial neoplasms of the naso-ethmoidal complex. Head Neck 29:1075–1082

    Article  PubMed  Google Scholar 

  70. Dillon WP, Som PM et al (1990) Hypointense MR signal in chronically inspissated sinonasal secretions. Radiology 174:73–78

    PubMed  CAS  Google Scholar 

  71. Chisholm EJ, Mendoza N et al (2008) Fused CT and angiography image guided surgery for endoscopic skull base procedures: how we do it. Clin Otolaryngol 33:625–628

    Article  PubMed  CAS  Google Scholar 

  72. Gritzmann N, Rettenbacher T et al (2003) Sonography of the salivary glands. Eur Radiol 13:964–975

    PubMed  CAS  Google Scholar 

  73. Bialek EJ, Jakubowski W et al (2006) US of the major salivary glands: anatomy and spatial relationships, pathologic conditions, and pitfalls. Radiographics 26:745–763

    Article  PubMed  Google Scholar 

  74. Kakimoto N, Gamoh S et al (2009) CT and MR images of pleomorphic adenoma in major and minor salivary glands. Eur J Radiol 69:464–472

    Article  PubMed  Google Scholar 

  75. Renehan A, Gleave EN et al (1996) Long-term follow-up of over 1000 patients with salivary gland tumours treated in a single centre. Br J Surg 83:1750–1754

    Article  PubMed  CAS  Google Scholar 

  76. Breeze J, Andi A et al (2009) The use of fine needle core biopsy under ultrasound guidance in the diagnosis of a parotid mass. Br J Oral Maxillofac Surg 47:78–79

    Article  PubMed  Google Scholar 

  77. de Ru JA, van Leeuwen MS et al (2007) Do magnetic resonance imaging and ultrasound add anything to the preoperative workup of parotid gland tumors? J Oral Maxillofac Surg 65:945–952

    Article  PubMed  Google Scholar 

  78. Raine C, Saliba K etal (2003) Radiological imaging in primary parotid malignancy. Br J Plast Surg 56:637–643

    Article  PubMed  CAS  Google Scholar 

  79. Freling NJ, Molenaar WM et al (1992) Malignant parotid tumors: clinical use of MR imaging and histologic correlation. Radiology 185:691–696

    PubMed  CAS  Google Scholar 

  80. Ginsberg LE (2004) MR imaging of perineural tumor spread. Neuroimaging Clin N Am 14:663–677

    Article  PubMed  Google Scholar 

  81. Rinaldo A, Ferlito A et al (2003) Management of malignant submandibular gland tumors. Acta Otolaryngol 123:896–904

    Article  PubMed  Google Scholar 

  82. Alyas F, Lewis K et al (2005) Diseases of the submandibular gland as demonstrated using high resolution ultrasound. Br J Radiol 78:362–369

    Article  PubMed  CAS  Google Scholar 

  83. Farina D, Hermans R et al (1999) Imaging of the parapharyngeal space. JBR-BTR 82234-239

    Google Scholar 

  84. Som PM, Shugar JM et al (1988) Benign and malignant parotid pleomorphic adenomas: CT and MR studies. J Comput Assist Tomogr 12:65–69

    Article  PubMed  CAS  Google Scholar 

  85. Mafee MF, Raofi B et al (2000) Glomus faciale, glomus jugulare, glomus tympanicum, glomus vagale, carotid body tumors, and simulating lesions. Role of MR imaging. Radiol Clin North Am 38:1059–1076

    Article  PubMed  CAS  Google Scholar 

  86. King AD, Tse GM et al (2004) Necrosis in metastatic neck nodes: diagnostic accuracy of CT, MR imaging, and US. Radiology 230:720–726

    Article  PubMed  Google Scholar 

  87. Sumi M, Ohki M et al (2001) Comparison of sonography and CT for differentiating benign from malignant cervical lymph nodes in patients with squamous cell carcinoma of the head and neck. AJR Am J Roentgenol 176:1019–1024

    PubMed  CAS  Google Scholar 

  88. King AD, Tse GM et al (2004) Comparison of CT and MR imaging for the detection of extranodal neoplastic spread in metastatic neck nodes. Eur J Radiol 52:264–270

    Article  PubMed  Google Scholar 

  89. Steinkamp HJ, van der Hoeck E et al (1999) Kapseldurchbruche zervikaler Lymphknotenmetastasen: diagnostischer Stellenwert der Computertomographie. Rofo 170:457–462

    PubMed  CAS  Google Scholar 

  90. Steinkamp HJ, Beck A et al (2003) Kapseldurchbruche zervikaler Lymphknotenmetastasen: Diagnostischer Stellenwert der Sonographie. Ultraschall Med 24:323–330

    Article  PubMed  CAS  Google Scholar 

  91. Gritzmann N, Grasl MC et al (1990) Invasion of the carotid artery and jugular vein by lymph node metastases: detection with sonography. AJR Am J Roentgenol 154:411–414

    PubMed  CAS  Google Scholar 

  92. Yousem DM, Hatabu H et al (1995) Carotid artery invasion by head and neck masses: prediction with MR imaging. Radiology 195:715–720

    PubMed  CAS  Google Scholar 

  93. Yoo GH, Hocwald E et al (2000) Assessment of carotid artery invasion in patients with head and neck cancer. Laryngoscope 110:386–390

    Article  PubMed  CAS  Google Scholar 

  94. Zaragoza L, Sendra F et al (1993) Ultrasonography is more effective than computed tomography in excluding invasion of the carotid wall by cervical lymphadenopathies. Eur J Radiol 17:191–194

    Article  PubMed  CAS  Google Scholar 

  95. Devaney KO, Rinaldo A et al (2007) Micrometastases in cervical lymph nodes from patients with squamous carcinoma of the head and neck: should they be actively sought? Maybe. Am J Otolaryngol 28:271–274

    Article  PubMed  Google Scholar 

  96. Ng SH, Yen TC et al (2006) Prospective study of [ 18F]fluorodeoxyglucose positron emission tomography and computed tomography and magnetic resonance imaging in oral cavity squamous cell carcinoma with palpably negative neck. J Clin Oncol 24:4371–4376

    Article  PubMed  Google Scholar 

  97. Schoder H, Carlson DL et al (2006) 18F-FDG PET/CT for detecting nodal metastases in patients with oral cancer staged NO by clinical examination and CT/MRI. J Nucl Med 47:755–762

    PubMed  Google Scholar 

  98. Borgemeester MC, van den Brekel MW et al (2008) Ultrasound-guided aspiration cytology for the assessment of the clinically NO neck: factors influencing its accuracy. Head Neck 30:1505–1513

    Article  PubMed  Google Scholar 

  99. Chone CT, Magalhes RS et al (2008) Predictive value of sentinel node biopsy in head and neck cancer. Acta Otolaryngol 128:920–924

    Article  PubMed  Google Scholar 

  100. Shaha AR (2005) Advances in the management of thyroid cancer. Int J Surg 3:213–220

    Article  PubMed  Google Scholar 

  101. Gharib H, Papini E et al American Association of Clinic al Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules. Endocr Pract 1:1–43

    Google Scholar 

  102. Leenhardt L (2009) Conduite a tenir devant un nodule thyroidien. J Radiol 90:354–361

    Article  PubMed  CAS  Google Scholar 

  103. Eng CY, Quraishi MS et al Management of Thyroid nodules in adult patients. Head Neck Oncol 2:11

    Google Scholar 

  104. Hoang JK, Lee WK et al (2007) US Features of thyroid malignancy: pearls and pitfalls. Radiographics 27:847–860

    Article  PubMed  Google Scholar 

  105. Freudenberg LS, Frilling A et al (2007) Dual-modality FDG-PET/CT in follow-up of patients with recurrent iodinenegative differentiated thyroid cancer. Eur Radiol 17:3139–3147

    Article  PubMed  Google Scholar 

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Maroldi, R., Farina, D., Ravanelli, M., Botturi, E., Pittiani, F. (2011). Diagnostica per immagini: TC ed ecografia. In: Tumori della testa e del collo. Springer, Milano. https://doi.org/10.1007/978-88-470-1806-8_8

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