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The Biology of Krüppel-like Factors pp 173–184Cite as

Krüppel-like Factors in the Vascular Endothelium

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Abstract

Although Krüppel-like factors (KLFs) have been the subject of extensive biological investigation, the role of this family of transcription factors in the biology and pathophysiology of the vascular endothelium is just becoming apparent. Most investigative efforts thus far have focused on KLF2, its contribution to the endothelial vasoprotective phenotype, and its possible impact on atherogenesis. This chapter reflects on the current state of the field and highlights evolving areas where KLFs are emerging as important regulators of endothelial function.

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Author information

Authors and Affiliations

  1. Laboratory for Systems Biology, Center for Excellence in Vascular Biology, Departments of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, 02115, USA

    Guillermo García-Cardeña & Guadalupe Villarreal

  2. Harvard-MIT Division of Health, Sciences and Technology, Boston, MA, 02115, USA

    Guadalupe Villarreal

Authors
  1. Guillermo García-Cardeña
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  2. Guadalupe Villarreal
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Editor information

Editors and Affiliations

  1. Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Ryozo Nagai

  2. Division of Liver Diseases, Mount Sinai School of Medicine, 1425 Madison Avenue Room 1170C, Box 1123, New York, NY, 10029, USA

    Scott L. Friedman

  3. Research Institute, International Medical Center of Japan, 162-8655, Shinjuku-ku, Tokyo, Japan

    Masato Kasuga

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© 2009 Springer

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García-Cardeña, G., Villarreal, G. (2009). Krüppel-like Factors in the Vascular Endothelium. In: Nagai, R., Friedman, S.L., Kasuga, M. (eds) The Biology of Krüppel-like Factors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-87775-2_14

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