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Neuroprotection and Regeneration of the Spinal Cord pp 229–245Cite as

Regenerative Medicine for Spinal Cord Injury Utilizing iPS Cells

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Abstract

Reports of functional recovery from spinal cord injury (SCI) after the transplantation of rat-fetus-derived neural stem/precursor cells (NS/PCs) and murine embryonic stem cells (ES cells) have raised great expectations for the successful clinical trial of stem cell transplantation therapy. However, the ethical issues concerning about destroying human embryos or fertilized oocytes to obtain such stem cells have been a major impediment to developing clinically useful stem cell sources and to use them in clinical applications. Recently, induced pluripotent stem cells (iPS cells), which can serve as a source of autologous cell transplantation, have been attracting a lot of attention as a clinically practical alternative to stem cells obtained directly from tissues. In this chapter, we outline the neural induction of murine and human iPS cells, their therapeutic efficacy in mouse and primate SCI models, and their safety in vivo.

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Acknowledgements

 The original investigation on iPS cells was performed in collaboration with Prof. Shinya Yamanaka (Center for iPS Cell Research and Application, Kyoto University, Japan). This work was supported by grants from Grants-in-Aid for Scientific Research from JSPS and the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT); the Project for Realization of Regenerative Medicine and support for the core institutes for iPS cell research from MEXT; Research Fellowships for Young Scientists from the Japan Society for the Promotion of Science; Keio Gijuku Academic Development Funds; and by a Grant-in-Aid for the Global COE program from MEXT to Keio University.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan

    Osahiko Tsuji, Satoshi Nori, Yoshiomi Kobayashi, Kanehiro Fujiyoshi, Yoshiaki Toyama & Masaya Nakamura

  2. Department of Orthopaedic Surgery, Saitama Social Insurance Hospital, 4-9-3 Kitaurawa, Urawa, Saitama, Saitama, 330-0074, Japan

    Osahiko Tsuji

  3. Department of Orthopaedic Surgery, Tokyo Dental College Ichikawa General Hospital, 5-11-13 Sugano, Ichikawa, Chiba, 272-8513, Japan

    Satoshi Nori

  4. Department of Orthopedic Surgery, National Hospital Organization, Murayama Medical Center, 2-37-1 Gakuen, Musashimurayama, Tokyo, 208-0011, Japan

    Kanehiro Fujiyoshi

  5. Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan

    Hideyuki Okano

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  1. Osahiko Tsuji
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  2. Satoshi Nori
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  3. Yoshiomi Kobayashi
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  4. Kanehiro Fujiyoshi
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  5. Hideyuki Okano
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  6. Yoshiaki Toyama
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  7. Masaya Nakamura
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Correspondence to Masaya Nakamura .

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Editors and Affiliations

  1. Dept of Orthop & Rehabilit Med, University of Fukui Faculty of Medical Sciences, Yoshida-gun, Fukui, Japan

    Kenzo Uchida

  2. Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Tokyo, Japan

    Masaya Nakamura

  3. Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

    Hiroshi Ozawa

  4. Department of Orthopedic Surgery, Faculty of Medicine The University of Tokushima, Tokushima, Tokushima, Japan

    Shinsuke Katoh

  5. Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Tokyo, Japan

    Yoshiaki Toyama

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Tsuji, O. et al. (2014). Regenerative Medicine for Spinal Cord Injury Utilizing iPS Cells. In: Uchida, K., Nakamura, M., Ozawa, H., Katoh, S., Toyama, Y. (eds) Neuroprotection and Regeneration of the Spinal Cord. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54502-6_19

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  • DOI: https://doi.org/10.1007/978-4-431-54502-6_19

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