Abstract
Cell-surface glycans play important roles in lymphocyte traffic and homing. Cell adhesion mediated by glycans, such as selectin-mediated cell adhesion, is involved in the first step of every process of extravasation of leukocytes, either in granulocytes or in lymphocytes (Fig. 1). Glycan-mediated cell adhesion is virtually an only one cell-adhesion system that tolerates a strong shear force of normal blood flow in the general circulation. This step is crucial for every leukocyte diapedesis; without glycan-mediated cell adhesion, other secondary proteinaceous cell-adhesion molecules such as integrins or the Ig superfamily do not operate effectively. Recently, it has become increasingly clear that homing processes of various subsets of T lymphocytes are elegantly regulated by different species of cell-adhesive glycans, and alterations in glycan expression are closely associated with the pathophysiology of several well-known human diseases.
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Acknowledgments
This work was supported in part by grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology (24590364 and on innovative areas 23112520), grants-in-aid for young scientists from the Japan Society for the Promotion of Science (20790583 and 22790774), grants-in-aid for the Third-Term Comprehensive Ten-year Strategy for Cancer Control from the Ministry of Health and Welfare, and a grant from the Uehara Memorial Foundation, Japan.
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Kannagi, R., Sakuma, K., Ohmori, K. (2012). Cell-Surface Glycoconjugates Controlling Human T-Lymphocyte Homing: Implications for Bronchial Asthma and Atopic Dermatitis. In: Shibasaki, M., Iino, M., Osada, H. (eds) Chembiomolecular Science. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54038-0_16
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