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Chemokine axes in hematopoietic stem cell mobilization

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Chemokine Biology — Basic Research and Clinical Application

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Under steady state, hematopoietic cells at all stages of differentiation and some lymphoid cell populations are confined within the bone marrow, while mature cells exit and enter peripheral blood. A small population of hematopoietic stem (HSC) and progenitor (HPC) cells also traffic through the peripheral circulation. The initial observations that HPC cells are found in the blood of patients recovering from chemotherapy [1–3] led to the realization that HSC and HPC can be forced or ‘mobilized’ from marrow to blood where they can be collected by apheresis and utilized for transplantation [4].

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Authors and Affiliations

  1. Department of Microbiology & Immunology and the Walther Oncology Center, Indiana University School of Medicine and the Walther Cancer Institute, 950 West Walnut Street, Indianapolis, IN, 46202, USA

    Louis M. Pelus & Hal E. Broxmeyer

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  1. Louis M. Pelus
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  2. Hal E. Broxmeyer
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Editors and Affiliations

  1. Lilly Corporate Center, Cancer Inflammation and Cell Survival Eli Lilly and Company, Indianapolis, IN, 46285, USA

    Kuldeep Neote

  2. NitroMed, Inc., 12 Oak Park Drive, Bedford, MA, 01730, USA

    Gordon L. Letts

  3. Theodor Koch Institute, University of Bern, Freiestrasse 1, 3012, Bern, Switzerland

    Bernhard Moser

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© 2007 Birkhäuser Verlag Basel/Switzerland

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Pelus, L.M., Broxmeyer, H.E. (2007). Chemokine axes in hematopoietic stem cell mobilization. In: Neote, K., Letts, G.L., Moser, B. (eds) Chemokine Biology — Basic Research and Clinical Application. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-7437-2_10

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