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Brain Edema XV pp 111–114Cite as

Adiponectin and Traumatic Brain Injury

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Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 118))

Abstract

Adiponectin, a circulating adipose-derived hormone regulating inflammation and energy metabolism, has beneficial actions on cardiovascular disorders. Recent studies have suggested that adiponectin might be a potential molecular target for ischemic stroke therapy; however, little is known about the effects of adiponectin on traumatic brain injury. The present study examined the immunoactivity of adiponectin.

Adult male Sprague–Dawley rats were subjected to lateral fluid percussion injury using the Dragonfly device. Immuno­histochemical studies showed that the adiponectin expression was increased in the cerebral cortex at 24 h after injury and in the hippocampus at 72 h after injury. Our findings suggest that adiponectin might participate in the pathophysiological process occurring after traumatic brain injury.

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Acknowledgments

This study was supported by a research grant from The General Insurance Association of Japan.

Conflict of Interest We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Neurosurgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan

    Satoru Takeuchi, Kojiro Wada, Hiroshi Nawashiro, Yoichi Uozumi, Naoki Otani, Hideo Osada, Kimihiro Nagatani, Hiroaki Kobayashi, Takamoto Suzuki & Katsuji Shima

Authors
  1. Satoru Takeuchi
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  2. Kojiro Wada
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  3. Hiroshi Nawashiro
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  4. Yoichi Uozumi
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  5. Naoki Otani
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  6. Hideo Osada
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  7. Kimihiro Nagatani
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  8. Hiroaki Kobayashi
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  9. Takamoto Suzuki
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  10. Katsuji Shima
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Corresponding author

Correspondence to Satoru Takeuchi .

Editor information

Editors and Affiliations

  1. School of Medicine, Dept. Neurological Surgery, Nihon University, Oyaguchikami-machi 30-1, Tokyo, 173-8610, Japan

    Yoichi Katayama

  2. School of Medicine, Departments of Neurological Surgery and, Nihon University, 30-1 Oyaguchi Kamimachi, Itabashi-ku, Tokyo, 173-8610, Japan

    Takeshi Maeda

  3. , Department of Clinical Laboratory, Namegata District General Hospital, 98-8 Inouefujii, Namegata 98-8, Ibaraki, 311-3516, Japan

    Toshihiko Kuroiwa

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© 2013 Springer-Verlag Wien

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Cite this paper

Takeuchi, S. et al. (2013). Adiponectin and Traumatic Brain Injury. In: Katayama, Y., Maeda, T., Kuroiwa, T. (eds) Brain Edema XV. Acta Neurochirurgica Supplement, vol 118. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1434-6_19

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  • DOI: https://doi.org/10.1007/978-3-7091-1434-6_19

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-1433-9

  • Online ISBN: 978-3-7091-1434-6

  • eBook Packages: MedicineMedicine (R0)

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