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Magnesium Sulphate for Aneurysmal Subarachnoid Hemorrhage: Why, How, and Current Controversy

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Cerebral Vasospasm: Neurovascular Events After Subarachnoid Hemorrhage

Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 115))

Abstract

The neuroprotective effect of magnesium sulphate infusion has been confirmed in experimental models. Pilot clinical trials using magnesium sulphate in patients with acute aneurysmal subarachnoid hemorrhage (SAH) have reported a trend toward a reduction in clinical deterioration due to delayed cerebral ischemia (DCI) and an improvement in clinical outcomes. However, our recent multicenter trials and systemic review failed to confirm benefit in neurological outcome. In post hoc analysis, data also did not support that a higher dose of magnesium sulphate infusion might improve clinical outcome. We here review the current literature, highlight these discrepancies, and explore alternatives.

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Acknowledgements

None.

Sources of Funding

IMASH was supported by the Hong Kong Research Grant Council. The funding source had no role in the study design, collection, analysis or interpretation of data, manuscript preparation or decision for submission.

Disclosure

None.

Conflicts of Interest

We declare that we have no conflict of interest.

Author information

Authors and Affiliations

  1. Division of Neurosurgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China

    George Kwok Chu Wong M.D. & Wai Sang Poon FRCS

  2. Department of Surgery, Prince of Wales Hospital, 4/F Clinical Science Building, 1 Ngan Shing Street, Shatin, Hong Kong SAR, China

    George Kwok Chu Wong M.D.

Authors
  1. George Kwok Chu Wong M.D.
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  2. Wai Sang Poon FRCS
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Corresponding author

Correspondence to George Kwok Chu Wong M.D. .

Editor information

Editors and Affiliations

  1. , Department of Neurosurgery, University of Cincinnati, Stetson, Suite 2200 260, Cincinnati, 45267-0515, Ohio, USA

    Mario Zuccarello

  2. College of Medicine, Department of Neurology, University of Cincinnati, Albert Sabin Way 231MSB room 1, Cincinnati, 46267-0536, Ohio, USA

    Joseph F. Clark

  3. College of Medicine, Dept. of Neurology and Neurosurgery, University of Cincinnati, Albert Sabin Way 231ML0517, Cincinnati, 45267-0517, Ohio, USA

    Gail Pyne-Geithman

  4. College of Medicine, Dept. of Neurosurgery, University of Cincinnati, Stetson St. Suite 260ML0515, Cincinnati, 45219, Ohio, USA

    Norberto Andaluz

  5. College of Medicine, Dept. of Neurosurgery, University of Cincinnati, Stetson, Suite 2200 260, Cincinnati, 45219, Ohio, USA

    Jed A. Hartings

  6. , Dept. of Emergency Medicine, University of Cincinnati, Albert Sabin Way 231ML0769, Cincinnati, 45267-0769, Ohio, USA

    Opeolu M. Adeoye

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Wong, G.K.C., Poon, W.S. (2013). Magnesium Sulphate for Aneurysmal Subarachnoid Hemorrhage: Why, How, and Current Controversy. In: Zuccarello, M., Clark, J., Pyne-Geithman, G., Andaluz, N., Hartings, J., Adeoye, O. (eds) Cerebral Vasospasm: Neurovascular Events After Subarachnoid Hemorrhage. Acta Neurochirurgica Supplement, vol 115. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1192-5_10

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  • DOI: https://doi.org/10.1007/978-3-7091-1192-5_10

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-1191-8

  • Online ISBN: 978-3-7091-1192-5

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