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Early Detection of Epileptic Seizures in Pigs Based on Vagus Nerve Activity

  • Conference paper
Converging Clinical and Engineering Research on Neurorehabilitation

Part of the book series: Biosystems & Biorobotics ((BIOSYSROB,volume 1))

Abstract

Vagus nerve stimulation is currently used as a treatment of otherwise intractable epilepsy. The efficacy of the treatment does, however, remain modest, but could potentially be improved by on-demand stimulation. A method for early seizure detection in rats based on vagus nerve activity was described previously. Such methods could enable closed loop on-demand stimulation. In this study, we tested the method in three pigs. Early prediction of seizures, i.e. prior to the onset of tonic-clonic seizures, was possible in all animals, whereas administration of adrenaline did not provoke false detections.

This study was supported by the Danish Agency for Science Technology and Innovation, Ministry of Science, Innovation and Higher Education.

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Authors and Affiliations

  1. Center for Sensory-Motor Interaction, Department of Health Science and Technology, Aalborg University, DK-9220, Aalborg, Denmark

    Thomas N. Nielsen, Kristian R. Harreby & Cristian Sevcencu

  2. Medical Informatics Group, Department of Health Science and Technology, Aalborg University, DK-9220, Aalborg, Denmark

    Johannes J. Struijk

Authors
  1. Thomas N. Nielsen
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  2. Johannes J. Struijk
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  3. Kristian R. Harreby
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  4. Cristian Sevcencu
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Corresponding author

Correspondence to Thomas N. Nielsen .

Editor information

Editors and Affiliations

  1. Bioengineering Group, Spanish National Research Council (CSIC), Madrid, Spain

    José L Pons

  2. Bioengineering Group, Spanish National Research Council (CSIC), Madrid, Spain

    Diego Torricelli

  3. Bioengineering Group, Spanish National Research Council (CSIC), Madrid, Spain

    Marta Pajaro

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© 2013 Springer-Verlag Berlin Heidelberg

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Nielsen, T.N., Struijk, J.J., Harreby, K.R., Sevcencu, C. (2013). Early Detection of Epileptic Seizures in Pigs Based on Vagus Nerve Activity. In: Pons, J., Torricelli, D., Pajaro, M. (eds) Converging Clinical and Engineering Research on Neurorehabilitation. Biosystems & Biorobotics, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-34546-3_7

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  • DOI: https://doi.org/10.1007/978-3-642-34546-3_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-34545-6

  • Online ISBN: 978-3-642-34546-3

  • eBook Packages: EngineeringEngineering (R0)

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