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(+)-11,11′-Dideoxyverticillin A

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Total Synthesis of Natural Products

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Abstract

The dimeric epipolythiodiketopiperazine alkaloids are a family of fungal metabolites renowned for their structural and functional complexity [1]. Isolated across eight genera of fungi, over 40 members of this class of natural products have been discovered since the isolation of their inaugural members, (+)-chaetocin A (2) [2] and (+)-verticillin A [3], in 1970 (Fig. 9.1). As evidenced by the large number of constituents comprising this family, there are many avenues by which each member derives its identity.

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Notes

  1. 1.

    We acknowledge financial support by NIH-NIGMS (GM089732).

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Authors and Affiliations

  1. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA

    Justin Kim & Mohammad Movassaghi

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  1. Justin Kim
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  2. Mohammad Movassaghi
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Correspondence to Mohammad Movassaghi .

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  1. Firestone Court 3, Skillman, 08558, New Jersey, USA

    Jie Jack Li

  2. , Dept. of Chemistry and Chemical Biology, Harvard University, Oxford Street 12, Cambridge, 02138, USA

    E.J. Corey

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Kim, J., Movassaghi, M. (2012). (+)-11,11′-Dideoxyverticillin A. In: Li, J., Corey, E. (eds) Total Synthesis of Natural Products. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-34065-9_9

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