Skip to main content
SpringerLink
Log in

Liver Transplantation for Hepatocellular Carcinoma

  • Chapter
Primary Liver Cancer

  • 1260 Accesses

Abstract

Starzl performed the world’s first liver transplantation (LT) for hepatocellular carcinoma (HCC) in the United States in 1963. In the world’s first 7 LTs, 3 of them were performed for HCC patients. By now, the history course of LT for HCC has gone through half a century. During these years, it has experienced the initial attempt, depression and today’s steady development.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ringe B, Pichlmayr R, Wittekind C, et al. Surgical treatment of hepatocellular carcinoma: experience with liver resection and transplantation in 198 patients. World J Surg, 1991, 15: 270–285.

    Article  PubMed  CAS  Google Scholar 

  2. Van Thiel D H, Carr B, Iwatsuki S, et al. The 11-year Pittsburgh experience with liver transplantation for hepatocellular carcinoma: 1981–1991. J Surg Oncol Suppl, 1993, 3: 78–82.

    Article  PubMed  Google Scholar 

  3. Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med, 1996, 334: 693–699.

    Article  PubMed  CAS  Google Scholar 

  4. Marsh J W, Dvorchik I, Bonham C A, et al. Is the pathologic TNM staging system for patients with hepatoma predictive of outcome? Cancer, 2000, 88: 538–543.

    Article  PubMed  CAS  Google Scholar 

  5. Chen J, Xu X, Ling Q, et al. Role of Pittsburgh modified TNM criteria in prognosis prediction of liver transplantation for hepatocellular carcinoma. Chin Med J (Engl), 2007, 120: 2200–2203.

    Google Scholar 

  6. Yao F Y, Ferrell L, Bass N M, et al. Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival. Hepatology, 2001, 33: 1394–1403.

    Article  PubMed  CAS  Google Scholar 

  7. Duffy J P, Vardanian A, Benjamin E, et al. Liver transplantation criteria for hepatocellular carcinoma should be expanded: a 22-year experience with 467 patients at UCLA. Ann Surg, 2007, 246: 502–509, 509–511.

    Article  PubMed  Google Scholar 

  8. Moray G, Karakayali F, Yilmaz U, et al. Expanded criteria for hepatocellular carcinoma and liver transplantation. Transplant Proc, 2007, 39: 1171–1174.

    Article  PubMed  CAS  Google Scholar 

  9. Jonas S, Mittler J, Pascher A, et al. Living donor liver transplantation of the right lobe for hepatocellular carcinoma in cirrhosis in a European center. Liver Transpl, 2007, 13: 896–903.

    Article  PubMed  Google Scholar 

  10. Sugawara Y, Tamura S, Makuuchi M. Living donor liver transplantation for hepatocellular carcinoma: Tokyo University series. Dig Dis, 2007, 25: 310–312.

    Article  PubMed  Google Scholar 

  11. Ito T, Takada Y, Ueda M, et al. Expansion of selection criteria for patients with hepatocellular carcinoma in living donor liver transplantation. Liver Transpl, 2007, 13: 1637–1644.

    Article  PubMed  Google Scholar 

  12. Lee S G, Hwang S, Moon D B, et al. Expanded indication criteria of living donor liver transplantation for hepatocellular carcinoma at one large-volume center. Liver Transpl, 2008, 14: 935–945.

    Article  PubMed  Google Scholar 

  13. Pawlik T M, Delman K A, Vauthey J N, et al. Tumor size predicts vascular invasion and histologic grade: implications for selection of surgical treatment for hepatocellular carcinoma. Liver Transpl, 2005, 11: 1086–1092.

    Article  PubMed  Google Scholar 

  14. Mak K S, Tan K C. Liver transplantation for hepatocellular carcinoma: an Asian perspective. Asian J Surg, 2002, 25: 271–276.

    Article  PubMed  Google Scholar 

  15. Xu X, Zheng S S, Liang T B, et al. Orthotopic liver transplantation for patients with hepatocellular carcinoma complicated by portal vein tumor thrombi. Hepatobiliary Pancreat Dis Int, 2004, 3: 341–344.

    PubMed  Google Scholar 

  16. Zheng S S, Xu X, Wu J, et al. Liver transplantation for hepatocellular carcinoma: Hangzhou experiences. Transplantation, 2008, 85: 1726–1732.

    Article  PubMed  CAS  Google Scholar 

  17. Fan S T. Selection of HCC patients for liver transplantation: the Milan criteria, Hangzhou criteria and beyond. Hepatobiliary Pancreat Dis Int, 2008, 7: 233–234.

    PubMed  Google Scholar 

  18. Busuttil R W. Liver transplantation for hepatocellular carcinoma: the Hangzhou experience. Hepatobiliary Pancreat Dis Int, 2008, 7: 235–236.

    PubMed  Google Scholar 

  19. Sato Y, Yamamoto S, Oya H, et al. Preoperative human-telomerase reverse transcriptase mRNA in peripheral blood and tumor recurrence in living-related liver transplantation for hepatocellular carcinoma. Hepatogastroenterology, 2005, 52: 1325–1328.

    PubMed  Google Scholar 

  20. Marsh J W, Finkelstein S D, Demetris A J, et al. Genotyping of hepatocellular carcinoma in liver transplant recipients adds predictive power for determining recurrence-free survival. Liver Transpl, 2003, 9: 664–671.

    Article  PubMed  Google Scholar 

  21. Majno P, Giostra E, Morel P, et al. Management of hepatocellular carcinoma in the waiting list before liver transplantation. J Hepatol, 2005, 42: S134–S143.

    Article  PubMed  Google Scholar 

  22. Lencioni R, Crocetti L, Della Pina M C, et al. Guidelines for imaging focal lesions in liver cirrhosis. Expert Rev Gastroenterol Hepatol, 2008, 2: 697–703.

    Article  PubMed  Google Scholar 

  23. Kamel I R, Liapi E, Fishman E K. Multidetector CT of hepatocellular carcinoma. Best Pract Res Clin Gastroenterol, 2005, 19: 63–89.

    Article  PubMed  Google Scholar 

  24. Willatt J M, Hussain H K, Adusumilli S, et al. MR Imaging of hepatocellular carcinoma in the cirrhotic liver: challenges and controversies. Radiology, 2008, 247: 311–330.

    Article  PubMed  Google Scholar 

  25. Seale M K, Catalano O A, Saini S, et al. Hepatobiliary-specific MR contrast agents: role in imaging the liver and biliary tree. Radiographics, 2009, 29: 1725–1748.

    Article  PubMed  Google Scholar 

  26. Katyal S, Oliver J H, Peterson M S, et al. Extrahepatic metastases of hepatocellular carcinoma. Radiology 2000, 216: 698–703.

    PubMed  CAS  Google Scholar 

  27. Harvey C J, Albrecht T. Ultrasound of focal liver lesions. Eur Radiol, 2001, 11: 1578–1593.

    Article  PubMed  CAS  Google Scholar 

  28. Sugiyama M, Sakahara H, Torizuka T, et al. 18F-FDG PET in the detection of extrahepatic metastases from hepatocellular carcinoma. J Gastroenterol, 2004, 39: 961–968.

    Article  PubMed  CAS  Google Scholar 

  29. Lee J W, Paeng J C, Kang K W, et al. Prediction of tumor recurrence by 18F-FDG PET in liver transplantation for hepatocellular carcinoma. J Nucl Med, 2009, 50: 682–687.

    Article  PubMed  Google Scholar 

  30. Yuen M F, Lai C L. Serological markers of liver cancer. Best Pract Res Clin Gastroenterol, 2005, 19: 91–99.

    Article  PubMed  CAS  Google Scholar 

  31. Fujiyama S, Tanaka M, Maeda S, et al. Tumor markers in early diagnosis, follow-up and management of patients with hepatocellular carcinoma. Oncology, 2002, 62 Suppl 1: 57–63.

    Article  PubMed  CAS  Google Scholar 

  32. Toyoda H, Kumada T, Kiriyama S, et al. Prognostic significance of simultaneous measurement of three tumor markers in patients with hepatocellular carcinoma. Clin Gastroenterol Hepatol, 2006, 4: 111–117.

    Article  PubMed  CAS  Google Scholar 

  33. Lao O B, Weissman J, Perkins J D. Pre-transplant therapy for hepatocellular carcinoma is associated with a lower recurrence after liver transplantation. Clin Transplant, 2009, 23: 874–881.

    Article  PubMed  Google Scholar 

  34. Yao F Y, Bass N M, Nikolai B, et al. Liver transplantation for hepatocellular carcinoma: analysis of survival according to the intention-to-treat principle and dropout from the waiting list. Liver Transpl, 2002, 8: 873–883.

    Article  PubMed  Google Scholar 

  35. Ng K K, Lo C M, Liu C L, et al. Survival analysis of patients with transplantable recurrent hepatocellular carcinoma: implications for salvage liver transplant. Arch Surg, 2008, 143: 68–74.

    Article  PubMed  Google Scholar 

  36. Belghiti J. Resection and liver transplantation for HCC. J Gastroenterol, 2009, 44 Suppl 19: 132–135.

    Article  PubMed  Google Scholar 

  37. Llovet J M, Mas X, Aponte J J, et al. Cost effectiveness of adjuvant therapy for hepatocellular carcinoma during the waiting list for liver transplantation. Gut, 2002, 50: 123–128.

    Article  PubMed  CAS  Google Scholar 

  38. Cha C, Fong Y, Jarnagin W R, et al. Predictors and patterns of recurrence after resection of hepatocellular carcinoma. J Am Coll Surg, 2003, 197: 753–758.

    Article  PubMed  Google Scholar 

  39. Liapi E, Geschwind J F. Transcatheter and ablative therapeutic approaches for solid malignancies. J Clin Oncol, 2007, 25: 978–986.

    Article  PubMed  Google Scholar 

  40. Shiina S. Japanese experience in ablation therapies for hepatocellular carcinoma. Hepatol Res, 2007, 37 (Suppl 2): S223–S229.

    Article  PubMed  Google Scholar 

  41. Zhou W P, Lai E C, Li A J, et al. Prospective, randomized, controlled trial of preoperative transarterial chemoembolization for resectable large hepatocellular carcinoma. Ann Surg, 2009, 249: 195–202.

    Article  PubMed  Google Scholar 

  42. Graziadei I W, Sandmueller H, Waldenberger P, et al. Chemoembolization followed by liver transplantation for hepatocellular carcinoma impedes tumor progression while on the waiting list and leads to excellent outcome. Liver Transpl, 2003, 9: 557–563.

    Article  PubMed  Google Scholar 

  43. Lo C M, Fan S T, Liu C L, et al. The role and limitation of living donor liver transplantation for hepatocellular carcinoma. Liver Transpl, 2004, 10: 440–447.

    Article  PubMed  Google Scholar 

  44. Vakili K, Pomposelli J J, Cheah Y L, et al. Living donor liver transplantation for hepatocellular carcinoma: increased recurrence but improved survival. Liver Transpl, 2009, 15: 1861–1866.

    Article  PubMed  Google Scholar 

  45. Fouzas I, Sotiropoulos G C, Lang H, et al. Living donor liver transplantation for hepatocellular carcinoma in patients exceeding the UCSF Criteria. Transplant Proc, 2008, 40: 3185–3188.

    Article  PubMed  CAS  Google Scholar 

  46. Fujiki M, Takada Y, Ogura Y, et al. Significance of des-gamma-carboxy prothrombin in selection criteria for living donor liver.transplantation for hepatocellular carcinoma. Am J Transplant, 2009, 9: 2362–2371.

    Article  PubMed  CAS  Google Scholar 

  47. Di Sandro S, Slim A O, Giacomoni A, et al. Living donor liver transplantation for hepatocellular carcinoma: long-term results compared with deceased donor liver transplantation. Transplant Proc, 2009, 41: 1283–1285.

    Article  PubMed  Google Scholar 

  48. Lo C M, Fan S T, Liu C L, et al. Living donor versus deceased donor liver transplantation for early irresectable hepatocellular carcinoma. Br J Surg, 2007, 94: 78–86.

    Article  PubMed  CAS  Google Scholar 

  49. Fisher R A, Kulik L M, Freise C E, et al., and the A2ALL Study Group. Hepatocellular carcinoma recurrence and death following living and deceased donor liver transplantation. Am J Transplant, 2007, 7: 1601–1608.

    Article  PubMed  CAS  Google Scholar 

  50. Takada Y, Ueda M, Ito T, et al. Living donor liver transplantation as a secondline secondline therapeutic strategy for patients with hepatocellular carcinoma. Liver Transpl, 2006, 12: 912–919.

    Article  PubMed  Google Scholar 

  51. Kulik L, Abecassis M. Living donor liver transplantation for hepatocellular carcinoma. Gastroenterology, 2004, 127(5 Suppl 1): 277–282.

    Article  Google Scholar 

  52. Marcos A, Fisher R A, Ham J M, et al. Liver regeneration and function in donor and recipient after right lobe adult to adult living donor liver transplantation. Transplantation, 2000, 69: 1375–1379.

    Article  PubMed  CAS  Google Scholar 

  53. Drixler T A, Vogten M J, Ritchie E D, et al. Liver regeneration is an angiogenesis-associated phenomenon. Ann Surg, 2002, 236: 703–711.

    Article  PubMed  Google Scholar 

  54. Raia S, Nery J R, Mies S. Liver transplantation from live donors. Lancet, 1989, 2: 497.

    Article  PubMed  CAS  Google Scholar 

  55. Barr M L, Belghiti J, Villamil F G, et al. A report of the Vancouver Forum on the care of the live organ donor: lung, liver, pancreas, and intestine data and medical guidelines. Transplantation, 2006, 81: 1373–1385.

    Article  PubMed  Google Scholar 

  56. Ringe B, Strong R W. The dilemma of living liver donor death: to report or not to report? Transplantation, 2008, 85: 790–793.

    Article  PubMed  Google Scholar 

  57. Human Organ Transplant Ordinance. The State Council of P. R. China. Implemented from June 1st, 2007.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Hepatobiliary&Pancreatic Surgery and Liver Transplantation Center, Department of Surgery, First Affiliated Hospital, Zhejiang University College of Medicine, 79 Qing Chun Road, Hangzhou, 310003, China

    Shusen Zheng

Authors
  1. Shusen Zheng
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Zhejiang University Press, Hangzhou and Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Zheng, S. (2012). Liver Transplantation for Hepatocellular Carcinoma. In: Primary Liver Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28702-2_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-28702-2_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-28701-5

  • Online ISBN: 978-3-642-28702-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation